List of works by David Curtis

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to DNA loci D5S6, D5S39, and D5S76 ⬇️

scientific article published on November 1, 1991

A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia

scientific article

A genome-wide family-based linkage study of coeliac disease

scientific article published on 01 November 2000

A linkage study of affective disorder with DNA markers for the ABO-AK1-ORM linkage group near the dopamine beta hydroxylase gene

article

A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families

scientific article published on 01 October 1996

A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees

article

A note on the calculation of empirical P values from Monte Carlo procedures.

scientific article published in August 2002

A novel polymorphism in exon 11 of the WKL1 gene, shows no association with schizophrenia

scientific article (publication date: August 2002)

A pedigree-based linkage study of coeliac disease: failure to replicate previous positive findings

scientific article published on 01 January 1998

A polygenic resilience score moderates the genetic risk for schizophrenia

scientific article published on 06 September 2019

A possible role for sarcosine in the management of schizophrenia

scientific article published on 01 December 2019

A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies

scientific article

A procedure for combining two-point lod scores into a summary multipoint map.

scientific article published in May 1993

A program for the monte carlo evaluation of significance of the extended transmission/disequilibrium test.

scientific article published in May 1999

A quick and simple method for detecting subjects with abnormal genetic background in case-control samples

scientific article published on 01 May 2002

A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia

scientific article

Allelic association studies of genome wide association data can reveal errors in marker position assignments

scientific article

Allelic association, DNA resequencing and copy number variation at the metabotropic glutamate receptor GRM7 gene locus in bipolar disorder

scientific article

Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians

scientific article published on 21 July 1997

An extended transmission/disequilibrium test (TDT) for multi-allele marker loci.

scientific article published on July 1995

Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data.

scientific article

Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters

article

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Another procedure for the preliminary ordering of loci based on two point lod scores

scientific article published on 01 January 1994

Application of Logistic Regression to Case-Control Association Studies Involving Two Causative Loci

scientific article published on 18 April 2005

Approaches to the detection of recessive effects using next generation sequencing data from outbred populations

scientific article

Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetes.

scientific article published in July 2003

Assessing the contribution family data can make to case-control studies of rare variants

scientific article

Association study of rare nonsynonymous variants of FTO in bipolar disorder

scientific article published on June 2016

Association study of schizophrenia with variants in miR-137 binding sites

Association study of schizophrenia with variants in miR-137 binding sites.

scientific article published on 17 November 2017

Audit of psychiatric discharge summaries: completing the cycle

CLUMPHAP: a simple tool for performing haplotype-based association analysis.

scientific article published in September 2008

CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families.

scientific article published in January 2002

Cardiovascular disease risk

scientific article published on 01 April 1996

Case report: rapidly fatal bowel ischaemia on clozapine treatment

scientific article

Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes

scientific article

Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders

scientific article published on 12 February 2008

Chromosome 22 markers demonstrate transmission disequilibrium with schizophrenia

article

Chromosome markers in Tourette's syndrome

scientific article published in January 1991

Clinical relevance of genome-wide polygenic score may be less than claimed

scientific article published on 25 March 2019

Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1

scientific article

Coeliac disease and Down syndrome: associations not due to genetic linkage on chromosome 21

scientific article published on 01 February 2000

Coeliac disease: follow-up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11

scientific article published on 01 July 2001

Coeliac disease: investigation of proposed causal variants in the CTLA4 gene region

article

Cognitive therapy is no better than supportive counselling in schizophrenia.

scientific article published on September 1999

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

scientific article

Common HLA alleles, rather than rare mutants, confer susceptibility to coeliac disease

scientific article published on 01 May 1999

Comparison of artificial neural network analysis with other multimarker methods for detecting genetic association

scientific article

Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder

scientific article

Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3.

scientific article

Confounding factors may account for the association

scientific article published in the British Medical Journal

Consider factors that are important to patients when quantifying harms

scientific article published on 6 November 2013

Consideration of plausible genetic architectures for schizophrenia and implications for analytic approaches in the era of next generation sequencing

scientific article published on February 2013

Construction of an Exome-Wide Risk Score for Schizophrenia Based on a Weighted Burden Test

scientific article published on 11 September 2017

Construction of an exome-wide risk score for schizophrenia based on a weighted burden test

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

scientific article

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder

scientific article published on 4 March 2008

Distribution of Risk Behaviour for HIV Infection Amongst Intravenous Drug Users

article

Effect of antipsychotics on stroke risk remains unproved

scientific article published in the British Medical Journal

Estimated haplotype counts from case-control samples cannot be treated as observed counts

scientific article published in April 2006

Estimation of haplotypes at DRD2 may have produced misleading results

scientific article published in August 2006

Euthanasia

Evaluation of the positional candidate gene CHRNA7 at the juvenile myoclonic epilepsy locus (EJM2) on chromosome 15q13-14.

scientific article published in April 2002

Evidence for genetic susceptibility to the alcohol dependence syndrome from the thiamine transporter 2 gene solute carrier SLC19A3.

scientific article published on June 2014

Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia

scientific article published on 08 July 2009

Exclusion of linkage of schizophrenia of the gene for the glutamate GluR5 receptor

article

Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites

article

Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior

article

Exome sequence analysis and follow up genotyping implicates rare ULK1 variants to be involved in susceptibility to schizophrenia.

scientific article published on 17 November 2017

Extended homozygosity is not usually due to cytogenetic abnormality

scientific article

Extension of conditional model-free likelihood-based linkage analysis to additive and other models

scientific article published on 01 March 2002

Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia

scientific article

Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample

scientific article

Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4).

scientific article published in April 2006

Failure to find linkage and increased homozygosity for the dopamine D3 receptor gene in Tourette's syndrome

scientific article published in The Lancet

Family association studies of markers on chromosome 2q and Type 1 diabetes in subjects from South India

scientific article published in 2000

Family linkage study of the T-cell receptor genes in coeliac disease

article

Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene

scientific article

Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3.

scientific article

Further Investigation of Linkage Disequilibrium SNPs and their Ability to Identify Associated Susceptibility Loci

scientific article published on 01 May 2004

Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees [published erratum appears in Am J Psychiatry 1997 Jan;154(1):139]

article

Genetic analysis of complex disease

scientific article published on 01 January 1995

Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia

scientific article

Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder

scientific article published on 13 January 2011

Genetic association between alleles of pancreatic phospholipase A2 gene and bipolar affective disorder

article

Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome

scientific article

Genetic association, mutation screening, and functional analysis of a Kozak sequence variant in the metabotropic glutamate receptor 3 gene in bipolar disorder.

scientific article

Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X region

scientific article published in June 2005

Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2

scientific article

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

scientific article

Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population

scientific article published on 16 April 2014

Genetic variation in the miR-708 gene and its binding targets in bipolar disorder.

scientific article

Gene–Brain Structure Relationships: Arbitrary Assumptions of Heterogeneity Generate Unfalsifiable Claims—Reply

article

Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13.

scientific article published in June 2004

Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q

Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

scientific article published on 20 June 2017

Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23

scientific article

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

article

Haplotype association analysis of discrete and continuous traits using mixture of regression models.

scientific article published in March 2004

Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians

scientific article published on May 2002

High prevalence and low fecundity of mental disorders may reflect recessive effects

scientific article published in October 2013

Identification of the Slynar gene (AY070435) and related brain expressed sequences as a candidate gene for susceptibility to affective disorders through allelic and haplotypic association with bipolar disorder on chromosome 12q24.

scientific article published in October 2006

In memoriam: Hugh Malcolm Douglas Gurling

scientific article published in December 2014

Intensive cognitive behaviour therapy for chronic schizophrenia. Specific effect of cognitive behaviour therapy for schizophrenia is not proved.

scientific article published on January 1999

Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locus

scientific article published on 18 March 2008

Investigation of Recessive Effects in Schizophrenia Using Next-Generation Exome Sequence Data

scientific article

Investigation of the Ability of Haplotype Association and Logistic Regression to Identify Associated Susceptibility Loci

scientific article published on 01 November 2006

LD scores are associated with differences in allele frequencies between populations but LD score regression can still distinguish confounding from polygenicity

scientific article published on 11 January 2020

Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia

article

Letter to the Editor: Schizophrenia does not represent the extreme of a normally distributed trait.

scientific article

Link between outcome and service quality is not clear

scientific article published in April 2013

Linkage Analysis of Manic Depression (Bipolar Affective Disorder) in Icelandic and British Kindreds using Markers on the Short Arm of Chromosome 18

scientific article published on 01 September 1997

Linkage analysis between bipolar affective disorder and markers on chromosome X.

scientific article published in January 1998

Linkage analysis of chromosome 22q12-13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families

scientific article published on 01 August 1995

Linkage analysis of idiopathic generalised epilepsy in families of probands with Juvenile Myoclonic Epilepsy and marker loci in the region of EPM 1 on chromosome 21 q: Unverricht-Lundborg disease and JME are not allelic variants

Linkage between tyrosine hydroxylase gene and affective disorder cannot be excluded in two of six pedigrees

article

Linkage disequilibrium between two highly polymorphic microsatellites.

scientific article

Linkage findings in bipolar disorder

scientific article published on 01 May 1995

Linkage studies in bipolar affective disorder with markers on chromosome 21

scientific article published on 01 December 1996

Linkage study of the D5 dopamine receptor gene (DRD5) in multiplex Icelandic and English schizophrenia pedigrees

article

Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

scientific article

Markers typed in genome-wide analysis identify regions showing deviation from Hardy-Weinberg equilibrium

scientific article

Meta-analysis of 32 genome-wide linkage studies of schizophrenia.

scientific article published on 30 December 2008

Microsatellite polymorphisms for chromosome 5 bands q11.2-q13.3.

scientific article published on May 1993

Mini-review: Update on the genetics of schizophrenia

article

Minor differences in haplotype frequency estimates can produce very large differences in heterogeneity test statistics

scientific article

Model-free analysis and permutation tests for allelic associations.

scientific article published in March 2000

Monte Carlo tests for associations between disease and alleles at highly polymorphic loci

scientific article published on 01 January 1995

Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia

scientific article

NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis

scientific article published on 17 September 2019

Neuroreceptor subunit genes and the genetic susceptibility to gilles de la tourette syndrome

article

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

scientific article

No evidence for excess runs of homozygosity in bipolar disorder.

scientific article

OCTET does not demonstrate a lack of effectiveness for community treatment orders

scientific article published on February 2014

Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia

scientific article

Patient experience - the ingredient missing from cost-effectiveness calculations

scientific article

Perception of Risk of HIV Infection by Injecting Drug Users and Effects on Medical Clinic Attendance

article

Population stratifications can cause false positive linkage results if founders are untyped

scientific article published on 01 May 1996

Possible linkage of Tourette syndrome to markers on short arm of chromosome 3 (C3p21-14)

scientific article published in The Lancet

Power comparison of parametric and nonparametric linkage tests in small pedigrees

scientific article

Practical Experience of the Application of a Weighted Burden Test to Whole Exome Sequence Data for Obesity and Schizophrenia

scientific article

Prion disease

article

Program Report: GENECOUNTING Support Programs

scientific article published on 01 March 2006

Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis

scientific article published on 17 June 2020

Psychiatry SHOs should consider psychological treatment for depression

scholarly article by Melissa Willis et al published 14 August 2007 in Clinical Governance

Psychological deficit from excessive alcohol consumption: evidence from a co-twin control study

article

Pursuing parity: genetic tests for psychiatric conditions in the UK National Health Service

scientific article published on 22 March 2019

Rare chromosomal deletions and duplications increase risk of schizophrenia

scientific article

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.

scientific article

Rare missense variants within a single gene form yin yang haplotypes

scientific article published on 22 April 2015

Rare variant analysis in multiply affected families, association studies and functional analysis suggest a role for the ITGΒ4 gene in schizophrenia and bipolar disorder.

scientific article published on 9 March 2018

Re-analysis of collaborative study on the genetics of alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299.

scientific article published in September 2004

Recurrent pyoderma in a family with a defect in leucocyte locomotion

scientific article published in the British Medical Journal

Report fails to acknowledge problems with at-home HIV test

scientific article published in The Lancet

SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent

scientific article published on 16 August 2002

Schizophrenia genetics moves into the light

article

Schizophrenia susceptibility and chromosome 6p24–22

scientific article published on 01 November 1995

Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A)

article

Should ambiguous trios for the TDT be discarded?

scientific article published on 01 November 2000

Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populations.

scientific article published on 20 January 2008

Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32.

scientific article published in January 1995

Support of association between BRD1 and both schizophrenia and bipolar affective disorder.

scientific article published in March 2010

Tests of linkage and allelic association between markers in the 1p36 PRKCZ (protein kinase C zeta) gene region and bipolar affective disorder

scientific article published on 9 January 2012

The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia

scientific article

The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability.

scientific article published on 26 June 2017

The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations

scientific article published on 01 March 2000

The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder

scientific article

The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred: linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and ty

scientific article published on April 1995

Thrombolysis in acute ischaemic stroke

Two microsatellite polymorphisms at the D5S39 locus

scientific article

Using a dummy quantitative variable to deal with multiple affection categories in genetic linkage analysis

scientific article published on 01 October 1991

Using risk calculation to implement an extended relative pair analysis

scientific article published on 01 May 1994

Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology.

scientific article

Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways

scientific article published on 05 February 2020

Whole-genome association study of bipolar disorder

scientific article

Yin yang haplotypes revisited - long, disparate haplotypes observed in European populations in regions of increased homozygosity

scientific article published on 4 March 2010

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