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List of works by Paul Schaeffer

5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor

scientific article

A new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient mice

scientific article

Activation of human vascular endothelial cells by factor Xa: effect of specific inhibitors

scientific article published on 01 March 1999

Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice

scientific article published on September 2001

Antiplatelet and antithrombotic activity of SL65.0472, a mixed 5-HT1B/5-HT2A receptor antagonist

scientific article published on 01 March 2001

Antithrombotic properties of SSR182289A, a new, orally active thrombin inhibitor.

scientific article published in February 2003

CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.

scientific article published in September 2003

Characterization of cardiac angiotensin AT1 receptors by [3H]SR 47436

scientific article published on 01 October 1993

Coagulation factor Xa induces endothelium-dependent relaxations in rat aorta

scientific article published on 01 November 1997

Comparative effects of calmodulin inhibitors on calmodulin's hydrophobic sites and on the activation of cyclic nucleotide phosphodiesterase by calmodulin.

scientific article published on June 1987

Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways.

scientific article published in August 2002

Detection of bradykinin B1 receptors in rat aortic smooth muscle cells.

scientific article

Effect of SR 33805 on arterial smooth muscle cell proliferation and neointima formation following vascular injury

scientific article published on 01 July 1995

Effect of SR 47436, a novel angiotensin II AT1 receptor antagonist, on human vascular smooth muscle cells in vitro

scientific article published on 01 January 1994

Effect of SR-49059, a vasopressin V1a antagonist, on human vascular smooth muscle cells

scientific article published on 01 January 1995

Effect of SR58611A, a potent beta-3 adrenoceptor agonist, on cutaneous wound healing in diabetic and obese mice.

scientific article published in December 2005

Effect of SanOrg123781A, a synthetic hexadecasaccharide, on clot-bound thrombin and factor Xa in vitro and in vivo

scientific article published on 01 September 2003

Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo ⬇️

scientific article published on March 1, 1998

Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel

scientific article (publication date: April 2004)

Effects of bepridil and of its quaternary derivative on rat tail artery.

scientific article published in April 1986

Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs

scientific article published on 01 August 1999

Factor Xa activates endothelial cells by a receptor cascade between EPR-1 and PAR-2

scientific article published on 01 November 2000

Human umbilical vein endothelial cells express high affinity neurotensin receptors coupled to intracellular calcium release

scientific article published on 01 February 1995

Human umbilical vein endothelial cells express high affinity receptors for factor Xa

scientific article published on 01 July 1997

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

scientific article

Interaction of calmodulin and calcium antagonists with [3H]diltiazem and [3H]nitrendipine binding sites

scientific article published on 01 January 1988

Interactions of calmodulin antagonists with calcium antagonists binding sites

scientific article published on 01 April 1991

K+ efflux pathways and neurotransmitter release associated to hippocampal ischemia: effects of glucose and of K+ channel blockers

scientific article published on 01 January 1991

Lesion progression in apoE-deficient mice: implication of chemokines and effect of the AT1 angiotensin II receptor antagonist irbesartan

scientific article

Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin.

scientific article published on 30 October 2003

Neurotensin induces the release of prostacyclin from human umbilical vein endothelial cells in vitro and increases plasma prostacyclin levels in the rat

scientific article published on 01 April 1997

Nonproteolytic activation of the thrombin receptor promotes human umbilical vein endothelial cell growth but not intracellular CA2+, prostacyclin, or permeability

scientific article published on 01 February 1997

P2Y(4) nucleotide receptor: a novel actor in post-natal cardiac development.

scientific article published on 22 March 2012

PPAR expression, muscle size and metabolic rates across the gray catbird's annual cycle are greatest in preparation for fall migration

scientific article published on 29 July 2019

Pharmacokinetics of new synthetic heparin mimetics

scientific article published on 01 June 2002

Receptor sites involved in the action of calcium blocking agents.

scientific article

Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy.

scientific article published on 19 July 2008

Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice

scientific article

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

scientific journal article

SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities.

scientific article published on 14 May 2012

SR123781A, a synthetic heparin mimetic

scientific article

SR142948A is a potent antagonist of the cardiovascular effects of neurotensin

scientific article published on 01 April 1998

SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies

scientific article

SSR182289A enhances thrombolysis induced by fibrinolytic agents in rabbit models of venous and arterial thrombosis.

scientific article published in April 2004

SSR182289A, a selective and potent orally active thrombin inhibitor.

scientific article published in April 2004

The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways

scientific article

Tumor vasculature is regulated by FGF/FGFR signaling-mediated angiogenesis and bone marrow-derived cell recruitment: this mechanism is inhibited by SSR128129E, the first allosteric antagonist of FGFRs

scientific article published on January 2015

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