List of works - Katerina Akassoglou

A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice

scientific article published on 01 March 1999

Acute vascular disruption and aquaporin 4 loss after stroke

scientific article

Alzheimer disease makes new blood contacts

scientific article published on May 2017

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice

scientific article published in January 1997

Author Correction: The immunology of blood: connecting the dots at the neurovascular interface

scientific article published on 07 July 2020

Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

scientific article published on 13 July 2020

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

scientific article

Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration

scholarly article

Breaking boundaries-coagulation and fibrinolysis at the neurovascular interface

scientific article

Characterization of agonist-induced vasoconstriction in mouse pulmonary artery.

scientific article published on 2 November 2007

Chronic optical access through a polished and reinforced thinned skull

scientific article

Coagulation takes center stage in inflammation

scientific article

Contributors

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

article published in the Proceedings of the National Academy of Sciences of the United States of America

Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.

scientific article published on April 1996

Early detection of thrombin activity in neuroinflammatory disease

scientific article

Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice.

scholarly article

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

scientific article

Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.

scientific article published on 8 May 2019

Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis.

scientific article

Fibrin drives thromboinflammation and neuropathology in COVID-19

scientific article published on 28 August 2024

Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation

scientific article published on 01 March 2002

Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice

scientific article published on 01 March 2003

Fibrin mechanisms and functions in nervous system pathology

scientific article published on June 2004

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

scientific article published on 15 October 2018

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

scientific article published on 19 October 2017

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model

scientific article published on 05 February 2019

Fibrinogen as a key regulator of inflammation in disease

scientific article published on 31 October 2011

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.

scientific article published on 5 April 2018

Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling

scientific article published on 31 January 2020

Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor

scholarly article

Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis

scientific article published on January 2007

Fibrinogen signal transduction in the nervous system.

scientific article

Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage

scientific article

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.

scientific article

Finding the 'ubiquitous' threads in infection and autoimmune neuroinflammation

scientific article published on December 2016

Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy.

scientific article published on January 2016

Glial expression of tumor necrosis factor in transgenic animals: how do these models reflect the "normal situation"?

scientific article

Glucose homeostasis and p75NTR: the sweet side of neurotrophin receptor signaling

scientific article published on 16 August 2012

Hepatic stellate cells and astrocytes: Stars of scar formation and tissue repair

scientific article

Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease(,.)

scientific article published in March 2015

Imaging the dynamic interactions between immune cells and the neurovascular interface in the spinal cord

scientific article published on 28 August 2019

In Vivo Imaging of CNS Injury and Disease

scientific article published in November 2017

In vivo imaging of the mouse spinal cord using two-photon microscopy

scientific article

In vivo imaging of the neurovascular unit in CNS disease.

scientific article

Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival.

scientific article published in April 2006

Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha transgenic mice, one characterized by neurological disorders, the other phenotypically normal

scientific article published in September 1999

Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis

scientific article published on 19 March 2009

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

scientific article published on 28 December 2018

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.

scientific article

Microglial G<sub>i</sub>-dependent dynamics regulate brain network hyperexcitability

scientific article published on 14 December 2020

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

scientific article

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

scientific article published on 15 March 2017

Mutant huntingtin impairs immune cell migration in Huntington disease.

scientific article

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

scientific article published on 23 April 2008

Nerve growth factor-independent neuronal survival: a role for NO donors

scientific article

Nervous system pathology: the fibrin perspective

scientific article

Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain.

scientific article published in June 1996

Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium

scientific article published on 22 February 2016

Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions

scientific article

Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.

scientific article published on September 1998

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

scientific article published on 10 October 2016

Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

scientific article published on November 2011

P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation.

scientific article published on 5 July 2006

P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation.

scholarly article

Pericytes: The Brain's Very First Responders?

scientific article published on 01 October 2018

Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis

scientific article published on 01 October 2001

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease

scientific article

Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation

scientific article published on February 2012

Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain

scientific article published on 13 December 2012

Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors.

scientific article published on November 2007

Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR

scientific article published on 01 March 2007

Resolving postoperative neuroinflammation and cognitive decline.

scientific article published in December 2011

Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1

scientific article published on 01 August 2018

SIRT1 deacetylates RORγt and enhances Th17 cell generation

scientific article published on 27 April 2015

SIRT1 deacetylates RORγt and enhances Th17 cell generation

scientific article published on 18 May 2015

Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination

scientific article

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

scientific article

Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy.

scientific article

Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice

scientific article

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor

scientific article

Systemic inflammation regulates microglial responses to tissue damage in vivo

scientific article

TNF-alpha transgenic and knockout models of CNS inflammation and degeneration

scientific article published on February 1997

TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease

scientific article

The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

scientific article

The immunology of blood: connecting the dots at the neurovascular interface

scientific article published on 01 July 2020

Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury.

scientific article

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

scientific article published on 13 April 2020

Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.

scientific article

Transgenic models of TNF induced demyelination

scientific article

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.

scientific article published on 2 December 2012

p75 (NTR) and hypoxia: a breath of fresh air in neurotrophin receptor signaling

scientific article published on 01 March 2012

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

scientific article published on 30 December 2015

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks

scientific article

p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction.

scientific article published on 08 August 2008

p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity

scientific journal article

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway

scientific article

List of works by Katerina Akassoglou

A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice

A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice

Acute vascular disruption and aquaporin 4 loss after stroke

Alzheimer disease makes new blood contacts

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice

Author Correction: The immunology of blood: connecting the dots at the neurovascular interface

Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration

Breaking boundaries-coagulation and fibrinolysis at the neurovascular interface

Characterization of agonist-induced vasoconstriction in mouse pulmonary artery.

Chronic optical access through a polished and reinforced thinned skull

Coagulation takes center stage in inflammation

Contributors

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.

Early detection of thrombin activity in neuroinflammatory disease

Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice.

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.

Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis.

Fibrin drives thromboinflammation and neuropathology in COVID-19

Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation

Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice

Fibrin mechanisms and functions in nervous system pathology

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model

Fibrinogen as a key regulator of inflammation in disease

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.

Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling

Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor

Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis

Fibrinogen signal transduction in the nervous system.

Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.

Finding the 'ubiquitous' threads in infection and autoimmune neuroinflammation

Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy.

Glial expression of tumor necrosis factor in transgenic animals: how do these models reflect the "normal situation"?

Glucose homeostasis and p75NTR: the sweet side of neurotrophin receptor signaling

Hepatic stellate cells and astrocytes: Stars of scar formation and tissue repair

Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease(,.)

Imaging the dynamic interactions between immune cells and the neurovascular interface in the spinal cord

In Vivo Imaging of CNS Injury and Disease

In vivo imaging of the mouse spinal cord using two-photon microscopy

In vivo imaging of the neurovascular unit in CNS disease.

Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival.

Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha transgenic mice, one characterized by neurological disorders, the other phenotypically normal

Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.

Microglial G<sub>i</sub>-dependent dynamics regulate brain network hyperexcitability

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

Mutant huntingtin impairs immune cell migration in Huntington disease.

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

Nerve growth factor-independent neuronal survival: a role for NO donors

Nervous system pathology: the fibrin perspective

Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain.

Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium

Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions

Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation.

P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation.

Pericytes: The Brain's Very First Responders?

Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease

Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation

Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain

Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors.

Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR

Resolving postoperative neuroinflammation and cognitive decline.

Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1

SIRT1 deacetylates RORγt and enhances Th17 cell generation

SIRT1 deacetylates RORγt and enhances Th17 cell generation

Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha