List of works - Markus Sack

A carcinoembryonic antigen-specific diabody produced in tobacco.

scientific article published on 14 January 2002

Affinity purification of a framework 1 engineered mouse/human chimeric IgA2 antibody from tobacco.

scientific article published on 19 July 2011

Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10

scientific article

Antibodies from plants for bionanomaterials

scientific article published on 27 March 2017

Application of a Scalable Plant Transient Gene Expression Platform for Malaria Vaccine Development

scientific article

CRISPR/Cas9-mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β-1,2-xylose and core α-1,3-fucose.

scientific article published on 11 August 2018

Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies

scholarly article

Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K521 Polymorphism.

scientific article published on 28 December 2016

Characterization of new anti-IL-6 antibodies revealed high potency candidates for intracellular cytokine detection and specific targeting of IL-6 receptor binding sites

scientific article published on 01 June 2018

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.

scholarly article

Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V

scholarly article

ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.

scientific article

Expression and characterization of bispecific single-chain Fv fragments produced in transgenic plants

scientific article published on 01 June 1999

From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants

scientific article published on 27 July 2015

Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures.

scientific article published on 27 February 2007

Generation and characterization of a recombinant antibody fragment that binds to the coat protein of grapevine leafroll-associated virus 3.

scientific article

Glyco-Engineering of Plant-Based Expression Systems

scientific article published on 02 August 2018

Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein

scientific article published on 13 March 2015

Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium

scientific article published on 30 September 2004

Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody

scientific article published on 13 October 2009

Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture.

scientific article

Overcoming low yields of plant-made antibodies by a protein engineering approach

scientific article published on 3 December 2015

Phage-display derived single-chain fragment variable (scFv) antibodies recognizing conformational epitopes of Escherichia coli heat-labile enterotoxin B-subunit.

scientific article

Pharmacokinetics and immunogenicity of broadly neutralizing HIV monoclonal antibodies in macaques

scientific article

Plant cell packs: a scalable platform for recombinant protein production and metabolic engineering

scientific article published on 14 February 2019

Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins

scientific article

Plantibodies: applications, advantages and bottlenecks

scientific article

Practical considerations for pharmaceutical antibody production in different crop systems

Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques

scientific article

Putting the Spotlight Back on Plant Suspension Cultures

scientific article

Rapid high-level production of functional HIV broadly neutralizing monoclonal antibodies in transient plant expression systems

scientific article

Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody

scientific article

Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-alpha(1,3)-fucose residues.

scientific article published on July 2004

Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans.

scientific article published on 3 November 2007

Recombinant soluble human Fcgamma receptor I with picomolar affinity for immunoglobulin G.

scientific article published on 2 November 2005

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.

scientific article

Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies

scientific article published on 01 January 1999

SNAP-Tag Technology: A Useful Tool To Determine Affinity Constants and Other Functional Parameters of Novel Antibody Fragments.

scientific article published on 8 July 2016

The in-line measurement of plant cell biomass using radio frequency impedance spectroscopy as a component of process analytical technology.

scientific article published on 23 August 2013

The increasing value of plant-made proteins.

scientific article published on 15 January 2015

Towards molecular farming in the future: transient protein expression in plants.

scientific article

Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

scientific article published on 13 October 2015

Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves

scientific article published on September 1999

List of works by Markus Sack

A carcinoembryonic antigen-specific diabody produced in tobacco.

Affinity purification of a framework 1 engineered mouse/human chimeric IgA2 antibody from tobacco.

Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10

Antibodies from plants for bionanomaterials

Application of a Scalable Plant Transient Gene Expression Platform for Malaria Vaccine Development

CRISPR/Cas9-mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β-1,2-xylose and core α-1,3-fucose.

Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies

Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K521 Polymorphism.

Characterization of new anti-IL-6 antibodies revealed high potency candidates for intracellular cytokine detection and specific targeting of IL-6 receptor binding sites

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.

Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V

ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.

Expression and characterization of bispecific single-chain Fv fragments produced in transgenic plants

From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants

Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures.

Generation and characterization of a recombinant antibody fragment that binds to the coat protein of grapevine leafroll-associated virus 3.

Glyco-Engineering of Plant-Based Expression Systems

Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein

Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium

Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody

Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture.

Overcoming low yields of plant-made antibodies by a protein engineering approach

Phage-display derived single-chain fragment variable (scFv) antibodies recognizing conformational epitopes of Escherichia coli heat-labile enterotoxin B-subunit.

Pharmacokinetics and immunogenicity of broadly neutralizing HIV monoclonal antibodies in macaques

Plant cell packs: a scalable platform for recombinant protein production and metabolic engineering

Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins

Plantibodies: applications, advantages and bottlenecks

Practical considerations for pharmaceutical antibody production in different crop systems

Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques

Putting the Spotlight Back on Plant Suspension Cultures

Rapid high-level production of functional HIV broadly neutralizing monoclonal antibodies in transient plant expression systems

Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody

Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-alpha(1,3)-fucose residues.

Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans.

Recombinant soluble human Fcgamma receptor I with picomolar affinity for immunoglobulin G.

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.

Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies

SNAP-Tag Technology: A Useful Tool To Determine Affinity Constants and Other Functional Parameters of Novel Antibody Fragments.

The in-line measurement of plant cell biomass using radio frequency impedance spectroscopy as a component of process analytical technology.

The increasing value of plant-made proteins.

Towards molecular farming in the future: transient protein expression in plants.

Transgenic Production of an Anti HIV Antibody in the Barley Endosperm

Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves