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List of works by Thomas A. Lanz

A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing.

scientific article published on 15 October 2013

Behavioral characterization of striatal-enriched protein tyrosine phosphatase (STEP) knockout mice.

scientific article

Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease

scientific article published on 5 October 2010

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

scientific article published on 18 August 2006

Demonstration of a common artifact in immunosorbent assays of brain extracts: development of a solid-phase extraction protocol to enable measurement of amyloid-beta from wild-type rodent brain

scientific article published on 4 May 2006

Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype

scientific article

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014.

scientific article published on 30 December 2010

Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease

scientific article

Downstream effects of striatal-enriched protein tyrosine phosphatase reduction on RNA expression in vivo and in vitro.

scientific article published on 15 August 2014

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia

scientific article published on 21 January 2019

Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder

scientific article published on 18 March 2015

Factors influencing metabolic rate in naked mole-rats (Heterocephalus glaber).

scientific article published in May 1999

GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons

scientific article published on 04 June 2020

H2 histaminergic control of inhibition of eating induced by intragastric NaCl in rats

scientific article published on 01 August 1998

In search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence behind the mTor activation hypothesis

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

scientific article

Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment.

scientific article published on 19 September 2017

LRRK2 activation in idiopathic Parkinson's disease.

scientific article published in July 2018

Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

scientific article published on 30 August 2004

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function

scientific article published on 6 February 2012

Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.

scientific article published on 12 November 2007

Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.

scientific article

Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma

scientific article published on 7 June 2012

STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder

scientific article

Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

scientific article published on 19 February 2021

Solid-phase extraction enhances detection of beta-amyloid peptides in plasma and enables Abeta quantification following passive immunization with Abeta antibodies

scientific article published on 22 November 2007

Structural basis of C-terminal β-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease

scientific article

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

scientific article

The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

scientific article published on 6 March 2003

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

scientific article

Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

scientific article

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