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List of works by Christopher K Glass

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

scientific article

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

scientific article

A Global Clustering Algorithm to Identify Long Intergenic Non-Coding RNA - with Applications in Mouse Macrophages ⬇️

scientific article published on September 30, 2011

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

scientific journal article

A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism

scientific article published on 26 August 2013

A comprehensive classification system for lipids

scientific article

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors

scientific article (publication date: 20 February 2004)

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

scientific article

A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela

article

A mouse macrophage lipidome

scientific article

A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation

scholarly article

A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.

scientific article

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

scientific article published on 04 October 2007

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

scientific article published on June 2006

Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway

scientific journal article

Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

scientific article

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

scientific article published on 04 July 2016

An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation

scientific journal article

An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses

scientific article published in November 2017

An environment-dependent transcriptional network specifies human microglia identity

scientific article published on 25 May 2017

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation

scientific article

Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.

scientific article published on 17 May 2018

Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages

scientific article published on 17 June 2013

Anti-inflammatory and antidiabetic roles of PPARgamma.

scientific article

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

scientific article

Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice

scientific article published on 13 February 2020

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association

scientific article published on 14 November 2019

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.

scientific article published on 9 April 2018

Combinatorial roles of nuclear receptors in inflammation and immunity

scientific article

Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment

scientific article

Considering the kinetics of mRNA synthesis in the analysis of the genome and epigenome reveals determinants of co-transcriptional splicing.

scientific article

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization

scientific article

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.

scientific article published on 23 August 2012

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

scientific journal article

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

scientific article published on 03 March 2020

Coregulators and Inflammation

Corepressor-dependent silencing of chromosomal regions encoding neuronal genes

scientific article (publication date: 29 November 2002)

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

scientific article

Cx3cr1-deficient microglia exhibit a premature aging transcriptome

scientific article published on 02 December 2019

DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation

scientific article

DRES-15. IL11 SECRETION BY GLIOBLASTOMA ASSOCIATED MICROGLIA DEFINE A STAT3-MYC SIGNALING AXIS THAT IS SUPPRESSED IN “EXCEPTIONAL RESPONDERS”

Daniel Steinberg, 1922-2015.

scientific article published on 24 July 2015

Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis

scientific article published on 30 October 2003

Deconstructing repression: evolving models of co-repressor action

scientific article published on February 2010

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages

article published in the Proceedings of the National Academy of Sciences of the United States of America

Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function.

scientific article published on 31 October 2016

Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis

scientific article published in July 2007

Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma

scientific article

Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.

scientific article

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

scientific article published in Nature Communications

Effect of natural genetic variation on enhancer selection and function.

scientific article published on 13 October 2013

Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy

scientific article

Enhancer RNAs and regulated transcriptional programs

scientific article

Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules

scholarly article

Environment drives selection and function of enhancers controlling tissue-specific macrophage identities

scientific article

Epigenomics: Roadmap for regulation

scientific article published in February 2015

Erratum: Corrigendum: Eya protein phosphatase activity regulates Six1–Dach–Eya transcriptional effects in mammalian organogenesis

scientific article published in Nature

Evidence mandating earlier and more aggressive treatment of hypercholesterolemia

scientific article published on August 2008

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

scientific article (publication date: 12 July 2002)

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

scientific article published on 27 December 2018

Exploiting genomics and natural genetic variation to decode macrophage enhancers

scientific article

Expression analysis of G Protein-Coupled Receptors in mouse macrophages

scientific article

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis

scientific article (publication date: 20 November 2003)

Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice

scientific article

Factor XIIIA (cross)links AT1 receptors to atherosclerosis

scientific article

Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection

scientific article

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

scientific article

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

scientific article

Gaining weight: the Keystone Symposium on PPAR and LXR.

scientific article published on August 2005

Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

scientific article

Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate

scientific article

Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation

scientific article

Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock.

scientific article published on 20 December 2017

Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors

scientific article

Human promoters are intrinsically directional

scientific article

Inflammation and lipid signaling in the etiology of insulin resistance ⬇️

scientific article published on May 2, 2012

Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism ⬇️

scientific article published on February 8, 2011

Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter

scientific article

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

scientific article

Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4.

scientific article

Kdo2-Lipid A, a TLR4-specific Agonist, Induces de Novo Sphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy ⬇️

scientific article published on September 27, 2010

LMSD: LIPID MAPS structure database

scientific article

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

scientific article published on 03 October 2019

Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State

scientific article published on February 2017

Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia

scientific article

MAGGIE: leveraging genetic variation to identify DNA sequence motifs mediating transcription factor binding and function

scientific article published on 01 July 2020

MARGE: Mutation Analysis for Regulatory Genomic Elements

MMARGE: Motif Mutation Analysis for Regulatory Genomic Elements

Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid.

scientific article

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

scientific article published on 24 May 2007

Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression

scientific article published on 23 January 2020

Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway

scientific article

Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies

scientific article

Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray

scientific article published in March 2002

Mechanisms Underlying the Selection and Function of Macrophage-Specific Enhancers

scientific article

Mechanisms establishing TLR4-responsive activation states of inflammatory response genes.

scientific article

Mechanisms of Regulated Gene Transcription

article

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

scientific article published on 28 September 2020

Migration of fibrocytes in fibrogenic liver injury

scientific article

Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas

scientific article published on 07 May 2009

Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression.

scientific article published on June 2006

Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases

scientific article published on February 2014

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

scientific article published on September 2005

Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors.

scientific article published on 08 September 2011

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

scientific article

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling.

scientific article published on 29 September 2017

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

scientific article

NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids

scientific article

NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes

scientific article published on 14 May 2018

Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis

scientific article published on 21 November 2019

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

scientific article published on 28 April 2020

Non-coding RNAs as regulators of gene expression and epigenetics.

scientific article

Nuclear receptor coregulators: multiple modes of modification

scientific article

Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules

scientific article

Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules

scientific article published on 01 July 2008

Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer

scientific article

Nuclear receptors versus inflammation: mechanisms of transrepression

scientific article

Nuclei isolation of multiple brain cell types for omics interrogation

scientific article published on 25 January 2021

Opposing LSD1 complexes function in developmental gene activation and repression programmes

scientific article

Origin of myofibroblasts in the fibrotic liver in mice

scientific article

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

scientific article published in Nature

PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation

scientific article

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

scientific article

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

scientific article published on 13 August 2019

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

scientific article published on 16 October 2004

PPARs and Lipid Ligands in Inflammation and Metabolism ⬇️

scientific article published on October 12, 2011

Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

scientific article

Perspectives on Unidirectional versus Divergent Transcription

scientific article published in November 2015

Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice

scientific article

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

scientific article

Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

scientific article

Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate

scientific article

Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression

scientific article published on August 2003

Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

scientific article published in Nature

Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling

scientific article

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

scientific article

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

scientific article by H. Cho et al., published in March 2012

Regulatory network of microRNAs in RAW 264.7 macrophage cells

scientific article published on January 1, 2010

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

scientific article published on August 2013

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

2011 thesis

Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells

scientific article

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.

scientific article published on 02 June 2013

Review focus on epigenetics and the histone code in vascular biology

scientific article published on June 2011

Roles of lineage-determining transcription factors in establishing open chromatin: lessons from high-throughput studies

scientific article published on January 2012

SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer

scientific article published on 24 April 2019

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

scientific journal article

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

scientific article published on 21 December 2016

Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters.

scholarly article

Serum Response Factor Indirectly Regulates Type I Interferon-Signaling in Macrophages ⬇️

scientific article published on May 25, 2013

Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages

scientific article

Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice

scientific article published on 17 January 2019

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

scientific article

Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype

scientific article

Statins enhance formation of phagocyte extracellular traps

scientific article published on November 2010

Sterols and oxysterols in immune cell function

scientific article published on September 2013

Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

scientific article published on March 2017

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity

scientific article

Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine.

scientific article published on 9 October 2017

Systems biology of macrophages.

scientific article published on January 2007

TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints

scientific article

TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism.

scientific article

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins

scientific article published in January 2018

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins

scientific article published on 01 March 2018

The Interferon Stimulated Gene 12 Inactivates Vasculoprotective Functions of NR4A Nuclear Receptors ⬇️

scientific article published on March 15, 2012

The Transcriptional Specificity of NF-κB Dimers Is Coded within the κB DNA Response Elements ⬇️

scientific article published on October 11, 2012

The coming of age of Langerhans cell histiocytosis

scientific article published on 01 January 2020

The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs

scientific article

The macrophage foam cell as a target for therapeutic intervention

scientific article

The role of transcription factors in allergic inflammation

scientific article

The selection and function of cell type-specific enhancers

scientific article

The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response

scientific article published on 27 December 2012

Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

scientific article published on 28 September 2017

Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

scientific article published on 27 July 2016

Transcription factor ISL1 is essential for pacemaker development and function.

scientific article

Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation.

scientific article published on 2 November 2015

Transcriptional control of microglia phenotypes in health and disease.

scientific article

Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint

scientific article

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

scientific article published on 6 June 2017

Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung

scientific article published on 20 January 2020

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

scientific article

Vespucci: a system for building annotated databases of nascent transcripts

scientific article published on 04 December 2013

ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis

scientific article published on 10 April 2020

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