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List of works by Jean-Pierre J Issa

A Bayesian Model for SNP Discovery Based on Next-Generation Sequencing Data.

scientific article

A Blueprint for an International Cancer Epigenome Consortium. A Report from the AACR Cancer Epigenome Task Force ⬇️

scientific article published on November 27, 2012

A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome.

scientific article published on 11 January 2017

A microassay for measuring cytosine DNA methyltransferase activity during tumor progression

scientific article published on 01 December 1995

A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer

scientific article published on 22 May 2017

A parallel phase I/II clinical trial design for combination therapies.

scientific article published in June 2007

A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome.

scientific article published on 8 July 2014

A phase I study of decitabine with pegylated interferon α-2b in advanced melanoma: impact on DNA methylation and lymphocyte populations

scientific article published on 31 May 2014

A randomized study of decitabine versus conventional care for maintenance therapy in patients with acute myeloid leukemia in complete remission ⬇️

scientific article published on 05 June 2012

A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene.

scientific article

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

scientific article published on 3 June 2008

Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.

scientific article

Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia

scientific article published in February 2003

Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia

scientific article

Aberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia

scientific article published on 17 February 2005

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

scientific article published on 13 February 2003

Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine

scientific article published in April 2008

Age-related DNA methylation changes in normal human prostate tissues

scientific article published on 01 July 2007

Age-related epigenetic changes and the immune system ⬇️

scientific article published on October 1, 2003

Age-related epigenetic drift in the pathogenesis of MDS and AML.

scientific article published on 10 January 2014

Aging and epigenetic drift: a vicious cycle

scientific article published on 02 January 2014

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.

scientific article published on 20 June 2007

An Sp1/Sp3 binding polymorphism confers methylation protection.

scientific article

Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition

scientific article

Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.

scientific article published on October 2007

Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa

scientific article

Azacitidine

scientific article published on 01 May 2005

Azacitidine.

scientific article

BM-SNP: A Bayesian Model for SNP Calling Using High Throughput Sequencing Data.

scientific article

Biochemistry and Biology of ARHI (DIRAS3), an Imprinted Tumor Suppressor Gene Whose Expression Is Lost in Ovarian and Breast Cancers

article

CIMP, at last.

scientific article

Caloric restriction delays age-related methylation drift

scientific article published on 14 September 2017

Cancer epigenetics

scientific article published on 19 October 2010

Cancer prevention: epigenetics steps up to the plate.

scientific article published on 19 March 2008

Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

scientific article

Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers.

scientific article published in November 2010

Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract.

scientific article published on 07 March 2011

Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation.

scientific article

Colon cancer: it's CIN or CIMP

scientific article published on 01 October 2008

Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.

scientific article

Combining epigenetic and cytotoxic therapy in the treatment of solid tumors.

scientific article published in October 2007

Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation".

scientific article published in November 2003

Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas.

scientific article published in November 2003

Concordant CpG island methylation in hyperplastic polyposis.

scientific article published on February 2002

Concordant DNA methylation in synchronous colorectal carcinomas.

scientific article published on 8 September 2009

Concordant methylation of the ER and N33 genes in glioblastoma multiforme.

scientific article published in June 1998

Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique ⬇️

scientific article published on October 17, 2012

CpG island methylation in aberrant crypt foci of the colorectum

scientific article published on May 2002

CpG island methylation in gastroenterologic neoplasia: a maturing field.

scientific article

CpG island methylation profiling in human melanoma cell lines.

scientific article

CpG island methylator phenotype in cancer

scientific article published on 01 December 2004

CpG island methylator phenotype in colorectal cancer

scientific article

CpG island methylator phenotypes in aging and cancer.

scientific article

Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.

scientific article

Current and future management options for myelodysplastic syndromes

scientific article published on July 2010

DNA Demethylation-Dependent AR Recruitment and GATA Factors Drive Rhox5 Homeobox Gene Transcription in the Epididymis ⬇️

scientific article published on February 9, 2012

DNA Hypomethylating Drugs in Cancer Therapy

scientific article

DNA Methylation As a Clinical Marker in Oncology ⬇️

scientific article published on 07 May 2012

DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory ⬇️

scientific article published on January 4, 2012

DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia

scientific article published on 01 May 2006

DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia

scientific article published in July 2002

DNA methylation patterns at relapse in adult acute lymphocytic leukemia

scientific article published in June 2002

DNA methylation predicts recurrence from resected stage III proximal colon cancer ⬇️

scientific article published on November 18, 2010

DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis

scientific article

Decitabine

scientific article published on 01 November 2003

Decitabine dosing schedules.

scientific article

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

scientific article

Decitabine in the treatment of myelodysplastic syndromes.

scientific article

Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner.

scientific article published on November 2007

Demethylator phenotypes in acute myeloid leukemia

scientific article published on 07 March 2018

Detection of Bladder Cancer Using Novel DNA Methylation Biomarkers in Urine Sediments ⬇️

scientific article published on May 17, 2011

Diet, Nutrition, and Cancer Epigenetics.

scientific article published on 23 March 2016

Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications.

scientific article published on June 2004

Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.

scientific article published on 18 February 2016

Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries.

scientific article

Digital Restriction Enzyme Analysis of Methylation (DREAM).

scientific article

Dissecting DNA hypermethylation in cancer.

scientific article

Dnmt3a is essential for hematopoietic stem cell differentiation

scientific article

Dose, schedule, safety, and efficacy of guadecitabine in relapsed or refractory acute myeloid leukemia.

scientific article published on 6 December 2017

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

scientific article

Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.

scientific article published on December 2007

Effect of cytarabine and decitabine in combination in human leukemic cell lines

scientific article published on 01 July 2007

Effect of haematological improvement on survival in patients given targeted therapy as initial treatment of acute myeloid leukaemia or high-risk myelodysplastic syndrome

scientific article published on 25 June 2007

Effects ofTET2mutations on DNA methylation in chronic myelomonocytic leukemia ⬇️

scientific article published on February 1, 2012

Enrichment for Histone H3 Lysine 9 Methylation at Alu Repeats in Human Cells ⬇️

scientific article published on April 30, 2003

Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.

scientific article published in May 2003

Epigenetic aspects of MDS and its molecular targeted therapy

scientific article published on 10 October 2012

Epigenetic changes in colorectal cancer.

scientific article published on January 2004

Epigenetic changes in solid and hematopoietic tumors.

scientific article

Epigenetic changes in the myelodysplastic syndrome.

scientific article

Epigenetic control of PRV-1 expression on neutrophils.

scientific article published on November 2007

Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer.

scientific article published on 19 November 2006

Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.

scientific article

Epigenetic regulation of ARHI in breast and ovarian cancer cells

scientific article

Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties.

scientific article published on January 2013

Epigenetic synergy between decitabine and platinum derivatives

scientific article

Epigenetic variation and cellular Darwinism ⬇️

scientific article published on July 27, 2011

Epigenetics

scientific article published on 17 June 2011

Epigenetics and human disease

scientific article published on 01 March 1996

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

scientific article published on 29 January 2021

Evolution of decitabine development: accomplishments, ongoing investigations, and future strategies

scientific article

Examination of Whole Blood DNA Methylation as a Potential Risk Marker for Gastric Cancer ⬇️

scientific article published on August 13, 2013

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

scientific article published on October 1993

Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity.

scientific article published on 14 December 2017

Feasibility of therapy with hypomethylating agents in patients with renal insufficiency

scientific article

Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer

scientific article

Fusobacterium in colonic flora and molecular features of colorectal carcinoma.

scientific article

G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition.

scientific article

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

scientific article published on 18 May 2008

Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium

scientific article published on 23 January 2017

Genetic and epigenetic alterations in sentinel lymph nodes metastatic lesions compared to their corresponding primary breast tumors ⬇️

scientific article published on October 1, 2003

Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer

scientific article

Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.

scientific article

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters

scientific article

Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI.

scientific article

Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.

scientific article published on 31 March 2009

Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial

scientific article published on 03 May 2019

Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial

scientific article published on 24 August 2017

Healthcare utilization and costs associated with tyrosine kinase inhibitor switching in patients with chronic myeloid leukemia.

scientific article published on 20 October 2015

Hepatitis virus infection affects DNA methylation in mice with humanized livers.

scientific article published on 30 October 2013

High-throughput methylation profiling by MCA coupled to CpG island microarray

scientific article

Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells

scientific article published on April 2009

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

scientific article

Histone deacetylase inhibitors as anti-neoplastic agents.

scientific article

Histone deacetylase inhibitors: a review of their clinical status as antineoplastic agents.

scientific article

Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis.

scientific article published on March 2004

Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors).

scientific article published on 4 May 2007

Hypomethylation of TET2 Target Genes Identifies a Curable Subset of Acute Myeloid Leukemia

scientific article published on 13 November 2015

Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas.

scientific article

Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men.

scientific article published on 6 July 2010

Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling

scientific article published on 30 April 2008

Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results.

scientific article

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

scientific article published on 23 July 2015

Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

scientific article (publication date: 18 April 2002)

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma ⬇️

scientific article (publication date: 9 June 1998)

Increased cytosine DNA-methyltransferase activity during colon cancer progression

scientific article published on 01 August 1993

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

scholarly article

Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers

scientific article published on 25 April 2013

Introduction: emerging role of epigenetic therapy: focus on decitabine.

scientific article published in July 2005

Introductory editorial

scientific article

JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia

scientific article

LHX6 is a sensitive methylation marker in head and neck carcinomas.

scientific article

LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability

scientific article

LINE-1 methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors

scientific article

Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A.

scientific article published on 17 October 2014

MGMT promoter methylation and field defect in sporadic colorectal cancer.

scientific article

Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines

scientific article published on 17 October 2008

Mechanisms of resistance to decitabine in the myelodysplastic syndrome.

scientific article

Metabolic, hormonal and immunological associations with global DNA methylation among postmenopausal women

scientific article

Methylated CpG Island Amplification and Microarray (MCAM) for High-Throughput Analysis of DNA Methylation

scientific article published on 01 March 2008

Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer.

scientific article published on 9 January 2004

Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome

scientific article

Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system

scientific article published on 01 September 1999

Methylation of the estrogen receptor-alpha gene promoter is selectively increased in proliferating human aortic smooth muscle cells.

scientific article

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

scientific article published on 01 August 1994

Methylome sequencing for fibrolamellar hepatocellular carcinoma depicts distinctive features

scientific article

Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells

scientific article published on 6 October 2015

Mitoxantrone: a hypomethylating agent?

scientific article published in May 2003

Myelodysplastic syndromes.

scientific article

New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development

scientific article published on 4 September 2015

Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis.

scientific article published in January 2007

Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection.

scientific article

Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy

scientific article published on August 2010

P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.

scientific article published on March 2003

PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter

scientific article published on 11 July 2006

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

scientific article published on 6 November 2003

Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia

scientific article published in August 2006

Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma

scientific article

Phase I/II study of azacitidine and capecitabine/oxaliplatin (CAPOX) in refractory CIMP-high metastatic colorectal cancer: evaluation of circulating methylated vimentin

scientific article published on 16 August 2016

Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer

scientific article

Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia.

scientific article published on March 2007

Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate

scientific article published on 9 May 2005

Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation

scientific article published on 01 April 2005

Progesterone Receptor Isoform-Specific Promoter Methylation: Association ofPRAPromoter Methylation with Worse Outcome in Breast Cancer Patients ⬇️

scientific article published on June 15, 2011

Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System

scientific article

Quantitative promoter hypermethylation analysis of cancer-related genes in salivary gland carcinomas: comparison with methylation-specific PCR technique and clinical significance

scientific article

RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis.

scientific article

RPS19 and JAK2 genes are not silenced by DNA methylation in diamond blackfan anemia

scientific article published on 01 March 2007

Rare CpG Island Methylator Phenotype in Ulcerative Colitis–Associated Neoplasias

scientific article published on 25 January 2007

Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation

scientific article published in August 2003

Regulation of AURKC expression by CpG island methylation in human cancer cells.

scientific article published on 20 May 2015

Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island

scientific article

Report of a phase 1/2 study of a combination of azacitidine and cytarabine in acute myelogenous leukemia and high-risk myelodysplastic syndromes

scientific article

Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome.

scientific article

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

scientific article

Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia

scientific article (publication date: August 2003)

Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia

scientific article

Roadmap for investigating epigenome deregulation and environmental origins of cancer

scientific article published on 13 September 2017

Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome

scientific article published on 27 June 2007

Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study

scientific article

Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes.

scientific article published on 16 April 2009

Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities

scientific article published on December 2009

Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience

scientific article

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.

scientific article

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

scientific article published on 13 May 2015

Tackling the methylome: recent methodological advances in genome-wide methylation profiling

scientific article

Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer

scientific article published on 30 December 2015

Targeting the cancer epigenome for therapy

scientific article published on September 2016

The epigenome of AML stem and progenitor cells ⬇️

scientific article published on December 18, 2012

The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?

scientific article

The myelodysplastic syndrome as a prototypical epigenetic disease ⬇️

scientific article published on May 9, 2013

The promise of epigenetic therapy: reprogramming the cancer epigenome.

scientific article

The role of epigenetics in cancer. DNA Methylation, Imprinting and the Epigenetics of Cancer--an American Association for Cancer Research Special Conference. Las Croabas, Puerto Rico, 12-16 1997 December

scientific article published on 01 March 1998

Therapeutic advances in leukemia and myelodysplastic syndrome over the past 40 years

scientific article published on October 2008

Time to think outside the (genetic) box

scientific article published on 01 January 2011

Transcriptional Selectivity of Epigenetic Therapy in Cancer.

scientific article published on 22 November 2016

Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate.

scientific article

Treatment options in advanced myelodysplastic syndrome, with emphasis on epigenetic therapy.

scientific article

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

scientific article

Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome

scientific article

Widespread and tissue specific age-related DNA methylation changes in mice.

scientific article

Will next-generation agents deliver on the promise of epigenetic hypomethylation therapy?

scientific article

Zebrafish embryos as a screen for DNA methylation modifications after compound exposure.

scientific article published on 19 December 2015

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3 ⬇️

scientific article published on June 1, 1995

β-Thalassemia due to intronic LINE-1 insertion in the β-globin gene (HBB): molecular mechanisms underlying reduced transcript levels of the β-globin(L1) allele

scientific article published on 13 August 2013

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