List of works by Hiroshi Seno

A Rare Case of Lymph Node Metastasis from Early Gastric Cancer

scientific article published on 05 October 2018

A case of a malignant serous neoplasm of the pancreas with synchronous vascular invasion and metachronous metastases

scientific article published on 03 September 2020

A case of acute necrotizing esophagitis

scientific article published on 13 May 2014

A case of cecocolonic intussusception after endoscopic submucosal dissection of a cecal adenoma.

scientific article published on 6 December 2017

A novel endoscopic imaging system for quantitative evaluation of colonic mucosal inflammation in patients with quiescent ulcerative colitis

scientific article published on 08 January 2020

A novel technique for mapping biopsy of bile duct cancer

scientific article published on 22 September 2020

A novel technique for performing gallbladder tumor biopsy using a stent delivery system and biopsy forceps

scientific article published on 24 April 2020

ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.

scientific article published on 28 March 2018

Accelerated Progression of Hepatocellular Carcinoma during Immunosuppressive Therapy with Abatacept for Rheumatoid Arthritis

scientific article published on 24 August 2018

Activation of TNF-α-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B.

scientific article published on 4 January 2017

Acute Anorectal Thrombophlebitis Caused by a Protein C Deficiency

scientific article published on 16 October 2017

Adenomyoma of the minor duodenal papilla

scientific article published on 01 March 2005

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

scientific article published on 02 January 2019

An irregular-shaped stenosis of the sigmoid colon

scientific article published on 19 December 2013

An unusual cause of dysphagia after endoscopic resection of an early esophageal cancer

scientific article published on 11 May 2011

Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes.

scientific article published on 10 January 2006

Arid1a is essential for intestinal stem cells through Sox9 regulation

scientific article published on 11 January 2019

Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next-Generation Sequencing-Based Multiplex Gene Panel Assay

scientific article published on 11 June 2019

Association of Mac-2-binding protein glycosylation isomer level with nutritional status in chronic liver disease

scientific article published on 22 February 2018

Bmi1 marks gastric stem cells located in the isthmus in mice

scientific article published on 20 February 2019

Branched-chain amino acid to tyrosine ratio is an essential pre-treatment factor for maintaining sufficient treatment intensity of lenvatinib in patients with hepatocellular carcinoma

scientific article published on 07 September 2020

Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling

scientific article

COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps

scientific article published on 05 July 2011

CXCR4 in tumor epithelial cells mediates desmoplastic reaction in pancreatic ductal adenocarcinoma

scientific article published on 30 June 2020

Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine

scientific article

Catheter US probe EUS evaluation of gastric cardia and perigastric vascular structures to predict esophageal variceal recurrence

scientific article published in February 2002

Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice.

scientific article

Choledochoduodenal Fistula during Chemotherapy with Brentuximab Vedotin for Methotrexate-associated Lymphoproliferative Disorder

scientific article published on 09 March 2018

Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors.

scientific article

Colonic findings in Churg-Strauss syndrome.

scientific article published on 25 June 2013

Colonoscopic classification of internal hemorrhoids: usefulness in endoscopic band ligation

scientific article published in January 2005

Combination of Mac-2 Binding Protein Glycosylation Isomer and Up-To-Seven Criteria as a Useful Predictor for Child-Pugh Grade Deterioration after Transarterial Chemoembolization for Hepatocellular Carcinoma

scientific article published on 22 March 2019

Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.

scientific article

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis

scientific article published on 12 February 2019

Conversion from latent to symptomatic Sheehan's syndrome by pegylated interferon therapy for chronic hepatitis C.

scientific article published on 15 May 2008

Current status of treatment with immune checkpoint inhibitors for gastrointestinal, hepatobiliary, and pancreatic cancers

scientific article published on 21 August 2020

Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps

scientific journal article

Cyclooxygenase-2 expression and angiogenesis in gastric hyperplastic polyp--association with polyp size

scientific article published on 01 January 2003

DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis

scientific article published on 04 December 2020

Dclk1 distinguishes between tumor and normal stem cells in the intestine

scientific article published on 2 December 2012

Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes

scientific article

Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment

scientific article published on 22 November 2019

Diagnostic performance of a new endoscopic scraper for malignant biliary strictures: a multicenter prospective study

scientific article

Disease severity is linked to an increase in autoantibody diversity in IgG4-related disease: comment on the article by Liu H et al

scientific article published on 10 June 2020

Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine.

scientific article published on 23 May 2017

Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.

scientific article

Dose Intensity/Body Surface Area Ratio is a Novel Marker Useful for Predicting Response to Lenvatinib against Hepatocellular Carcinoma

scientific article published on 22 December 2019

EP4 Receptor-Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis

scientific article published on 6 October 2015

Education and imaging. Gastrointestinal: breast cancer metastasis to the esophagus diagnosed using endoscopic ultrasound-guided fine-needle aspiration.

scientific article

Efficacy and safety of glecaprevir and pibrentasvir treatment for 8 or 12 weeks in patients with recurrent hepatitis C after liver transplantation: a Japanese multicenter experience

scientific article published on 26 February 2019

Efficacy of an implanted drug delivery system for advanced hepatocellular carcinoma using 5-fluorouracil, epirubicin and mitomycin C

scientific article published on 01 August 1999

Efficient colonic mucosal wound repair requires Trem2 signaling

scholarly article

Endoscopic intraluminal cutting technique for indwelling devices using a lithotripter handle and guidewire

scientific article published on 22 June 2015

Endoscopic stone extraction for choledocholithiasis with an ultra-slim endoscope via a gastrostomy after esophagectomy

scientific article published on 24 June 2020

Endoscopic ultrasonograph evaluation of vascular structures in the gastric cardia predicts esophageal variceal recurrence following endoscopic treatment.

scientific article published in January 2006

Enhanced expression of transforming growth factor (TGF) -alpha precursor and TGF-beta1 during Paneth cell regeneration

scientific article

Epithelial EP4 plays an essential role in maintaining homeostasis in colon

scientific article published on 23 October 2019

Esophageal ulcer due to lymphoma

scientific article published on 15 November 2014

Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer

scientific article published on 03 May 2022

Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing

scientific article

Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection

scientific article published in Scientific Reports

Exposure-toxicity relationship of sorafenib in Japanese patients with renal cell carcinoma and hepatocellular carcinoma

scientific article

Expression of reg I alpha protein in human gastric cancers.

scientific article published on 27 May 2004

Expression of the REG IV gene in ulcerative colitis

scientific article

Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

scientific article published on 18 December 2019

Gastric Cancer from a Hyperplastic Polyp on an Endoscopic Submucosal Dissection Scar.

scientific article published on 18 December 2018

Gastrointestinal: An unusual cause of thickening of the rectal wall

scientific article published on 01 April 2018

Gastrointestinal: Lanthanum phosphate deposition in the gastroduodenal mucosa: An unusual cause of epigastric discomfort

scientific article published on 30 March 2018

Gene expression profile of Dclk1+ cells in intestinal tumors

scientific article published on 22 June 2018

Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer

scientific article published on 12 December 2018

Genetic features of multicentric/multifocal intramucosal gastric carcinoma.

scientific article

Glucocorticoid receptor expression in resident and hematopoietic cells in IgG4-related disease.

scientific article published on 12 February 2018

Group cognitive behavioural therapy (GCBT) versus treatment as usual (TAU) in the treatment of irritable bowel syndrome (IBS): a study protocol for a randomized controlled trial

scientific article published on 04 February 2020

Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway

scientific article published on February 2007

Growth promoting effect of thioredoxin on intestinal epithelial cells.

scientific article

Hepatitis B virus infection in lymphatic tissues in inactive hepatitis B carriers.

scientific article

Hepatitis C Treatment with Sofosbuvir and Ledipasvir Accompanied by Immediate Improvement in Hemoglobin A1c.

scientific article

Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis

scientific article published on 26 December 2019

Hepatobiliary and Pancreatic: Granulomatous hepatitis due to disseminated bacillus Calmette-Guérin disease.

scientific article

Hes1 is essential in proliferating ductal cell-mediated development of intrahepatic cholangiocarcinoma

scientific article published on 16 October 2020

Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis

scientific article published on 31 January 2019

Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine

scientific article published on 01 March 2005

High prevalence of anti-hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan

scientific article

Host factors are important in determining clinical outcomes of Helicobacter pylori infection.

scientific article

Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway.

scientific article published on 23 January 2006

Identification of GM-CSF in Paneth cells using single-cell RT-PCR.

scientific article

Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells.

scientific article

Identification of modules and functional analysis in CRC subtypes by integrated bioinformatics analysis

scientific article published on 30 August 2019

Identification of xanthine dehydrogenase/xanthine oxidase as a rat Paneth cell zinc-binding protein

scientific article published in July 2001

Images of the Month: A Polypoid Lesion in the Portal Vein.

scientific article published in June 2015

Improvement of collateral vessels in the vicinity of gastric cardia after endoscopic variceal ligation therapy for esophageal varices.

scientific article published in May 2004

Indigenous clostridium species regulate systemic immune responses by induction of colonic regulatory T cells

scientific article published on 24 July 2011

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.

scientific article published on 17 November 2016

Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells.

scientific article

Inhibitory role of Gas6 in intestinal tumorigenesis.

scientific article published on 20 February 2013

Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intraepithelial lymphocytes in the intestine

scientific article published on 26 December 2019

Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice.

scientific article

Involvement of gene abnormalities in the development of digestive diseases

scientific article published on January 2016

Involvement of tumor necrosis factor alpha in intestinal epithelial cell proliferation following Paneth cell destruction

scientific article published in February 2002

Ischemic duodenitis

scientific article published on 01 January 2005

Jejunal diaphragm disease associated with cytomegalovirus infection

Key molecules in metaplastic gastritis: sequential analysis of CDX1/2 homeobox gene expression

scientific article published on 01 January 2002

Laminin 511 is a target antigen in autoimmune pancreatitis

scientific article published on 01 August 2018

Laparoscopic liver resection versus percutaneous radiofrequency ablation for small hepatocellular carcinoma

scientific article published on 07 September 2020

Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells

scientific article published on 10 June 2019

Long-term Prognosis and Recurrence of Primary Sclerosing Cholangitis After Liver Transplantation: A Single-Center Experience.

scientific article published on 20 November 2017

Measurement bias of colorectal polyp size: Analysis of the Japan Endoscopy Database

scientific article published on 13 June 2019

Mechanism for gastric cancer development by Helicobacter pylori infection.

scientific article published on 10 June 2008

Metastatic gastrointestinal stromal tumors mimicking gastrointestinal polyposis

scientific article published on 13 January 2010

Molecular changes leading to gastric cancer: a suggestion from rare-type gastric tumors with GNAS mutations

scientific article published on 25 March 2014

Multiple roles of SIM2 in esophageal squamous cell carcinoma and its clinical implications.

scientific article published on 10 February 2018

Multiregional whole-genome sequencing of hepatocellular carcinoma with nodule-in-nodule appearance reveals stepwise cancer evolution

scientific article published on 20 August 2020

Mutational spectrum of hepatitis C virus in patients with chronic hepatitis C determined by single molecule real-time sequencing

scientific article published on 30 April 2022

Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α.

scientific article

Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.

scientific article published on 19 April 2018

Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice

article published in 2018

Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice

Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach

scientific article

Non-clinical efficacy, safety and stable clinical cell processing of induced pluripotent stem cell-derived anti-glypican-3 chimeric antigen receptor-expressing natural killer/innate lymphoid cells

scientific article published on 04 March 2020

Novel interleukin-4 and interleukin-1 receptor antagonist gene variations associated with non-cardia gastric cancer in Japan: comprehensive analysis of 207 polymorphisms of 11 cytokine genes

scientific article published on 01 May 2007

Paraplegia as an initial manifestation of pancreatic cancer

scientific article published on 14 May 2019

Pathogenicity of IgG in patients with IgG4-related disease.

scientific article published on 10 March 2016

Perivascular epithelioid cell tumor (PEComa) of the liver diagnosed by contrast-enhanced ultrasonography.

scientific article

Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis

scientific article published on 04 January 2020

Portal vein thrombosis due to essential thrombocythemia with limited cutaneous systemic sclerosis

scientific article published on 02 November 2020

Primary splenic angiosarcoma

scientific article published on 01 August 2014

Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma

scientific article published on 26 September 2017

Promoter-Level Transcriptome Identifies Stemness Associated With Relatively High Proliferation in Pancreatic Cancer Cells

scientific article published on 20 March 2020

Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice

scientific article published on 10 May 2019

Pulmonary actinomycosis mimicking a lung metastasis from esophageal cancer; a case report.

scientific article

Qualitative and Quantitative Analysis of Posttreatment Strategy After Endoscopic Resection for Patients with T1 Colorectal Cancer at High Risk of Lymph Node Metastasis

scientific article published on 01 March 2020

REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.

scientific article

Rapid development of diffuse large B-Cell lymphoma after successful eradication of Helicobacter pylori for gastric MALT lymphoma

scientific article published on 06 October 2006

Rb and p53 execute distinct roles in the development of pancreatic neuroendocrine tumors

scientific article published on 26 June 2020

Real-time quantitative PCR analysis of endoscopic biopsies for diagnosing CMV gastrointestinal disease in non-HIV immunocompromised patients: a diagnostic accuracy study

article

Recent Advances in Immunotherapy for Hepatocellular Carcinoma

scientific article published on 25 March 2020

Refractory enterovesical and duodenocolic fistulas in Crohn's disease successfully managed with tacrolimus

scientific article published in April 2005

Regression of fundic gland polyps following acquisition of Helicobacter pylori

scientific article

Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite.

scientific article published in April 2008

SETDB1 Inhibits p53-Mediated Apoptosis and is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice

scientific article published on 28 April 2020

SNAIL regulates gastric carcinogenesis through CCN3 and NEFL

scientific article published on 12 December 2020

STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.

scientific article published on June 2004

Segmental xanthomatosis of the ileum

scientific article published on 20 January 2018

Short educational video to improve the accuracy of colorectal polyp size estimation: Multicenter prospective study

scientific article published on 28 January 2020

Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer

scientific article published on March 2006

Single-molecular real-time deep sequencing reveals the dynamics of multi-drug resistant haplotypes and structural variations in the hepatitis C virus genome

scientific article published on 14 February 2020

Skull metastasis from cholangiolocellular carcinoma

scientific article published on 04 April 2017

Sonazoid-enhanced ultrasonography guidance improves the quality of pathological diagnosis in the biopsy of focal hepatic lesions.

scientific article

Spontaneous regression of mismatch repair deficient colorectal cancers: a case series

scientific article published on 16 May 2020

Steeper steps and pledge for inevitable responsibilities

scientific article published on 01 January 2020

Successful endoscopic removal of fractured guidewire fragments from a peripheral bile duct using a biliary stent delivery system and biopsy forceps

scientific article published on 03 July 2018

Th response to Helicobacter pylori differs between patients with gastric ulcer and duodenal ulcer

scientific article published on 01 June 2005

The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis

article by Motoyuki Tsuda et al published 1 August 2018 in Journal of Clinical Investigation

The Efficacy of Sonazoid-enhanced Ultrasonography in Decision-making for Liver Abscess Treatment

scientific article published on 15 February 2020

The role of CXCR3 and CXCR4 in colorectal cancer metastasis.

scientific article

The role of Hes genes in intestinal development, homeostasis and tumor formation.

scientific article published on 8 February 2012

The role of SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma

scientific article published on 10 December 2020

The use of hepatitis B immunoglobulin with or without hepatitis B vaccine to prevent de novo hepatitis B in pediatric recipients of anti-HBc-positive livers.

scientific article

Tumor invasion to the arteries feeding the gallbladder as a novel risk factor for cholecystitis after metallic stent placement in distal malignant biliary obstruction

scientific article published on 27 November 2017

Twelve-year natural history of early esophagogastric junction cancer in an extremely old patient

scientific article published on 01 December 2018

Two cases of acute necrotizing pancreatitis complicating after transcatheter arterial embolization for hepatocellular carcinoma.

scientific article published in January 2005

Ultrasound-guided microfoam sclerotherapy with polidocanol for symptomatic giant hepatic cyst: Initial experience

scientific article published on 10 July 2018

Unveiling epigenetic regulation in cancer, aging, and rejuvenation with in vivo reprogramming technology

scientific article published on 15 August 2018

Updated Trends in Gallbladder and Other Biliary Tract Cancers Worldwide

scientific article published on 22 November 2017

Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report.

scientific article published in December 2017

Utility of laser-cut covered self-expandable metal stents for unresectable malignant distal biliary obstruction: a single-center experience

scientific article published on 21 April 2020

Utility of ultrasound-guided liver tumor biopsy for next-generation sequencing-based clinical sequencing

scientific article published on 07 February 2019

Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes.

scientific article published on 12 January 2009

Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40-69-years subjects

scientific article published on 12 June 2021

Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

scientific article published on 04 January 2021

[A tumor stem cell-specific marker identified by lineage tracing in the intestine].

scientific article

[Evaluation of the safety and efficacy of endoscopic treatment for early gastric cancers in patients aged over 80 years]

scientific article published on 01 January 2018

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