List of works - John Moult

A decade of CASP: progress, bottlenecks and prognosis in protein structure prediction.

scientific article

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

scientific article published on 23 October 2009

A unifold, mesofold, and superfold model of protein fold use

article

Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants

scientific article published on 03 September 2019

Assessment of patient clinical descriptions and pathogenic variants from gene panel sequences in the CAGI-5 intellectual disability challenge

scientific article published on 03 July 2019

Assessment of predicted enzymatic activity of α-N-acetylglucosaminidase variants of unknown significance for CAGI 2016

scientific article published on 01 September 2019

Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics.

scientific article

CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases

scientific article published on 03 September 2019

CAGI4 Crohn's exome challenge: Marker SNP versus exome variant models for assigning risk of Crohn disease

scientific article published on 16 May 2017

CAGI4 SickKids clinical genomes challenge: A pipeline for identifying pathogenic variants

scientific article published on 16 May 2017

CAPRI: a Critical Assessment of PRedicted Interactions

scientific article (publication date: July 2003)

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10

scientific article

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

scientific article published on June 2009

Comparative Modeling in Structural Genomics

article

Critical assessment of methods of protein structure prediction (CASP)--round 6.

scientific article

Critical assessment of methods of protein structure prediction (CASP)--round x

scientific article (publication date: February 2014)

Critical assessment of methods of protein structure prediction (CASP)-Round XII.

scientific article published on 30 October 2017

Critical assessment of methods of protein structure prediction (CASP)-Round XIII

scientific article published on 23 October 2019

Critical assessment of methods of protein structure prediction (CASP)-round V.

scientific article

Critical assessment of methods of protein structure prediction-Round VII

scientific article

Detection of operons.

scientific article

Determination of disease phenotypes and pathogenic variants from exome sequence data in the CAGI 4 gene panel challenge

scientific article

Ensemble variant interpretation methods to predict enzyme activity and assign pathogenicity in the CAGI4 NAGLU (Human N-acetyl-glucosaminidase) and UBE2I (Human SUMO-ligase) challenges.

scientific article published on 24 May 2017

Evaluation of disorder predictions in CASP5

article

Evaluation of the template-based modeling in CASP12.

scientific article

Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics

scientific article published on 23 May 2008

Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies

scientific article

Harnessing formal concepts of biological mechanism to analyze human disease

scientific article published on 26 December 2018

Identification and analysis of deleterious human SNPs.

scientific article

Lessons from the CAGI-4 Hopkins clinical panel challenge

scientific article published on 11 April 2017

Matching whole genomes to rare genetic disorders: Identification of potential causative variants using phenotype-weighted knowledge in the CAGI SickKids5 clinical genomes challenge

scientific article published on 03 November 2019

Modeling SARS-CoV-2 proteins in the CASP-commons experiment

Molecular modeling of protein function regions.

scientific article

Neighbor Overlap Is Enriched in the Yeast Interaction Network: Analysis and Implications ⬇️

scientific article published on June 26, 2012

Outcome of a workshop on applications of protein models in biomedical research

scientific article (publication date: 13 February 2009)

Outcome of a workshop on archiving structural models of biological macromolecules

scientific article

Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI-5

scientific article published on 17 August 2019

Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges

scientific article published on 24 June 2019

Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution

scientific article

Protein family clustering for structural genomics.

scientific article published on 9 September 2005

Protein stability and in vivo concentration of missense mutations in phenylalanine hydroxylase.

scientific article

Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules

scientific article

Reports from CAGI: The Critical Assessment of Genome Interpretation.

scientific article published in September 2017

Reports from the fifth edition of CAGI: The Critical Assessment of Genome Interpretation

scientific article published on 26 August 2019

SNPs3D: candidate gene and SNP selection for association studies.

scientific article

Stochastic noise in splicing machinery

scientific article published on 22 June 2009

Structural Basis for the Mechanism and Substrate Specificity of Glycocyamine Kinase, a Phosphagen Kinase Family Member ,

scientific article

Structural and functional impact of cancer-related missense somatic mutations

scientific article

Structural implication of splicing stochastics

scientific article published on 15 June 2009

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).

scientific article published on 28 September 2017

Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction

scientific article

The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses

scientific article

The significance of performance ranking in CASP--response to Marti-Renom et al.

scientific article

Three-dimensional structural location and molecular functional effects of missense SNPs in the T cell receptor V? domain

article

Towards computing with proteins.

scientific article

Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges.

scientific article published on 21 June 2017

List of works by John Moult

A decade of CASP: progress, bottlenecks and prognosis in protein structure prediction.

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

A unifold, mesofold, and superfold model of protein fold use

Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants

Assessment of patient clinical descriptions and pathogenic variants from gene panel sequences in the CAGI-5 intellectual disability challenge

Assessment of predicted enzymatic activity of α-N-acetylglucosaminidase variants of unknown significance for CAGI 2016

Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics.

CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases

CAGI4 Crohn's exome challenge: Marker SNP versus exome variant models for assigning risk of Crohn disease

CAGI4 SickKids clinical genomes challenge: A pipeline for identifying pathogenic variants

CAPRI: a Critical Assessment of PRedicted Interactions

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

Comparative Modeling in Structural Genomics

Critical assessment of methods of protein structure prediction (CASP)--round 6.

Critical assessment of methods of protein structure prediction (CASP)--round x

Critical assessment of methods of protein structure prediction (CASP)-Round XII.

Critical assessment of methods of protein structure prediction (CASP)-Round XIII

Critical assessment of methods of protein structure prediction (CASP)-round V.

Critical assessment of methods of protein structure prediction-Round VII

Detection of operons.

Determination of disease phenotypes and pathogenic variants from exome sequence data in the CAGI 4 gene panel challenge

Ensemble variant interpretation methods to predict enzyme activity and assign pathogenicity in the CAGI4 NAGLU (Human N-acetyl-glucosaminidase) and UBE2I (Human SUMO-ligase) challenges.

Evaluation of disorder predictions in CASP5

Evaluation of the template-based modeling in CASP12.

Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics

Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies

Harnessing formal concepts of biological mechanism to analyze human disease

Harnessing formal concepts of biological mechanism to analyze human disease

Identification and analysis of deleterious human SNPs.

Lessons from the CAGI-4 Hopkins clinical panel challenge

Matching whole genomes to rare genetic disorders: Identification of potential causative variants using phenotype-weighted knowledge in the CAGI SickKids5 clinical genomes challenge

Modeling SARS-CoV-2 proteins in the CASP-commons experiment

Molecular modeling of protein function regions.

Neighbor Overlap Is Enriched in the Yeast Interaction Network: Analysis and Implications ⬇️

Outcome of a workshop on applications of protein models in biomedical research

Outcome of a workshop on archiving structural models of biological macromolecules

Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI-5

Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges

Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution

Protein family clustering for structural genomics.

Protein stability and in vivo concentration of missense mutations in phenylalanine hydroxylase.

Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules

Reports from CAGI: The Critical Assessment of Genome Interpretation.

Reports from the fifth edition of CAGI: The Critical Assessment of Genome Interpretation

SNPs3D: candidate gene and SNP selection for association studies.

Stochastic noise in splicing machinery

Structural Basis for the Mechanism and Substrate Specificity of Glycocyamine Kinase, a Phosphagen Kinase Family Member ,

Structural and functional impact of cancer-related missense somatic mutations

Structural implication of splicing stochastics

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).

Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction

The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses

The significance of performance ranking in CASP--response to Marti-Renom et al.

Three-dimensional structural location and molecular functional effects of missense SNPs in the T cell receptor V? domain

Towards computing with proteins.

Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges.