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List of works by Stephen C Mack

"PEAR-ing" Genomic and Epigenomic Analyses for Cancer Gene Discovery.

scientific article published on October 2015

"miR miR on the wall, who's the most malignant medulloblastoma miR of them all?"

scientific article published on 2 June 2017

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

scientific article published on 19 February 2016

A functional genomics approach to identify pathways of drug resistance in medulloblastoma

scientific article published on 27 December 2018

An epigenetic gateway to brain tumor cell identity

scientific article published on December 2015

CDC20 maintains tumor initiating cells

scientific article

Cancer stem cells in glioblastoma

scientific article published in June 2015

Childhood cerebellar tumours mirror conserved fetal transcriptional programs

scientific article published on 01 May 2019

Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

scientific article published in 2021

Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

scientific article

Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination

scientific article published on 06 December 2016

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

EPND-01. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS.

scientific article published on 31 May 2017

Emerging insights into the ependymoma epigenome

scientific article published on March 2013

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

scientific article

Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell carcinoma.

scientific article published on 10 June 2013

FORETINIB IS EFFECTIVE THERAPY FOR METASTATIC SONIC HEDGEHOG MEDULLOBLASTOMA.

scientific article published in July 2014

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

scientific article

Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma

scientific article published on 23 September 2014

Genomic Analysis of Childhood Brain Tumors: Methods for Genome-Wide Discovery and Precision Medicine Become Mainstream.

scientific article published on 22 June 2017

H3 K27M mutations are extremely rare in posterior fossa group A ependymoma

scientific article published on 16 June 2017

H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone

scientific article published on 23 September 2020

Heterogeneity within the PF-EPN-B ependymoma subgroup

article

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

scientific article published on 20 November 2020

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome.

scientific article published on 07 February 2017

Hypermutation of the inactive X chromosome is a frequent event in cancer

scientific article published on 17 October 2013

Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma.

scientific article

Impact of radiation therapy and extent of resection for ependymoma in young children: A population-based study

scientific article published on 8 November 2017

Intertumoral and intratumoral heterogeneity as a barrier for effective treatment of medulloblastoma.

scientific article published on August 2013

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015

MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells.

scientific article published on 20 July 2017

Medulloblastoma comprises four distinct molecular variants

scientific article published on 07 September 2010

Medulloblastoma subgroups remain stable across primary and metastatic compartments

scientific article

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

scientific article

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

scientific article

Molecular genetics of ependymoma ⬇️

scientific article published on October 1, 2011

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

scientific article published on 16 June 2018

Nestin expression identifies ependymoma patients with poor outcome

scientific article published on 30 May 2012

Nicotinamide metabolism regulates glioblastoma stem cell maintenance

scientific article

PCDH10 is a candidate tumour suppressor gene in medulloblastoma.

scientific article published on 20 May 2011

PDTM-23. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

scientific article

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

scientific article

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.

scientific article published on 27 March 2017

Put away your microscopes: the ependymoma molecular era has begun.

scientific article published on 6 September 2017

RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation

scientific article published on 20 June 2016

Response

Short Review: The role and contribution of transcriptional enhancers in brain cancer

scientific article published on 28 February 2020

Spatial heterogeneity in medulloblastoma

scientific article published on 10 April 2017

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

scientific article

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

scientific article published on 9 October 2017

Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells

scientific article published on 01 August 2019

Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

scientific article

The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

scientific article published on 23 July 2020

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

scientific article

The epigenetics of brain tumors.

scientific article published on January 2012

The genetic and epigenetic basis of ependymoma.

scientific article published on 18 June 2009

The genetics of pediatric brain tumors

scientific article published on May 2010

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

scientific article published on 20 December 2017

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

scientific article

Transposase-driven rearrangements in human tumors.

scientific article published in June 2017

Weighing ependymoma as an epigenetic disease

scientific article published on 22 September 2020

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