List of works - Tom Maniatis

A dimer-specific function of the transcription factor NFATp

scholarly article

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model

scientific article

A prion-like trigger of antiviral signaling

scientific article published on August 2011

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

scientific article published on January 2013

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice

scientific article

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

scientific article

An Atomic Model of the Interferon-β Enhanceosome

scientific article

Astrocytes in neurodegenerative disease

scientific article published on 15 April 2015

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

scientific article

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

scientific article published on August 2015

CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice

scientific article

Cardiac glycosides are potent inhibitors of interferon-β gene expression

scientific article published on 14 November 2010

Caspase-mediated processing of the Drosophila NF-kappaB factor Relish

scientific article

Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons

Clustered protocadherins

scientific article

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

scientific article published on June 2013

Connecting mitochondria and innate immunity

scientific article

Crystal structure and mechanism of activation of TANK-binding kinase 1

scientific article

Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer

scientific article published on 28 October 2004

Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site

scientific article

Detection of single base substitutions in total genomic DNA

scientific article published in Nature

Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.

scientific article

Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine

scientific article published in Nature

Endocytic pathway is required for Drosophila Toll innate immune signaling

scientific article

Erratum: Corrigendum: Structure-based prediction of protein–protein interactions on a genome-wide scale

scientific article published in Nature

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

scientific article published on 19 February 2015

ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data

scientific article

FUS-SMN protein interactions link the motor neuron diseases ALS and SMA

scientific article

Functional significance of isoform diversification in the protocadherin gamma gene cluster

scientific article

Histone and DNA Modifications as Regulators of Neuronal Development and Function

scientific article published in July 2016

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

scientific article

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

scientific article (publication date: May 2003)

Identification of long-range regulatory elements in the protocadherin-alpha gene cluster

scholarly article

Immune Activation of NF-κB and JNK Requires Drosophila TAK1 ⬇️

scientific article published on September 30, 2003

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch

scientific article published on 25 May 2007

Intricate interplay between astrocytes and motor neurons in ALS.

scientific article published on 6 February 2013

IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses

scientific article published on 14 December 2011

Molecular and functional interaction between protocadherin-γC5 and GABAA receptors

scientific article

Molecular logic of neuronal self-recognition through protocadherin domain interactions

scientific article

Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly

scientific article published on April 2017

Multilevel regulation of gene expression by microRNAs

scientific article published on March 2008

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

scientific article

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

scientific article published on 26 March 2012

Negative regulation of interferon-β gene expression during acute and persistent virus infections

scientific article

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

scientific article

On the road from classical to modern molecular biology

scientific article

Parallel pathways of virus recognition

scientific article

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice

scientific article published on April 2017

Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret

scientific article

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

scientific article published on 09 May 2016

Proteolytic processing of protocadherin proteins requires endocytosis ⬇️

scientific article published on September 27, 2010

Protocadherin cis-dimer architecture and recognition unit diversity

scientific article published on 30 October 2017

Protocadherins mediate dendritic self-avoidance in the mammalian nervous system

scientific article

Regulatory elements required for the activation and repression of the protocadherin-alpha gene cluster

scientific article

Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-α gene expression

scientific article

Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers

scientific article

Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins

scientific article

Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development

scientific article published on May 2017

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

scientific article

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

scientific article

Stochastic expression of the interferon-β gene

scientific article

Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins

scientific journal article

Structural origins of clustered protocadherin-mediated neuronal barcoding

scientific article published on 22 July 2017

Structure-based prediction of protein–protein interactions on a genome-wide scale

scientific article (publication date: 30 September 2012)

Systems-level analyses identify extensive coupling among gene expression machines

scientific article published on 17 January 2006

The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing

scientific article

The regulated expression of β-globin genes introduced into mouse erythroleukemia cells

article

The role of ubiquitination in Drosophila innate immunity.

scientific article published on 4 August 2005

The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene

scientific article

Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products

article

Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time

scientific article published on 11 July 2013

Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly

scientific article published on 01 October 2018

[31] Detection and localization of single base changes by denaturing gradient gel electrophoresis

article by Richard M. Myers et al published 1987 in Methods in Enzymology

hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function

scientific journal article

List of works by Tom Maniatis

A dimer-specific function of the transcription factor NFATp

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model

A prion-like trigger of antiviral signaling

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

An Atomic Model of the Interferon-β Enhanceosome

Astrocytes in neurodegenerative disease

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice

Cardiac glycosides are potent inhibitors of interferon-β gene expression

Caspase-mediated processing of the Drosophila NF-kappaB factor Relish

Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons

Clustered protocadherins

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

Connecting mitochondria and innate immunity

Crystal structure and mechanism of activation of TANK-binding kinase 1

Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer

Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site

Detection of single base substitutions in total genomic DNA

Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.

Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine

Endocytic pathway is required for Drosophila Toll innate immune signaling

Erratum: Corrigendum: Structure-based prediction of protein–protein interactions on a genome-wide scale

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data

FUS-SMN protein interactions link the motor neuron diseases ALS and SMA

Functional significance of isoform diversification in the protocadherin gamma gene cluster

Histone and DNA Modifications as Regulators of Neuronal Development and Function

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

Identification of long-range regulatory elements in the protocadherin-alpha gene cluster

Immune Activation of NF-κB and JNK Requires Drosophila TAK1 ⬇️

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch

Intricate interplay between astrocytes and motor neurons in ALS.

IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses

Molecular and functional interaction between protocadherin-γC5 and GABAA receptors

Molecular logic of neuronal self-recognition through protocadherin domain interactions

Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly

Multilevel regulation of gene expression by microRNAs

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

Negative regulation of interferon-β gene expression during acute and persistent virus infections

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

On the road from classical to modern molecular biology

Parallel pathways of virus recognition

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice

Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

Proteolytic processing of protocadherin proteins requires endocytosis ⬇️

Protocadherin cis-dimer architecture and recognition unit diversity

Protocadherins mediate dendritic self-avoidance in the mammalian nervous system

Regulatory elements required for the activation and repression of the protocadherin-alpha gene cluster

Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-α gene expression

Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers

Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins

Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

Stochastic expression of the interferon-β gene

Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins

Structural origins of clustered protocadherin-mediated neuronal barcoding

Structure-based prediction of protein–protein interactions on a genome-wide scale

Systems-level analyses identify extensive coupling among gene expression machines

The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing

The regulated expression of β-globin genes introduced into mouse erythroleukemia cells

The role of ubiquitination in Drosophila innate immunity.

The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene

Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products

Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time

Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly

[31] Detection and localization of single base changes by denaturing gradient gel electrophoresis

hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function