List of works - Jingshan Ren

High resolution structures of HIV-1 RT from four RT-inhibitor complexes

scientific article

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

scientific article

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

scientific article

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

scientific article

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

scientific article

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors

scientific article

Picornavirus uncoating intermediate captured in atomic detail

scientific article

Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase

scientific article

Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors

scientific article

In situ macromolecular crystallography using microbeams

scientific article published on 17 April 2012

Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors.

scientific article

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

scientific article

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

scientific article published on 29 June 2016

The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

scientific article

Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

scientific article published on 03 March 2008

Hepatitis A virus and the origins of picornaviruses

scientific article

Crystal structure of human α-lactalbumin at 1·7 Å resolution

scientific article published on 01 September 1991

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

scientific article

A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.

scientific article published on August 1999

Structural and functional insights of RANKL-RANK interaction and signaling

scientific article

Outrunning free radicals in room-temperature macromolecular crystallography

scientific article published on 15 June 2012

More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

scientific article

The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases

scientific article

Molecular architecture and ligand recognition determinants for T4 RNA ligase

scientific article published in November 2005

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design

scientific article

A plate-based high-throughput assay for virus stability and vaccine formulation

scientific article published on 26 June 2012

Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding

scientific article

Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme.

scientific article

Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.

scientific article

Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives

scientific article

Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity

scientific article

Exploiting fast detectors to enter a new dimension in room-temperature crystallography

scientific article

The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators

scientific article

Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor

scientific article

Structures of R- and T-state Escherichia coli aspartokinase III. Mechanisms of the allosteric transition and inhibition by lysine

scientific article

Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses

scientific article

Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues

scientific article

High-speed fixed-target serial virus crystallography

scientific article

Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants

scientific article

Continuous and Discontinuous Changes in the Unit Cell of HIV-1 Reverse Transcriptase Crystals on Dehydration

article

Crystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound Forms

scientific article

Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus

scientific article

The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin

scientific article

3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes

scientific article

Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

scientific article published in February 2004

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

scientific article published on 19 June 2020

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.

scientific article

Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article

Structure of Ljungan virus provides insight into genome packaging of this picornavirus.

scientific article

HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistance

scientific article

List of works by Jingshan Ren

High resolution structures of HIV-1 RT from four RT-inhibitor complexes

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors

Picornavirus uncoating intermediate captured in atomic detail

Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase

Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors

In situ macromolecular crystallography using microbeams

Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors.

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

Hepatitis A virus and the origins of picornaviruses

Crystal structure of human α-lactalbumin at 1·7 Å resolution

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.

Structural and functional insights of RANKL-RANK interaction and signaling

Outrunning free radicals in room-temperature macromolecular crystallography

More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases

Molecular architecture and ligand recognition determinants for T4 RNA ligase

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design

A plate-based high-throughput assay for virus stability and vaccine formulation

Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding

Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme.

Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.

Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives

Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity

Exploiting fast detectors to enter a new dimension in room-temperature crystallography

The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators

Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor

Structures of R- and T-state Escherichia coli aspartokinase III. Mechanisms of the allosteric transition and inhibition by lysine

Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses

Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues

High-speed fixed-target serial virus crystallography

Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants

Continuous and Discontinuous Changes in the Unit Cell of HIV-1 Reverse Transcriptase Crystals on Dehydration

Crystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound Forms

Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus

The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin

3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes

Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.

Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors

Structure of Ljungan virus provides insight into genome packaging of this picornavirus.

HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistance