List of works - Gian Filippo Ruda

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

scientific article

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

scientific article published on 01 July 2006

Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

scientific article

Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds

scientific article

Assessing histone demethylase inhibitors in cells: lessons learned.

scientific article

Automated design of ligands to polypharmacological profiles.

scientific article

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates

scientific article

Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hy

scientific article

Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging

scientific article published on 27 November 2014

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

scientific article published on 14 August 2010

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

scientific article published in March 2015

Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase

scientific article published on 18 January 2011

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

scientific article published on 27 February 2015

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

scientific article

Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase

scientific article

Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase

scientific article

Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.

scientific article

Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.

scientific article

List of works by Gian Filippo Ruda

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds

Assessing histone demethylase inhibitors in cells: lessons learned.

Automated design of ligands to polypharmacological profiles.

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates

Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hy

Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase

Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase

Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.

Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.