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List of works by Keith L Ligon

A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients

scientific article

A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma

scientific article

AT-36PANOBINOSTAT IN COMBINATION WITH BEVACIZUMAB FOR RECURRENT GLIOBLASTOMA AND ANAPLASTIC GLIOMA

ATIM-32. PERSONALIZED NEOANTIGEN-TARGETING VACCINE GENERATES ROBUST SYSTEMIC AND INTRATUMORAL T CELL RESPONSES IN GLIOBLASTOMA (GBM) PATIENTS

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

scientific article published on August 2008

Array-based genomics in glioma research

scientific article published on 03 March 2009

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

BM-07GENOMIC CHARACTERIZATION OF BRAIN METASTASES REVEALS BRANCHED EVOLUTION AND METASTASIS-SPECIFIC MUTATIONS

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

scientific article published on 04 February 2019

CRX is a diagnostic marker of retinal and pineal lineage tumors

scientific article

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma

scientific article

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

scientific article published on September 2014

Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG

scientific article

Correction to: DNA methylation-based reclassification of olfactory neuroblastoma

scientific article published on 01 September 2018

Current clinical development of PI3K pathway inhibitors in glioblastoma ⬇️

scientific article published on May 22, 2012

DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues

scientific article

DNA methylation-based reclassification of olfactory neuroblastoma

scientific article published on 05 May 2018

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

scientific article published in April 2018

Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice

scientific article

Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors.

scientific article published on June 2007

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

scientific article published on 26 September 2015

Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas

scientific article published on 9 November 2016

Glioma models: new GEMMs add "class" with genomic and expression correlations.

scientific article

HG-76SPATIAL AND TEMPORAL HOMOGENEITY OF DRIVER MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA.

scientific article published on 30 May 2016

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

scientific article published on 20 November 2020

Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients

scientific article published on April 2015

INNV-13. ALLELE: A CONSORTIUM FOR PROSPECTIVE GENOMICS AND FUNCTIONAL DIAGNOSTICS TO GUIDE PATIENT CARE AND TRIAL ANALYSIS IN NEWLY-DIAGNOSED GLIOBLASTOMA

Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies.

scientific article

Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma

scientific article published on 27 March 2019

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

scientific article published on 28 September 2019

LG-02MYB-QKI REARRANGEMENTS IN ANGIOCENTRIC GLIOMA DRIVE TUMORIGENICITY THROUGH A TRIPARTITE MECHANISM.

scientific article published on 30 May 2016

MNGO-01A PROGNOSTIC CYTOGENETIC SCORING SYSTEM TO GUIDE THE ADJUVANT MANAGEMENT OF PATIENTS WITH ATYPICAL MENINGIOMA.

scientific article

MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

scientific article published on 07 May 2020

Mechanisms and therapeutic implications of hypermutation in gliomas

scientific article published on 15 April 2020

Meningioangiomatosis associated with meningioma: a case report

scientific article published on 01 January 2009

Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade

scientific article published on 27 November 2018

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

scientific article published on 19 December 2018

Neoplastic cells are a rare component in human glioblastoma microvasculature ⬇️

scientific article published on January 1, 2012

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

scientific article published on 28 January 2016

PATH-16. MOLECULAR PATHOLOGY AND CLINICAL CHARACTERISTICS OF MMR DEFICIENCY (MMRd) IN DIFFUSE GLIOMAS

PHASE II TRIAL OF THE PHOSPHATIDYINOSITOL-3 KINASE (PI3K) INHIBITOR BUPARLISIB (BKM120) IN RECURRENT GLIOBLASTOMA CONDUCTED BY THE IVY FOUNDATION EARLY PHASE CLINICAL TRIALS CONSORTIUM.

scientific article published in July 2014

Phase 2 study of dose-intense temozolomide in recurrent glioblastoma

scientific article

Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02

scientific article published on 26 January 2014

Phase II study of monthly pasireotide LAR (SOM230C) for recurrent or progressive meningioma

scientific article

Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic glioma

scientific article

Phase II trial of ponatinib in patients with bevacizumab-refractory glioblastoma

scientific article published on 24 August 2019

Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas.

scientific article published on 22 October 2014

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

scientific article

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

scientific article published on 01 August 2019

Resolving medulloblastoma cellular architecture by single-cell genomics

scientific article published on 24 July 2019

Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone

scientific article published on 3 October 2017

Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution

scientific article

Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma

scientific article published in 2022

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

scientific article published on 01 July 2020

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

scientific article published on 6 April 2016

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

scientific article

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

scientific article published in 2022

VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system

scientific article published in 2022

p16INK4a induces an age-dependent decline in islet regenerative potential

scientific article

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