List of works - Tarek Moustafa

125 SIDE CHAIN MODIFIED BILE ACIDS MODULATE ENDOPLASMIC RETICULUM STRESS IN MDR2−/− MICE IN VIVO AND BILE DUCT EPITHELIAL CELLS IN VITRO

320 3.5-Diethoxycarbonyl-1.4-dihydrocollidine (DDC) feeding induces cholestasis, chronic inflammatory bile duct damage and biliary fibrosis in mice

321 Role of nuclear bile acid receptor FXR in regulation of bile acid detoxification and organic solute transporter (OST-α/β) expression in bile acid-fed mice

62 Common bile-duct-ligation of FXR knockout mice results in severe hepatic steatosis due to enhancement in lipogenic gene expression

article

94 Transcriptional profiling of MDR2 knockout (MDR2−/−) mice treated with NOR-UDCA reveals global anti-inflammatory and anti-fibrotic effects

98 DIFFERENTIAL EFFECTS OF NORUDCA AND UDCA IN THE TREATMENT OF FATTY LIVER AND ARTERIOSCLEROSIS IN WESTERN CHOW-FED APOE KNOCK OUT MICE

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis

scientific article

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

scientific article published on 21 August 2011

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

scientific article published on 30 January 2014

Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A.

scientific article published on 16 January 2014

Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.

scientific article

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

scientific article

Bile acids as regulators of hepatic lipid and glucose metabolism

scientific article published on 07 May 2010

Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice

scientific article

Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.

scientific article

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids

scientific article published on 15 December 2005

Differential effects of norUDCA and UDCA in obstructive cholestasis in mice

scientific article published on 29 January 2013

Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts

scientific article

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis

scientific article

G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.

scientific article published on 8 September 2015

Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases

scientific article

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover

scientific article published on 27 June 2016

New insights into autoimmune cholangitis through animal models

scientific article published on 07 May 2010

Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan

scientific article published on March 2014

PCK2 activation mediates an adaptive response to glucose depletion in lung cancer

scientific article (publication date: 19 February 2015)

Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders.

scientific article published on 27 May 2015

Primary sclerosing cholangitis--the arteriosclerosis of the bile duct?

scientific article published on 25 January 2007

Primary sclerosing cholangitis: new approaches to diagnosis, surveillance and treatment

scientific article published on 11 October 2012

Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice

scientific article published on 11 April 2008

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

scientific article published on 02 November 2011

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice

scientific article

TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae

scientific article

Targeting nuclear bile acid receptors for liver disease

scientific article published on 17 June 2011

The gut bacterium <i>Extibacter muris</i> produces secondary bile acids and influences liver physiology in gnotobiotic mice

scientific article published on 01 January 2021

The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice

scientific article

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

scientific article

Validated Comprehensive Analytical Method for Quantification of Coenzyme A Activated Compounds in Biological Tissues by Online Solid-Phase Extraction LC/MS/MS

scientific article published on 09 July 2008

[307] TNFo AND LPS BUT NOT BILE ACIDS PLAY A KEY ROLE IN THE INDUCTION OF REACTIVE PHENOTYPE IN BILE DUCT EPITHELIAL CELLS IN VITRO

[48] RETENTION OF TOXIC BILE ACIDS ACTIVATE THE MTOR, P70S6K/RPS6 SIGNALING PATHWAY IN MOUSE MODELS OF CHOLESTATIC LIVER INJURY

article

[5] ABSENCE OF FXR PROTECTS MICE FROM BILE-INFARCTS IN BILIARY OBSTRUCTION BY REDUCTION OF BILE ACID-INDEPENDENT BILE FLOW: IMPLICATIONS FOR TARGETING FXR IN TREATMENT OF CHOLESTASIS?

List of works by Tarek Moustafa

125 SIDE CHAIN MODIFIED BILE ACIDS MODULATE ENDOPLASMIC RETICULUM STRESS IN MDR2−/− MICE IN VIVO AND BILE DUCT EPITHELIAL CELLS IN VITRO

320 3.5-Diethoxycarbonyl-1.4-dihydrocollidine (DDC) feeding induces cholestasis, chronic inflammatory bile duct damage and biliary fibrosis in mice

321 Role of nuclear bile acid receptor FXR in regulation of bile acid detoxification and organic solute transporter (OST-α/β) expression in bile acid-fed mice

62 Common bile-duct-ligation of FXR knockout mice results in severe hepatic steatosis due to enhancement in lipogenic gene expression

94 Transcriptional profiling of MDR2 knockout (MDR2−/−) mice treated with NOR-UDCA reveals global anti-inflammatory and anti-fibrotic effects

98 DIFFERENTIAL EFFECTS OF NORUDCA AND UDCA IN THE TREATMENT OF FATTY LIVER AND ARTERIOSCLEROSIS IN WESTERN CHOW-FED APOE KNOCK OUT MICE

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A.

Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.

Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

Bile acids as regulators of hepatic lipid and glucose metabolism

Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice

Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids

Differential effects of norUDCA and UDCA in obstructive cholestasis in mice

Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis

G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.

Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover

New insights into autoimmune cholangitis through animal models

Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan

PCK2 activation mediates an adaptive response to glucose depletion in lung cancer

Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders.

Primary sclerosing cholangitis--the arteriosclerosis of the bile duct?

Primary sclerosing cholangitis: new approaches to diagnosis, surveillance and treatment

Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice

TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae

Targeting nuclear bile acid receptors for liver disease

The gut bacterium <i>Extibacter muris</i> produces secondary bile acids and influences liver physiology in gnotobiotic mice

The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

Validated Comprehensive Analytical Method for Quantification of Coenzyme A Activated Compounds in Biological Tissues by Online Solid-Phase Extraction LC/MS/MS

[307] TNFo AND LPS BUT NOT BILE ACIDS PLAY A KEY ROLE IN THE INDUCTION OF REACTIVE PHENOTYPE IN BILE DUCT EPITHELIAL CELLS IN VITRO

[48] RETENTION OF TOXIC BILE ACIDS ACTIVATE THE MTOR, P70S6K/RPS6 SIGNALING PATHWAY IN MOUSE MODELS OF CHOLESTATIC LIVER INJURY

[5] ABSENCE OF FXR PROTECTS MICE FROM BILE-INFARCTS IN BILIARY OBSTRUCTION BY REDUCTION OF BILE ACID-INDEPENDENT BILE FLOW: IMPLICATIONS FOR TARGETING FXR IN TREATMENT OF CHOLESTASIS?