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List of works by Ron Heeren

'On the Spot' Digital Pathology of Breast Cancer Based on Single-Cell Mass Spectrometry Imaging

scientific article published on 12 April 2022

A MASSive laboratory tour. An interactive mass spectrometry outreach activity for children.

scientific article published on 17 May 2013

A concise review of mass spectrometry imaging.

scientific article

A critical evaluation of the current state-of-the-art in quantitative imaging mass spectrometry.

scientific article

A database application for pre-processing, storage and comparison of mass spectra derived from patients and controls.

scientific article published on 5 September 2006

A multimodal mass spectrometry imaging approach for the study of musculoskeletal tissues

article published in 2012

A new imaging method for understanding chemical dynamics: efficient slice imaging using an in-vacuum pixel detector.

scientific article

A novel workflow control system for Fourier transform ion cyclotron resonance mass spectrometry allows for unique on-the-fly data-dependent decisions.

scientific article

A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry

scientific article published on 27 February 2019

A review of complementary separation methods and matrix assisted laser desorption ionization-mass spectrometry imaging: lowering sample complexity

scientific article

Absorption mode FTICR mass spectrometry imaging

scientific article

Active learning for convenient annotation and classification of secondary ion mass spectrometry images.

scientific article published on 13 December 2012

Advanced Mass Calibration and Visualization for FT-ICR Mass Spectrometry Imaging ⬇️

scientific article published on August 28, 2012

An alternative paper based tissue washing method for mass spectrometry imaging: localized washing and fragile tissue analysis

scientific article

An external matrix-assisted laser desorption ionization source for flexible FT-ICR Mass spectrometry imaging with internal calibration on adjacent samples.

scientific article

An in-vacuum, pixelated detection system for mass spectrometric analysis and imaging of macromolecules

Atheroma-Specific Lipids in ldlr-/- and apoe-/- Mice Using 2D and 3D Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

scientific article published on 12 August 2020

Atypical behavior in the electron capture induced dissociation of biologically relevant transition metal ion complexes of the peptide hormone oxytocin

Automated, feature-based image alignment for high-resolution imaging mass spectrometry of large biological samples.

scientific article published on 18 March 2008

Automated, parallel mass spectrometry imaging and structural identification of lipids

scientific article published on 21 May 2018

Automatic generic registration of mass spectrometry imaging data to histology using nonlinear stochastic embedding

scientific article

C60 secondary ion Fourier transform ion cyclotron resonance mass spectrometry

scientific article published on 18 November 2011

C60+ secondary ion microscopy using a delay line detector.

scientific article

Cellular resolution in clinical MALDI mass spectrometry imaging: the latest advancements and current challenges

scientific article published on 30 October 2019

Characterization of lipidic markers of chondrogenic differentiation using mass spectrometry imaging

scientific article

Characterization of phosphatidylcholine oxidation products by MALDI MS(n).

scientific article

Clinical use of mass spectrometry (imaging) for hard tissue analysis in abnormal fracture healing

scientific article published on 12 February 2020

Cluster secondary ion mass spectrometry microscope mode mass spectrometry imaging.

scientific article

Combined MR, fluorescence and histology imaging strategy in a human breast tumor xenograft model ⬇️

scientific article published on September 4, 2012

Combined Quantitative (Phospho)proteomics and Mass Spectrometry Imaging Reveal Temporal and Spatial Protein Changes in Human Intestinal Ischemia-Reperfusion

scientific article published on 07 December 2021

Combined infrared multiphoton dissociation and electron-capture dissociation using co-linear and overlapping beams in Fourier transform ion cyclotron resonance mass spectrometry

scientific article published on 01 January 2006

Combining Time-of-Flight Secondary Ion Mass Spectrometry Imaging Mass Spectrometry and CARS Microspectroscopy Reveals Lipid Patterns Reminiscent of Gene Expression Patterns in the Wing Imaginal Disc of Drosophila melanogaster.

scientific article

Comparative gas-phase activation of two similar non-covalent heptameric protein complexes: gp31 and GroES

article

Corrigendum to "Software tools of the Computis European project to process mass spectrometry images an experimental and theoretical study" [Eur. J. Mass Spectrom. 20(5), 351-360 (2014)]

scientific article published on 01 January 2014

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

article

Deciphering Metabolic Heterogeneity by Single-Cell Analysis

scientific article published on 08 October 2019

Design and Performance of a Novel Interface for Combined Matrix-Assisted Laser Desorption Ionization at Elevated Pressure and Electrospray Ionization with Orbitrap Mass Spectrometry.

scientific article

Detailed molecular characterization of castor oil ethoxylates by liquid chromatography multistage mass spectrometry

scientific article published on 17 August 2011

Detection systems for mass spectrometry imaging: A perspective on novel developments with a focus on active pixel detectors ⬇️

scientific article published on January 15, 2013

Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis

article

Digestion-Free Analysis of Peptides from 30-year-old Formalin-Fixed, Paraffin-Embedded Tissue by Mass Spectrometry Imaging

scientific article published on 18 July 2018

Direct ion imaging approach for investigation of ion dynamics in multipole ion guides.

scientific article

Direct molecular imaging of Lymnaea stagnalis nervous tissue at subcellular spatial resolution by mass spectrometry.

scientific article

Discrimination between charge-catalyzed and charge-independent fragmentation processes of cationized poly(n-butyl acrylate)

scientific article published on 01 November 2010

Discrimination of Polymers by Using Their Characteristic Collision Energy in Tandem Mass Spectrometry

scientific article published on 20 October 2010

Discussion point: reporting guidelines for mass spectrometry imaging

scientific article published on 01 March 2015

Dissociation and vibrational excitation of H2 molecules and wall influence on the densities in a multicusp ion source

scientific article published on 01 October 1989

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

scientific article published in Scientific Reports

Distributed computing strategies for processing of FT-ICR MS imaging datasets for continuous mode data visualization.

scientific article

Disulfide bond cleavages observed in SORI-CID of three nonapeptides complexed with divalent transition-metal cations.

scientific article published in April 2007

Does double electron capture lead to the formation of biradicals? An ECD-SORI-CID study on lacticin 481.

scientific article published in October 2005

Dynamics of Molecules Observed at Crude-Oil-Gas Interfaces by Time-of-Flight Secondary Ion Mass Spectrometry Imaging

scientific article published on 09 October 2020

Effect of local matrix crystal variations in matrix-assisted ionization techniques for mass spectrometry.

scientific article

Electron Capture Dissociation as Structural Probe for Noncovalent Gas-Phase Protein Assemblies

scientific article published on 01 October 2006

Electron capture and collisionally activated dissociation mass spectrometry of doubly charged hyperbranched polyesteramides

scientific article published on 01 April 2003

Electron capture dissociation at low temperatures reveals selective dissociations

scientific article published on 01 December 2004

Electron capture dissociation of peptide hormone changes upon opening of the tocin ring and complexation with transition metal cations.

scientific article published in January 2009

Electrospray ionization tandem mass spectrometry of ammonium cationized polyethers

scientific article published on 05 March 2011

Endgroup determination of synthetic polymers by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

scientific article

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

scientific article published on 09 August 2019

Enhanced capabilities for imaging gangliosides in murine brain with matrix-assisted laser desorption/ionization and desorption electrospray ionization mass spectrometry coupled to ion mobility separation

scientific article

Enhanced detection of high-mass proteins by using an active pixel detector.

scientific article

Escherichia coli minicell membranes are enriched in cardiolipin.

scientific article published on October 2001

Evaluating the VLAM-G toolkit on the DAS-2

Evaluation of Thin-Layer Chromatography-Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Imaging for Visualization of Crude Oil Interactions

scientific article published on 07 June 2018

Examples of Fourier transform ion cyclotron resonance mass spectrometry developments: from ion physics to remote access biochemical mass spectrometry.

scientific article published in January 2005

Experimental and Data Analysis Considerations for Three-Dimensional Mass Spectrometry Imaging in Biomedical Research

scientific article published on 06 October 2020

Experimental investigation of the 2D ion beam profile generated by an ESI octopole-QMS system.

scientific article published on 12 August 2014

Fast, high resolution mass spectrometry imaging using a Medipix pixelated detector.

scientific article

Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Fiducial markers for combined 3-dimensional mass spectrometric and optical tissue imaging.

scientific article published on 7 February 2012

Fourier transform ion cyclotron resonance mass resolution and dynamic range limits calculated by computer modeling of ion cloud motion

scientific article published on 27 October 2011

Going forward: Increasing the accessibility of imaging mass spectrometry

scientific article (publication date: 30 August 2012)

Gold sputtered fiducial markers for combined secondary ion mass spectrometry and MALDI imaging of tissue samples.

scientific article

High dynamic range bio-molecular ion microscopy with the Timepix detector.

scientific article

High mass accuracy and high mass resolving power FT-ICR secondary ion mass spectrometry for biological tissue imaging

scientific article published on 19 May 2013

High resolution end group determination of low molecular weight polymers by matrix-assisted laser desorption ionization on an external ion source fourier transform ion cyclotron resonance mass spectrometer.

scientific article

High-reactivity matrices increase the sensitivity of matrix enhanced secondary ion mass spectrometry.

scientific article

High-resolution ion mobility spectrometry-mass spectrometry on poly(methyl methacrylate)

scientific article published on 01 December 2010

Higher sensitivity secondary ion mass spectrometry of biological molecules for high resolution, chemically specific imaging.

scientific article published on 12 June 2006

Host-based lipid inflammation drives pathogenesis in Francisella infection.

scientific article published on 6 November 2017

Hydrogen peroxide reactions on cocaine in hair using imaging mass spectrometry

scientific article

Identification of leptomeningeal metastasis-related proteins in cerebrospinal fluid of patients with breast cancer by a combination of MALDI-TOF, MALDI-FTICR and nanoLC-FTICR MS.

scientific article published in February 2007

Identification of pigments in paint cross sections by reflection visible light imaging microspectroscopy.

scientific article published on February 2003

Identifying tissue-specific signal variation in MALDI mass spectrometric imaging by use of an internal standard.

scientific article published on 24 December 2012

Imaging Isomers on a Biological Surface: A Review

scientific article published on 27 December 2019

Imaging mass spectrometry.

scientific article

Imaging of peptides in the rat brain using MALDI-FTICR mass spectrometry.

scientific article published on 19 October 2006

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches

scientific article published in Scientific Reports

Infrared mass spectrometric imaging below the diffraction limit.

scientific article published in May 2005

Integration of Ion Mobility MSE after Fully Automated, Online, High-Resolution Liquid Extraction Surface Analysis Micro-Liquid Chromatography

scientific article published on 25 September 2017

Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis

scientific article published on 24 January 2020

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on Aβ1-40 peptide early assembly

scientific article published on 12 August 2019

Isomer separation of hyperbranched polyesteramides with gas-phase H/D exchange and a novel MS(n) approach: DoDIP.

scientific article published in August 2002

Label-free characterization of biomembranes: from structure to dynamics.

scientific article published on February 2014

Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids.

scientific article

LipostarMSI: Comprehensive, Vendor-Neutral Software for Visualization, Data Analysis, and Automated Molecular Identification in Mass Spectrometry Imaging

scientific article published on 21 November 2019

Localized Hypoxia Results in Spatially Heterogeneous Metabolic Signatures in Breast Tumor Models ⬇️

scientific article published on August 1, 2012

Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation.

scientific article

MALDI mass spectrometry imaging in microscope mode with infrared lasers: bypassing the diffraction limits

scientific article published on 10 December 2013

MALDI-Mass Spectrometric Imaging Revealing Hypoxia-Driven Lipids and Proteins in a Breast Tumor Model

scientific article published on 4 June 2015

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

scientific article published on 05 August 2019

MS Imaging-guided Microproteomics for Spatial Omics on a Single Instrument

scientific article published on 07 August 2020

Mass Spectrometry Imaging with Isomeric Resolution Enabled by Ozone-Induced Dissociation

scientific article published on 19 June 2018

Mass Spectrometry Spatial-Omics on a Single Conductive Slide

scientific article published on 07 January 2021

Mass Spectrometry of Art and Cultural Heritage

article by Ester S. B. Ferreira et al published July 2009 in International Journal of Mass Spectrometry

Mass spectrometric imaging of red fluorescent protein in breast tumor xenografts.

scientific article

Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models.

scientific article published on 28 August 2012

Mass spectrometry imaging for clinical research - latest developments, applications, and current limitations.

scientific article published on 23 June 2017

Mass spectrometry imaging of biological tissue: an approach for multicenter studies

scientific article

Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage.

scientific article

Matrix-assisted laser desorption ionization mass spectrometry imaging for peptide and protein analyses: a critical review of on-tissue digestion

scientific article

Matrix-assisted laser desorption ionization-imaging mass spectrometry: a new methodology to study human osteoarthritic cartilage.

scientific article

Matrix-assisted laser desorption/ionization Fourier transform mass spectrometric analysis of oxygenated triglycerides and phosphatidylcholines in egg tempera paint dosimeters used for environmental monitoring of museum display conditions.

scientific article published in May 2001

Methods for full resolution data exploration and visualization for large 2D and 3D mass spectrometry imaging datasets

scholarly article by Ivo Klinkert et al published April 2014 in International Journal of Mass Spectrometry

Microscope mode secondary ion mass spectrometry imaging with a Timepix detector ⬇️

scientific article published on January 1, 2013

Molecular imaging of humain hair with MeV-SIMS: A case study of cocaine detection and distribution in the hair of a cocaine user

scientific article published on 25 March 2022

Monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry

article

Multilabel Per-Pixel Quantitation in Mass Spectrometry Imaging

scientific article published on 29 December 2020

Multiorder correction algorithms to remove image distortions from mass spectrometry imaging data sets.

scientific article

Nitromatrix provides improved LC-MALDI signals and more protein identifications.

scientific article

On-the-fly targeted selection of labeled peptides in liquid chromatography/mass spectrometry based quantitative proteomics

scientific article published on 01 January 2010

On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry.

scientific article

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI.

scientific article published on 20 July 2017

Parallel processing of large datasets from NanoLC-FTICR-MS measurements.

scientific article published on 19 October 2006

Performance of Orbitrap mass analyzer at various space charge and non-ideal field conditions: simulation approach

scientific article published on 22 February 2012

Precise Anatomic Localization of Accumulated Lipids in Mfp2 Deficient Murine Brains Through Automated Registration of SIMS Images to the Allen Brain Atlas

scientific article published on 28 April 2015

Preparation of longitudinal sections of hair samples for the analysis of cocaine by MALDI-MS/MS and TOF-SIMS imaging.

scientific article published on 18 May 2015

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

scientific article published on 27 April 2019

Protein classification and distribution in osteoarthritic human synovial tissue by matrix-assisted laser desorption ionization mass spectrometry imaging.

scientific article published on 13 December 2014

Protein identification with Liquid Chromatography and Matrix Enhanced Secondary Ion Mass Spectrometry (LC-ME-SIMS).

scientific article published on 17 February 2011

Proteomics analysis of human intestinal organoids during hypoxia and reoxygenation as a model to study ischemia-reperfusion injury

scientific article published on 18 January 2021

Quality of surface: The influence of sample preparation on MS-based biomolecular tissue imaging with MALDI-MS and (ME-)SIMS

Quantitative MALDI Tandem Mass Spectrometric Imaging of Cocaine from Brain Tissue with a Deuterated Internal Standard ⬇️

scientific article published on December 24, 2012

Radioactive Holmium Acetylacetonate Microspheres for Interstitial Microbrachytherapy: An In Vitro and In Vivo Stability Study ⬇️

scientific article published on November 9, 2011

Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging.

scientific article published on 15 February 2019

Secondary ion mass spectrometry imaging of Dictyostelium discoideum aggregation streams

scientific article published on 9 June 2014

Sequencing and Identification of Endogenous Neuropeptides with Matrix-Enhanced Secondary Ion Mass Spectrometry Tandem Mass Spectrometry.

scientific article published on 28 July 2017

Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue

scientific article published on 28 January 2020

Size, weight and position: ion mobility spectrometry and imaging MS combined.

scientific article

Software tools of the Computis European project to process mass spectrometry images.

scientific article published on January 2014

Solvent Effects on Differentiation of Mouse Brain Tissue Using Laser Microdissection 'Cut and Drop' Sampling with Direct Mass Spectral Analysis.

scientific article published on 3 January 2018

Sparse spectral techniques for emission imaging

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity.

scientific article published on 23 March 2018

Spatially resolved endogenous improved metabolite detection in human osteoarthritis cartilage by matrix assisted laser desorption ionization mass spectrometry imaging

scientific article published on 16 August 2019

Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging

scientific article published on 04 December 2018

Specific peptides identified by mass spectrometry in placental tissue from pregnancies complicated by early onset preeclampsia attained by laser capture dissection.

scientific article

Sphingolipids control dermal fibroblast heterogeneity

scientific article published on 15 April 2022

Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a fourier transform ion cyclotron resonance mass spectrometer

scientific article published on 01 June 2000

Subcellular imaging mass spectrometry of brain tissue.

scientific article published in February 2005

TOF-secondary ion mass spectrometry imaging of polymeric scaffolds with surrounding tissue after in vivo implantation.

scientific article published in June 2010

Tandem mass spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans ring.

scientific article

Targeted Drug and Metabolite Imaging: Desorption Electrospray Ionization combined with Triple Quadrupole Mass Spectrometry

article

The use of mass spectrometry imaging to predict treatment response of patient-derived xenograft models of triple-negative breast cancer.

scientific article published on 20 January 2015

Thermal activation of the co-chaperonins GroES and gp31 probed by mass spectrometry.

scientific article published in November 2008

Thermal energy distribution observed in electrospray ionization

scientific article published on 01 December 1999

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis

scientific article published on 18 February 2019

Three-dimensional molecular reconstruction of rat heart with mass spectrometry imaging

scientific article published on 11 October 2012

Time-resolved imaging of the MALDI linear-TOF ion cloud: direct visualization and exploitation of ion optical phenomena using a position- and time-sensitive detector.

scientific article

Tissue analysis with high-resolution imaging mass spectrometry.

scientific article

Tools and strategies for visualization of large image data sets in high-resolution imaging mass spectrometry.

scientific article

Top-down mass spectrometry imaging of intact proteins by laser ablation ESI FT-ICR MS.

scientific article

Toward digital staining using imaging mass spectrometry and random forests.

scientific article published on July 2009

Trends in mass spectrometry imaging for cardiovascular diseases

scientific article published on 12 April 2019

Ultra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

scientific article published on 03 February 2020

Using Matrix Peaks To Map Topography: Increased Mass Resolution and Enhanced Sensitivity in Chemical Imaging

article

Vacuum compatible sample positioning device for matrix assisted laser desorption∕ionization Fourier transform ion cyclotron resonance mass spectrometry imaging

scientific article

imzML--a common data format for the flexible exchange and processing of mass spectrometry imaging data.

scientific article

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