Search filters

List of works by Helena Earl

A Bayesian adaptive design for biomarker trials with linked treatments

scientific article published on 11 August 2015

A Comprehensive Single Institutional Review of 2 Years in a Designated Fast-Track Sarcoma Diagnostic Clinic Linked with a Sarcoma Specialist Advisory Group: Meeting the Target but Failing the Task?

scientific article published on 02 June 2016

A cancer research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen.

scientific article

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

scientific article published on June 2016

A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer.

scientific article published on October 2003

A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities

scientific article

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

scientific article published on 16 January 2020

A phase I trial to assess the value of recombinant human granulocyte colony stimulating factor (r-MetHuG-CSF, filgrastim) in accelerating the dose rate of chemotherapy for intermediate and high-grade non-Hodgkin's lymphoma (NHL) ⬇️

scientific article published on December 1, 1996

A phase II study of Tomudex in relapsed epithelial ovarian cancer

scientific article published on 01 September 1995

A prospective randomized trial to evaluate different oral dose regimens of medroxyprogesterone acetate in women with advanced breast cancer

scientific article published on 01 January 1995

A questionnaire survey of stress and bullying in doctors undertaking research

scientific article

A randomised phase III cross-over study of tamoxifen versus megestrol acetate in advanced and recurrent breast cancer

scientific article published on 01 October 1996

A randomised, placebo-controlled trial of weekly paclitaxel and saracatinib (AZD0530) in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer†.

scientific article published on 28 July 2014

A randomized phase-II study of BB-10010 (macrophage inflammatory protein- 1alpha) in patients with advanced breast cancer receiving 5-fluorouracil, adriamycin, and cyclophosphamide chemotherapy

scientific article published on 01 September 1998

A randomized trial of carboplatin versus iproplatin in untreated advanced ovarian cancer.

scientific article published in July 1991

A study to evaluate the use of CA125 in ovarian cancer follow-up: A change in practice led by patient preference

scientific article published on 30 January 2006

A survey of breast cancer patients' views on entry into several clinical studies

scientific article published on 01 March 2004

Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer in the randomised UK TACT2 trial (CRUK/05/19): a multicentre, phase 3, open-label, randomised, c ⬇️

article

Accuracy of unidimensional and volumetric ultrasound measurements in predicting good pathological response to neoadjuvant chemotherapy in breast cancer patients

scientific article published on 25 March 2011

Addition of gemcitabine to paclitaxel, epirubicin, and cyclophosphamide adjuvant chemotherapy for women with early-stage breast cancer (tAnGo): final 10-year follow-up of an open-label, randomised, phase 3 trial.

scientific article published on 4 May 2017

Adjuvant trastuzumab duration trials in HER2 positive breast cancer - what results would be practice-changing? Persephone investigator questionnaire prior to primary endpoint results.

scientific article published on 5 April 2018

Adjuvant treatment with tamoxifen. Recruitment into studies assessing optimum duration of treatment must continue.

scientific article published in April 1996

Adriamycin and mitomycin C as initial chemotherapy for advanced breast cancer

scientific article published on 01 May 1984

American Society for Clinical Oncology 39th Annual Meeting, Chicago, Illinois, USA, 31 May to 3 June 2003: breast cancer neoadjuvant and adjuvant chemotherapy--prognostic and predictive markers

scientific article

An Association of Cancer Physicians' strategy for improving services and outcomes for cancer patients ⬇️

scientific article (publication date: 2016)

An EORTC phase II study of mitoxantrone in solid tumors and lymphomas

scientific article published on 01 November 1984

Anthracyclines and taxanes in the neo/adjuvant treatment of breast cancer: does the sequence matter?

scientific article published on 13 March 2014

Assessment of five serum marker assays in patients with advanced breast cancer treated with medroxyprogesterone acetate

scientific article published on 01 September 1995

Barriers to effective communication across the primary/secondary interface: examples from the ovarian cancer patient journey (a qualitative study).

scientific article

Blood transfusion requirements for patients with sarcomas undergoing combined radio- and chemotherapy.

scientific article published on January 2005

Body mass index and breast cancer survival: a Mendelian randomization analysis

scientific article published in December 2017

Book Reviews

CYP2D6 gene variants and their association with breast cancer susceptibility

scientific article

CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen

scientific article

Can breast MRI help in the management of women with breast cancer treated by neoadjuvant chemotherapy?

scientific article published on April 2004

Central pathology review with two-stage quality assurance for pathological response after neoadjuvant chemotherapy in the ARTemis Trial

scientific article published on 26 May 2017

Chemotherapy for ovarian cancer--a consensus statement on standard practice. ⬇️

scientific article published on December 1998

Chemotherapy of malignant fibrous histiocytoma of bone

scientific article published on 01 May 1993

Clinical trial designs for rare diseases: studies developed and discussed by the International Rare Cancers Initiative ⬇️

scientific article

Common germline polymorphisms associated with breast cancer-specific survival

scientific article published on 22 April 2015

Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others

scientific article published on 29 April 2016

Complete resolution of metastatic breast cancer by withdrawal of hormone replacement therapy

scientific article published on 01 January 2001

Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer.

scientific article published on 16 February 2016

Computerised tomographic (CT) abdominal scanning in Hodgkin's disease

scientific article published on 01 March 1980

Conformal radiotherapy facilitates the delivery of concurrent chemotherapy and radiotherapy: a case of primitive neuroectodermal tumour of the chest wall.

scientific article

Desmoplastic small round cell tumour: characteristics and prognostic factors of 41 patients and review of the literature

scientific article

Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer

scientific article published on 24 July 2019

Dynamic contrast-enhanced MRI in ovarian cancer: Initial experience at 3 tesla in primary and metastatic disease.

scientific article

Effect of Simultaneous Water Deficit Stress and Meloidogyne incognita Infection on Cotton Yield and Fiber Quality

scientific article published on June 2014

Effectiveness of high-dose combination chemotherapy and autologous bone marrow transplantation for patients with non-Hodgkin's lymphomas who are still responsive to conventional-dose therapy

scientific article published on 01 November 1989

Effects of the addition of gemcitabine, and paclitaxel-first sequencing, in neoadjuvant sequential epirubicin, cyclophosphamide, and paclitaxel for women with high-risk early breast cancer (Neo-tAnGo): an open-label, 2×2 factorial randomised phase 3

scientific article

Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): an open-label, randomised, phase 3 trial

scientific article published on 11 May 2015

Epirubicin and cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy for early breast cancer

scientific article published in November 2006

Epirubicin as adjuvant therapy in breast cancer.

scientific article published on April 2004

Epirubicin, Cisplatin, and Capecitabine for Primary Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer: Results of a Retrospective, Single-Institution Study

scientific article published on July 2015

Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

scientific article published on 6 June 2016

Etoposide protein binding in cancer patients

scientific article published on 01 January 1995

Evaluation of glomerular filtration rate estimation by Cockcroft-Gault, Jelliffe, Wright and Modification of Diet in Renal Disease (MDRD) formulae in oncology patients.

scientific article published on 21 November 2011

Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

scientific article

Five-year outcome for women randomised in a phase III trial comparing doxorubicin and cyclophosphamide with doxorubicin and docetaxel as primary medical therapy in early breast cancer: an Anglo-Celtic Cooperative Oncology Group study.

scientific article published on 18 June 2010

Genome-wide association study of germline variants and breast cancer-specific mortality

scientific article published on 21 February 2019

Geriatric manic delirium with no previous history of mania

scientific article published on 01 January 2011

HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data

scientific article

ICON3 and chemotherapy for ovarian cancer

article published in 2002

Identification of novel genetic markers of breast cancer survival

scientific article published on 18 April 2015

Identification of patients at high risk of chemotherapy-induced toxicity in small-cell lung cancer

scientific article published on 01 January 1988

Image-guided biopsy in patients with suspected ovarian carcinoma: a safe and effective technique?

scientific article published on 15 August 2008

Intensive chemotherapy and thoracic irradiation as induction treatment in limited-stage small-cell lung cancer

scientific article published on 01 January 1988

Intensive chemotherapy with autologous bone marrow transplantation for small-cell lung cancer

scientific article published on 01 January 1989

Intensive cisplatin/oral etoposide for epithelial ovarian cancer: the Cambridge Gynae-Oncology Centre experience: too toxic for relapse?

scientific article published on 16 November 2015

Intensive weekly chemotherapy for good-prognosis patients with small-cell lung cancer

scientific article published on 01 February 1991

Laboratory handling and histology reporting of breast specimens from patients who have received neoadjuvant chemotherapy

scientific article published on March 2007

Long-term neurotoxicity of chemotherapy in adolescents and young adults treated for bone and soft tissue sarcomas.

scientific article published on January 1998

Major milestones in translational oncology.

scientific article published on 28 July 2016

Mammary gland 1,25-dihydroxyvitamin D3 receptor content during pregnancy and lactation

scientific article published on 01 November 1988

Management of breast cancer. Refer women to multidisciplinary breast clinics

scientific article published on March 1994

Melanoma cell lines express VEGF receptor KDR and respond to exogenously added VEGF

scientific article published on 01 December 1995

Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T.

scientific article published in October 2009

Multi-omic machine learning predictor of breast cancer therapy response

scientific article published on 07 December 2021

Multicenter Validation of the CamGFR Model for Estimated Glomerular Filtration Rate

scientific article published on 19 September 2019

Multidisciplinary management of malignant ovarian germ cell tumours.

scientific article published on 25 February 2011

Neoadjuvant trials in early breast cancer: pathological response at surgery and correlation to longer term outcomes - what does it all mean?

scientific article published on 22 September 2015

New Model for Estimating Glomerular Filtration Rate in Patients With Cancer

scientific article published on 7 July 2017

New paradigms for BRCA1/BRCA2 testing in women with ovarian cancer: results of the Genetic Testing in Epithelial Ovarian Cancer (GTEOC) study ⬇️

scientific article published on 12 May 2016

Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?

scientific article published in July 2009

Norethisterone acetate in the treatment of advanced breast cancer

scientific article published on 01 June 1984

Optimising patient recall of adverse events over prolonged time periods.

scientific article

Paclitaxel (Taxol) in relapsed and refractory ovarian cancer: the UK and Eire experience. ⬇️

scientific article

Patients at risk of chemotherapy-associated toxicity in small cell lung cancer

scientific article

Percutaneous nephrostomies in women with cervical cancer

scientific article published on 01 March 1993

Practicalities of using an adaptive design for decision making within the optima trial: optimal personalized treatment of early breast cancer using multi-parameter tests.

scientific article published on 16 November 2015

Predicting Anthracycline Benefit: TOP2A and CEP17-Not Only but Also

scientific article published on 20 April 2015

Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601).

scientific article published on 13 January 2010

Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the NEAT/BR9601 trial

scientific article published on 18 April 2013

Prognostic factors in patients with small-cell lung cancer: preliminary results from a large randomised study

scientific article published on 01 January 1988

Prolonged response of relapsed high grade serous ovarian carcinoma to the oral angiokinase inhibitor nintedanib in a patient with a germline BRCA1 mutation

scientific article

Prolonged response of relapsed high grade serous ovarian carcinoma to the oral angiokinase inhibitor nintedanib in a patient with a germline BRCA1 mutation.

scientific article published on 17 October 2012

Psychological predictors of attendance at annual breast screening examinations ⬇️

scientific article published on June 1, 1998

Quantitative analysis of vascular endothelial growth factor expression in chronic lymphocytic leukaemia

scientific article published on 01 January 1996

Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer.

scientific article

Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel--response

scientific article published on 01 July 2015

Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel

scientific article published on 5 March 2014

Reporting of adjuvant breast cancer trials: when is the right time?

scientific article published on 21 November 2011

Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping

scientific article

Selecting breast cancer patients for chemotherapy: the opening of the UK OPTIMA trial.

scientific article published on 23 December 2012

Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial

scientific article published on May 2009

Six versus 12 months' adjuvant trastuzumab in patients with HER2-positive early breast cancer: the PERSEPHONE non-inferiority RCT

scientific article published on 01 August 2020

Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer

scientific article published on 19 April 2019

Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis

scientific article

Spotlight on landmark oncology trials: the latest evidence and novel trial designs.

scientific article published on 2 June 2017

T-cell lymphomas in adults: a clinicopathological study of eighteen cases

scientific article published on 01 June 1987

Tests for detecting recurrent disease in the follow-up of patients with breast cancer

scientific article published on 01 July 1988

The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study ⬇️

scientific article

The challenges of using radiological ‘tumour response' as an outcome: lessons learned from neo-tango and artemis, two neo-adjuvant chemotherapy breast cancer trials.

scientific article published on 29 November 2013

The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel

scientific article

The optimal duration of adjuvant tamoxifen treatment for breast cancer remains uncertain: randomize into aTTom

scientific article published on 01 January 1997

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

scientific article

Trabectedin for advanced soft tissue sarcomas: a single institution experience.

scientific article

Trastuzumab-associated cardiac events in the Persephone trial

scientific article published on 22 November 2016

Triple drug therapy of Herpes zoster infection occurring in patients with reticulo-endothelial neoplasia--a preliminary study

scientific article published on 01 November 1980

Urinary-derived monocyte-colony stimulating factor (P-100) following treatment with carboplatin and etoposide in small cell lung cancer (SCLC)

scientific article published on 01 December 1993

Value of Information Analysis of Multiparameter Tests for Chemotherapy in Early Breast Cancer: The OPTIMA Prelim Trial ⬇️

scientific article published on 11 July 2017

Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal carcinoma treatment (ICON8): primary progression free survival analysis results from a GCIG phase 3 randomised controlled trial

scientific article published on 29 November 2019

Whither high-dose chemotherapy in breast cancer?

scientific article

Paulina is supported by:

About Paulina

Help