List of works - Cecilia M. Borghese

A transmembrane site determines sensitivity of neuronal nicotinic acetylcholine receptors to general anesthetics.

scientific article

An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice

scientific article (publication date: October 2006)

Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.

scientific article

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

scientific article published on 28 October 2011

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels

scientific article published on 15 August 2013

GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

scientific article

GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice

scientific article

Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors

scientific article

Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance

scientific article

Lack of tolerance to the anxiolytic effect of diazepam and pentobarbital following chronic administration in perinatally undernourished rats ⬇️

scientific article published on June 1, 1998

Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.

scientific article

Mutation in neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes blocks ethanol action.

scientific article published in September 2003

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

scientific article

Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice

scientific article

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

scientific article published on 24 July 2017

Phosphatidylserine increases hippocampal synaptic efficacy.

scientific article published in January 1993

Reduced tolerance to certain pharmacological effects of ethanol after chronic administration in perinatally undernourished rats

scientific article published on 01 August 1997

Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors.

scientific article published in October 2003

The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.

scientific article published on 4 November 2005

The molecular pharmacology of volatile anesthetics

scientific article

List of works by Cecilia M. Borghese

A transmembrane site determines sensitivity of neuronal nicotinic acetylcholine receptors to general anesthetics.

An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice

Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels

GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice

Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors

Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance

Lack of tolerance to the anxiolytic effect of diazepam and pentobarbital following chronic administration in perinatally undernourished rats ⬇️

Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.

Mutation in neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes blocks ethanol action.

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

Phosphatidylserine increases hippocampal synaptic efficacy.

Reduced tolerance to certain pharmacological effects of ethanol after chronic administration in perinatally undernourished rats

Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors.

The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.

The molecular pharmacology of volatile anesthetics