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List of works by Leo Swadling

A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection

article

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

scientific article published on November 2014

Adenoviral Vector Vaccination Induces a Conserved Program of CD8(+) T Cell Memory Differentiation in Mouse and Man.

scientific article published on 11 November 2015

Association Between Impaired Vα7.2+CD161++CD8+ (MAIT) and Vα7.2+CD161-CD8+ T-Cell Populations and Gut Dysbiosis in Chronically HIV- and/or HCV-Infected Patients

scientific article published on 28 August 2019

Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

scientific article published on 15 December 2020

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

scientific article published in 2021

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.

scientific article published on 23 October 2014

CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

scientific article

Characterising HCV specific CD4+ T-cells following viral-vectored vaccination, directly acting anti-virals and spontaneous viral cure

scientific article published on 03 February 2020

Characterization of the Specificity, Functionality, and Durability of Host T-Cell Responses Against the Full-Length Hepatitis E Virus

scientific article published on 15 September 2016

Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans

scientific article published on 16 October 2015

Circulating and intrahepatic antiviral B cells are defective in hepatitis B

scientific article published on 09 August 2018

Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes

scientific article published on 30 October 2014

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

scientific article published on 01 December 2020

Ever closer to a prophylactic vaccine for HCV.

scientific article published on 07 May 2013

Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection

scientific article published on 2 August 2016

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

scientific article published on 01 January 2020

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

scientific article published on 19 June 2024

IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction.

scientific article published on 9 May 2018

IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.

scientific article

Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

scientific article published on 14 June 2022

Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101.

scientific article published on 11 March 2017

Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing

scientific article published on 24 August 2017

Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines.

scientific article

Isolation of human intrahepatic leukocytes for phenotypic and functional characterization by flow cytometry

scientific article published in 2022

Liver-resident CD8+ T cells: learning lessons from the local experts

scientific article published on 28 February 2020

Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes

scientific article published on 01 September 2020

MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans

scientific article published on 01 June 2020

Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.

scientific article published on January 2012

Optimising T cell (re)boosting strategies for adenoviral and modified vaccinia Ankara vaccine regimens in humans

scientific article published on 12 October 2020

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

scientific article published in January 2022

Successful direct-acting antiviral therapy in HIV/HCV co-infected patients fails to restore circulating mucosal-associated invariant T cells

scientific article published on 14 May 2019

T cells in COVID-19 - united in diversity

scientific article published on 07 September 2020

Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

scientific article published on September 2017

The Liver as an Immunological Barrier Redefined by Single Cell Analysis

scientific article published on 16 March 2020

The Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways

scientific article published on 10 July 2020

Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS

Viral vectored hepatitis C virus vaccines generate pan-genotypic T cell responses to conserved subdominant epitopes

scientific article published on 09 June 2020

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