List of works - Tim Forshew

Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

scientific article published in June 2009

Analysis of circulating tumor DNA to monitor metastatic breast cancer

scientific article (publication date: 28 March 2013)

Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling.

scientific article published on 15 March 2018

Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma.

scientific article published on 29 October 2013

Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro

scientific article published on 25 July 2013

Digital PCR analysis of circulating tumor DNA: a biomarker for chondrosarcoma diagnosis, prognostication, and residual disease detection.

scientific article

Identification of novel TYR and TYRP1 mutations in oculocutaneous albinism

scientific article published on 01 August 2005

MAPK pathway activation and the origins of pediatric low-grade astrocytomas.

scientific article published on March 2010

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas ⬇️

scientific article published on November 3, 2010

Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways

scientific article

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

scientific article published on May 2013

Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome

scientific article

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

scientific article (publication date: 2 May 2013)

Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.

scientific article

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

scientific article

RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology

scientific article published on 10 March 2011

RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort.

scientific article published on 9 May 2010

Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex

scientific article published on 10 October 2008

Replication timing profile reflects the distinct functional and genomic features of the MHC class II region.

scientific article

Targeted therapy for BRAFV600E malignant astrocytoma.

scientific article published on 28 October 2011

Three different brain tumours evolving from a common origin

scientific article published on April 2013

List of works by Tim Forshew

Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

Analysis of circulating tumor DNA to monitor metastatic breast cancer

Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling.

Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma.

Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro

Digital PCR analysis of circulating tumor DNA: a biomarker for chondrosarcoma diagnosis, prognostication, and residual disease detection.

Identification of novel TYR and TYRP1 mutations in oculocutaneous albinism

MAPK pathway activation and the origins of pediatric low-grade astrocytomas.

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas ⬇️

Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology

RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort.

Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex

Replication timing profile reflects the distinct functional and genomic features of the MHC class II region.

Targeted therapy for BRAFV600E malignant astrocytoma.

Three different brain tumours evolving from a common origin