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List of works by Stephen C Mack

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Medulloblastoma comprises four distinct molecular variants

scientific article published on 07 September 2010
Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article
Cancer stem cells in glioblastoma

scientific article published in June 2015
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

scientific article
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

scientific article
Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

scientific article
Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

scientific article
Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

scientific article
A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

scientific article published on 19 February 2016
Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014
Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

scientific article published on 9 October 2017
Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

scientific article
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013
The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

scientific article
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

scientific article
Spatial heterogeneity in medulloblastoma

scientific article published on 10 April 2017
An epigenetic gateway to brain tumor cell identity

scientific article published on December 2015
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

scientific article published on 20 December 2017
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016
Medulloblastoma subgroups remain stable across primary and metastatic compartments

scientific article
MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015
Hypermutation of the inactive X chromosome is a frequent event in cancer

scientific article published on 17 October 2013
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.

scientific article published on 27 March 2017
The genetics of pediatric brain tumors

scientific article published on May 2010
The genetic and epigenetic basis of ependymoma.

scientific article published on 18 June 2009
Childhood cerebellar tumours mirror conserved fetal transcriptional programs

scientific article published on 01 May 2019
Nestin expression identifies ependymoma patients with poor outcome

scientific article published on 30 May 2012
Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination

scientific article published on 06 December 2016
CDC20 maintains tumor initiating cells

scientific article
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

scientific article published on 16 June 2018
Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

scientific article
MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells

scientific article published on 20 July 2017
Nicotinamide metabolism regulates glioblastoma stem cell maintenance

scientific article
The epigenetics of brain tumors.

scientific article published on January 2012
Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome.

scientific article published on 07 February 2017
RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation

scientific article published on 20 June 2016
Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

scientific article
Molecular genetics of ependymoma

scientific article published on October 1, 2011
Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell carcinoma.

scientific article published on 10 June 2013
Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

scientific article
PCDH10 is a candidate tumour suppressor gene in medulloblastoma.

scientific article published on 20 May 2011
Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma

scientific article published on 23 September 2014
Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma.

scientific article
Genomic Analysis of Childhood Brain Tumors: Methods for Genome-Wide Discovery and Precision Medicine Become Mainstream.

scientific article published on 22 June 2017
Heterogeneity within the PF-EPN-B ependymoma subgroup

article
H3 K27M mutations are extremely rare in posterior fossa group A ependymoma

scientific article published on 16 June 2017
Intertumoral and intratumoral heterogeneity as a barrier for effective treatment of medulloblastoma.

scientific article published on August 2013
Emerging insights into the ependymoma epigenome

scientific article published on March 2013
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells

scientific article published on 01 August 2019

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