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List of works by Heather P Harding

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

scientific article

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

scientific article

A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma.

scientific article

A method to quantify FRET stoichiometry with phasor plot analysis and acceptor lifetime ingrowth

scientific article

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb

scientific article

A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains.

scientific article

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

scientific article

A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity

scientific article

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

scientific journal article

Activating transcription factor 4 is translationally regulated by hypoxic stress

scientific article published on September 2004

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.

scientific article

Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling

scientific article

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

scientific article (publication date: March 2003)

Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2.

scientific article published on 14 January 2011

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

scientific article published in March 2018

Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, eIF2B

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression

scientific article published on December 2005

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

scientific article published in June 2001

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

scientific journal article

CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI

scientific journal article

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

scientific article published on 27 July 2004

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload

scientific journal article

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

scientific article

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

scientific article

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

scientific article

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

scientific article published on 12 January 2017

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

scientific article

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

scientific journal article

Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

scientific article published on October 1995

Dual role of the integrated stress response in medulloblastoma tumorigenesis

scientific article published on September 2016

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

scientific article (publication date: June 2000)

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

scientific journal article

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

scientific article published on 8 September 2005

ERO1-?, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis.

scientific article published in May 2010

ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

scientific journal article

Endoplasmic reticulum stress and the development of diabetes: a review

scientific article

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

scientific article

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

scientific journal article

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma

scientific article published on 25 September 2008

Establishing a Flow Process to Coumarin-8-Carbaldehydes as Important Synthetic Scaffolds

scientific article published on 10 July 2012

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

scientific journal article

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

scientific article

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

scientific article

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

scientific article published in May 2005

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

scientific article published on 10 January 2019

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

scientific article

Higher-order phosphatase-substrate contacts terminate the integrated stress response

scientific article published on 08 October 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

scientific article (publication date: 3 January 2002)

Immunohistochemical localization of a low molecular weight surfactant-associated protein in human lung.

scientific article published in November 1987

Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice

scientific article

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

scientific journal article

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis

scientific article

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

scientific article

Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

scientific article published on 27 February 2006

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate

scientific article published in June 2012

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

scientific journal article

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes

scientific journal article

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides

scientific article

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation

scientific article published on 12 November 2007

Novel function of PERK as a mediator of force-induced apoptosis

scientific article published on 11 June 2008

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis

scientific article published on April 2013

PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis

scientific article published on 12 May 2016

PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases

scientific article

Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

scientific article

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

scientific article

Perk is essential for translational regulation and cell survival during the unfolded protein response

scientific article (publication date: May 2000)

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

scientific article

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

scientific article

Postnatal stimulation of rat surfactant protein A synthesis by dexamethasone

scientific article published on 01 August 1989

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

scholarly article

Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation

scientific article

RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling

retracted scientific article published on May 2013

Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate

scientific article published on 27 September 2005

Regulated translation initiation controls stress-induced gene expression in mammalian cells

scientific journal article

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum

scientific article

Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

scientific article published in April 2018

Role for the obesity-related FTO gene in the cellular sensing of amino acids

scientific article published on 28 January 2013

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

scientific journal article

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

scientific article

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification

scientific article published on October 2013

Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism

scientific article published on 20 October 2015

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

scientific article

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound

scientific article

Stress-induced gene expression requires programmed recovery from translational repression

scientific article

Targeting the unfolded protein response in disease.

scientific article published on September 2013

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

scientific journal article

The Utility of Postmortem Lung for RNA Studies; Variability and Correlation of the Expression of Surfactant Proteins in Human Lung ⬇️

scientific article published on 01 January 1991

The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation

scientific article published on 28 June 2013

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

scientific article published on 10 August 2003

The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage

scientific article published on February 2007

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

scientific article

The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat

scientific article published on September 1995

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

scientific article published on 21 November 2019

Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p

scientific article

Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development

scientific article

Transcriptional and translational control in the Mammalian unfolded protein response

scientific article

Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux

scientific article

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

scientific article

Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.

scientific article

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

scientific article published on December 2004

Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease

scientific article

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

scientific article published on 17 August 2005

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

scientific article

Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

scientific article

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