List of works - Gerardo Corzo

A Conus regularis conotoxin with a novel eight-cysteine framework inhibits CaV2.2 channels and displays an anti-nociceptive activity

scientific article published on 08 April 2013

A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels.

scientific article

A comparison between the recombinant expression and chemical synthesis of a short cysteine-rich insecticidal spider peptide.

scientific article published on 17 June 2015

A new theraphosid spider toxin causes early insect cell death by necrosis when expressed in vitro during recombinant baculovirus infection

scientific article

A pore forming peptide from spider Lachesana sp. venom induced neuronal depolarization and pain

scientific article published on 5 December 2014

A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K+ channels responsible for the IA currents in cerebellum granular cells.

scientific article

A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus.

scientific article published on 22 August 2008

Addition of positive charges at the C-terminal peptide region of CssII, a mammalian scorpion peptide toxin, improves its affinity for sodium channels Nav1.6

scientific article

Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index.

scientific article

An Insight into the Triabin Protein Family of American Hematophagous Reduviids: Functional, Structural and Phylogenetic Analysis

scientific article published on 15 February 2016

An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera.

scientific article

An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus

scientific article published in 2024

An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis.

scientific article

Antibacterial activity and phospholipid recognition of the recombinant defensin J1-1 from Capsicum genus.

scientific article published on 14 June 2017

Antimicrobial Activity and Stability of Short and Long Based Arachnid Synthetic Peptides in the Presence of Commercial Antibiotics.

scientific article

Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis

scientific article published on 09 November 2020

Antimicrobial activity and structure of a consensus human β-defensin and its comparison to a novel putative hBD10

scientific article published on 30 July 2019

Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics.

scientific article

Bacterial expression and antibiotic activities of recombinant variants of human β-defensins on pathogenic bacteria and M. tuberculosis.

scientific article

Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels.

scientific article

Characterization of antibacterial and hemolytic activity of synthetic pandinin 2 variants and their inhibition against Mycobacterium tuberculosis.

scientific article

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.

scientific article

Cloning and sequencing of three-finger toxins from the venom glands of four Micrurus species from Mexico and heterologous expression of an alpha-neurotoxin from Micrurus diastema.

scientific article

Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative "hot spot" common to all scorpion beta-toxins affecting Na+ channels.

scientific article published on 12 December 2003

Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.

scientific article

Effective Design of Multifunctional Peptides by Combining Compatible Functions

scientific article

Enhanced Tolerance against a Fungal Pathogen and Insect Resistance in Transgenic Tobacco Plants Overexpressing an Endochitinase Gene from Serratia marcescens

scientific article published on 16 July 2019

Exploiting cross-reactivity to neutralize two different scorpion venoms with one single chain antibody fragment

scientific article

Expression systems of human β-defensins: vectors, purification and biological activities.

scientific article published on 20 March 2010

Four disulfide-bridged scorpion beta neurotoxin CssII: heterologous expression and proper folding in vitro

scientific article published on May 2007

Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae

scientific article

Giant fish-killing water bug reveals ancient and dynamic venom evolution in Heteroptera.

scientific article published on 9 February 2018

Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus.

scientific article

Heterologous expression of five disulfide-bonded insecticidal spider peptides.

scientific article published on 2 June 2016

Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis

scientific article

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

scientific article published on 13 August 2019

Immunogenic Properties of Recombinant Enzymes from Bothrops Ammodytoides Towards the Generation of Neutralizing Antibodies against Its Own Venom

scientific article published on 02 December 2019

Improved protease stability of the antimicrobial peptide Pin2 substituted with D-amino acids.

scientific article published on August 2013

Induction of morphological changes in model lipid membranes and the mechanism of membrane disruption by a large scorpion-derived pore-forming peptide.

scientific article

Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2

scientific article

Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K+ channels in cerebellum granular cells

scientific article published in September 2014

IsCT, a novel cytotoxic linear peptide from scorpion Opisthacanthus madagascariensis.

scientific article published in August 2001

Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus.

scientific article

Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).

scientific article

Key amino acid residues involved in mammalian and insecticidal activities of Magi4 and Hv1b, cysteine-rich spider peptides from the δ-atracotoxin family

scientific article published on 17 February 2020

Molecular cloning and biochemical characterization of the first Na(+)-channel α-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom.

scientific article published on 5 February 2013

Molecular dynamics simulation of the membrane binding and disruption mechanisms by antimicrobial scorpion venom-derived peptides.

scientific article

N-acyl amino acid biosynthesis in marine bacterium, Deleya marina

scientific article published on 01 July 1997

Negative-shift activation, current reduction and resurgent currents induced by β-toxins from Centruroides scorpions in sodium channels.

scientific article

Nonenzymatically oxidized arachidonic acid regulates T-type Ca2+ currents in mouse spermatogenic cells

scientific article published on 06 June 2019

Novel peptides from assassin bugs (Hemiptera: Reduviidae): isolation, chemical and biological characterization.

scientific article

Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.

scientific article

Panusin represents a new family of β-defensin-like peptides in invertebrates

scientific article

Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity.

scientific article published on 4 September 2015

Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size.

scientific article

Pore-forming spider venom peptides show cytotoxicity to hyperpolarized cancer cells expressing K+ channels: A lentiviral vector approach

scientific article published on 12 April 2019

Proteomic and transcriptomic analysis of saliva components from the hematophagous reduviid Triatoma pallidipennis

scientific article

Purification and cDNA cloning of a novel neurotoxic peptide (Acra3) from the scorpion Androctonus crassicauda.

scientific article

Rapid and efficient identification of cysteine-rich peptides by random screening of a venom gland cDNA library from the hexathelid spider Macrothele gigas.

scientific article

Scorpion and spider venom peptides: gene cloning and peptide expression.

scientific article

Scorpion toxins that block transient currents (I(A)) of rat cerebellum granular cells

scientific article

Scorpion venom peptides without disulfide bridges.

scientific article

Selected scorpion toxin exposures induce cytokine release in human peripheral blood mononuclear cells.

scientific article published on 11 January 2017

Short-chain consensus alpha-neurotoxin: a synthetic 60-mer peptide with generic traits and enhanced immunogenic properties

scientific article published on 6 April 2018

Solution Structure of Ptu1, a Toxin from the Assassin Bug Peirates turpis That Blocks the Voltage-Sensitive Calcium Channel N-Type ⬇️

scientific article published on October 30, 2001

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels

scientific article

Solution structure of ADO1, a toxin extracted from the saliva of the assassin bug, Agriosphodrus dohrni

scientific article

Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus

scientific article

Solution structure of discrepin, a new K+-channel blocking peptide from the alpha-KTx15 subfamily.

scientific article

Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 sodium channels

scientific article

Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs

scientific article

Successful refolding and NMR structure of rMagi3: a disulfide-rich insecticidal spider toxin.

scientific article published on 16 December 2017

Synthesis and paralytic activities of squaryl amino acid-containing polyamine toxins.

scientific article published in April 2003

Synthetic peptide antigens derived from long-chain alpha-neurotoxins: Immunogenicity effect against elapid venoms.

scientific article published on 20 December 2016

The effect of binding of spider-derived antimicrobial peptides, oxyopinins, on lipid membranes

scientific article published on 19 May 2006

The trypsin inhibitor panulirin regulates the prophenoloxidase-activating system in the spiny lobster Panulirus argus.

scientific article

The unique pharmacology of the scorpion alpha-like toxin Lqh3 is associated with its flexible C-tail.

scientific article published on 9 March 2007

Transcriptomic Analysis of the Venom Gland and Enzymatic Characterization of the Venom of <i>Phoneutria depilata</i> (Ctenidae) from Colombia

scientific article published on 21 April 2022

Venoms of Centruroides and Tityus species from Panama and their main toxic fractions.

scientific article published on 28 November 2017

cDNA cloning, heterologous expression, protein folding and immunogenic properties of a phospholipase A2 from Bothrops ammodytoides venom

scientific article published on 08 September 2018

List of works by Gerardo Corzo

A Conus regularis conotoxin with a novel eight-cysteine framework inhibits CaV2.2 channels and displays an anti-nociceptive activity

A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels.

A comparison between the recombinant expression and chemical synthesis of a short cysteine-rich insecticidal spider peptide.

A new theraphosid spider toxin causes early insect cell death by necrosis when expressed in vitro during recombinant baculovirus infection

A pore forming peptide from spider Lachesana sp. venom induced neuronal depolarization and pain

A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K+ channels responsible for the IA currents in cerebellum granular cells.

A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus.

Addition of positive charges at the C-terminal peptide region of CssII, a mammalian scorpion peptide toxin, improves its affinity for sodium channels Nav1.6

Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index.

An Insight into the Triabin Protein Family of American Hematophagous Reduviids: Functional, Structural and Phylogenetic Analysis

An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera.

An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus, and Tityus n. sp. aff. metuendus

An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis.

Antibacterial activity and phospholipid recognition of the recombinant defensin J1-1 from Capsicum genus.

Antimicrobial Activity and Stability of Short and Long Based Arachnid Synthetic Peptides in the Presence of Commercial Antibiotics.

Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis

Antimicrobial activity and structure of a consensus human β-defensin and its comparison to a novel putative hBD10

Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics.

Bacterial expression and antibiotic activities of recombinant variants of human β-defensins on pathogenic bacteria and M. tuberculosis.

Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels.

Characterization of antibacterial and hemolytic activity of synthetic pandinin 2 variants and their inhibition against Mycobacterium tuberculosis.

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.

Cloning and sequencing of three-finger toxins from the venom glands of four Micrurus species from Mexico and heterologous expression of an alpha-neurotoxin from Micrurus diastema.

Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative "hot spot" common to all scorpion beta-toxins affecting Na+ channels.

Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.

Effective Design of Multifunctional Peptides by Combining Compatible Functions

Enhanced Tolerance against a Fungal Pathogen and Insect Resistance in Transgenic Tobacco Plants Overexpressing an Endochitinase Gene from Serratia marcescens

Exploiting cross-reactivity to neutralize two different scorpion venoms with one single chain antibody fragment

Expression systems of human β-defensins: vectors, purification and biological activities.

Four disulfide-bridged scorpion beta neurotoxin CssII: heterologous expression and proper folding in vitro

Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae

Giant fish-killing water bug reveals ancient and dynamic venom evolution in Heteroptera.

Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus.

Heterologous expression of five disulfide-bonded insecticidal spider peptides.

Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Immunogenic Properties of Recombinant Enzymes from Bothrops Ammodytoides Towards the Generation of Neutralizing Antibodies against Its Own Venom

Improved protease stability of the antimicrobial peptide Pin2 substituted with D-amino acids.

Induction of morphological changes in model lipid membranes and the mechanism of membrane disruption by a large scorpion-derived pore-forming peptide.

Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2

Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K+ channels in cerebellum granular cells

IsCT, a novel cytotoxic linear peptide from scorpion Opisthacanthus madagascariensis.

Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus.

Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).

Key amino acid residues involved in mammalian and insecticidal activities of Magi4 and Hv1b, cysteine-rich spider peptides from the δ-atracotoxin family

Molecular cloning and biochemical characterization of the first Na(+)-channel α-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom.

Molecular dynamics simulation of the membrane binding and disruption mechanisms by antimicrobial scorpion venom-derived peptides.

N-acyl amino acid biosynthesis in marine bacterium, Deleya marina

Negative-shift activation, current reduction and resurgent currents induced by β-toxins from Centruroides scorpions in sodium channels.

Nonenzymatically oxidized arachidonic acid regulates T-type Ca2+ currents in mouse spermatogenic cells

Novel peptides from assassin bugs (Hemiptera: Reduviidae): isolation, chemical and biological characterization.

Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.

Panusin represents a new family of β-defensin-like peptides in invertebrates

Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity.

Pore formation of phospholipid membranes by the action of two hemolytic arachnid peptides of different size.

Pore-forming spider venom peptides show cytotoxicity to hyperpolarized cancer cells expressing K+ channels: A lentiviral vector approach

Proteomic and transcriptomic analysis of saliva components from the hematophagous reduviid Triatoma pallidipennis

Purification and cDNA cloning of a novel neurotoxic peptide (Acra3) from the scorpion Androctonus crassicauda.

Rapid and efficient identification of cysteine-rich peptides by random screening of a venom gland cDNA library from the hexathelid spider Macrothele gigas.

Scorpion and spider venom peptides: gene cloning and peptide expression.

Scorpion toxins that block transient currents (I(A)) of rat cerebellum granular cells

Scorpion venom peptides without disulfide bridges.

Selected scorpion toxin exposures induce cytokine release in human peripheral blood mononuclear cells.

Short-chain consensus alpha-neurotoxin: a synthetic 60-mer peptide with generic traits and enhanced immunogenic properties

Solution Structure of Ptu1, a Toxin from the Assassin Bug Peirates turpis That Blocks the Voltage-Sensitive Calcium Channel N-Type ⬇️

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels

Solution structure of ADO1, a toxin extracted from the saliva of the assassin bug, Agriosphodrus dohrni

Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus

Solution structure of discrepin, a new K+-channel blocking peptide from the alpha-KTx15 subfamily.

Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 sodium channels

Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs

Successful refolding and NMR structure of rMagi3: a disulfide-rich insecticidal spider toxin.

Synthesis and paralytic activities of squaryl amino acid-containing polyamine toxins.

Synthetic peptide antigens derived from long-chain alpha-neurotoxins: Immunogenicity effect against elapid venoms.

The effect of binding of spider-derived antimicrobial peptides, oxyopinins, on lipid membranes

The trypsin inhibitor panulirin regulates the prophenoloxidase-activating system in the spiny lobster Panulirus argus.

The unique pharmacology of the scorpion alpha-like toxin Lqh3 is associated with its flexible C-tail.

Transcriptomic Analysis of the Venom Gland and Enzymatic Characterization of the Venom of <i>Phoneutria depilata</i> (Ctenidae) from Colombia

Venoms of Centruroides and Tityus species from Panama and their main toxic fractions.