List of works - Federico Forneris

8 Demethylation pathways for histone methyllysine residues

scientific article published in 2006

A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1.

scientific article published on 20 September 2006

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

scientific article published on 11 August 2021

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

scientific article published on 04 March 2019

A novel mammalian flavin-dependent histone demethylase

scientific journal article

Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system

scientific article

Analysis in a murine model points to IgG responses against the 34k2 salivary proteins from Aedes albopictus and Aedes aegypti as novel promising candidate markers of host exposure to Aedes mosquitoes

scientific article published on 16 October 2019

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

scientific article

Author Correction: Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

scientific article published in Nature Communications

Autosomal Recessive Keratoderma-Ichthyosis-Deafness (ARKID) Syndrome Is Caused by VPS33B Mutations Affecting Rab Protein Interaction and Collagen Modification

scientific article published on 22 December 2016

Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections

scientific article

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

scientific article

CDH1 Mutation Distribution and Type Suggests Genetic Differences between the Etiology of Orofacial Clefting and Gastric Cancer

scientific article published on 03 April 2020

Complement Factor D

Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization

scientific article

Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)

scientific article published on 22 April 2022

Crystallization and preliminary X-ray analysis of an alditol oxidase from Streptomyces coelicolor A3(2).

scientific article published on 30 November 2006

Deconstruction of Neurotrypsin Reveals a Multi-factorially Regulated Activity Affecting Myotube Formation and Neuronal Excitability

scientific article published in 2022

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

scientific article published on September 2016

Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

scientific article

Enzymes without borders: mobilizing substrates, delivering products

scientific article published on July 2008

Expanding the structural biology toolbox with single-molecule holography

scientific article published on 2 February 2017

Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

scientific article published in April 2005

Human histone demethylase LSD1 reads the histone code

scientific article

Identifying and Visualizing Macromolecular Flexibility in Structural Biology

scientific article

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

scientific article

Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

scholarly article by Silvia Buroni et al published 2018 in Frontiers in Pharmacology

LSD1: oxidative chemistry for multifaceted functions in chromatin regulation

scientific article published on 17 March 2008

Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations

scientific article

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

scientific article published in Nature Communications

Multiple pathways guide oxygen diffusion into flavoenzyme active sites

scientific article

New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin

scientific article published on 14 July 2009

Persistence of Anti-SARS-CoV-2 Antibodies in Non-Hospitalized COVID-19 Convalescent Health Care Workers

scientific article published on 01 October 2020

Phasing protein structures using the group-subgroup relation

scientific article

Polymorphism analyses and protein modelling inform on functional specialization of Piwi clade genes in the arboviral vector Aedes albopictus

scientific article published on 02 December 2019

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features

scientific article

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis

scientific article (publication date: 20 July 2016)

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

scientific article

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

scientific article published on 24 March 2016

Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase

scientific article

Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity

scientific article

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

scientific article

Structural characterization of the third scavenger receptor cysteine-rich domain of murine neurotrypsin

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

scientific article

Structures of C3b in complex with factors B and D give insight into complement convertase formation

scientific article

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

scientific article

The Crystal Structure of Burkholderia cenocepacia DfsA Provides Insights into Substrate Recognition and Quorum Sensing Fatty Acid Biosynthesis

scientific article

The modular serine proteases of the complement cascade

scientific article published on 03 May 2012

The three-dimensional structure of "Lonely Guy" from Claviceps purpurea provides insights into the phosphoribohydrolase function of Rossmann fold-containing lysine decarboxylase-like proteins

scientific article

ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding

scientific article

List of works by Federico Forneris

8 Demethylation pathways for histone methyllysine residues

A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1.

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

A novel mammalian flavin-dependent histone demethylase

Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system

Analysis in a murine model points to IgG responses against the 34k2 salivary proteins from Aedes albopictus and Aedes aegypti as novel promising candidate markers of host exposure to Aedes mosquitoes

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

Author Correction: Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

Autosomal Recessive Keratoderma-Ichthyosis-Deafness (ARKID) Syndrome Is Caused by VPS33B Mutations Affecting Rab Protein Interaction and Collagen Modification

Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

CDH1 Mutation Distribution and Type Suggests Genetic Differences between the Etiology of Orofacial Clefting and Gastric Cancer

Complement Factor D

Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization

Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)

Crystallization and preliminary X-ray analysis of an alditol oxidase from Streptomyces coelicolor A3(2).

Deconstruction of Neurotrypsin Reveals a Multi-factorially Regulated Activity Affecting Myotube Formation and Neuronal Excitability

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

Enzymes without borders: mobilizing substrates, delivering products

Expanding the structural biology toolbox with single-molecule holography

Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

Human histone demethylase LSD1 reads the histone code

Identifying and Visualizing Macromolecular Flexibility in Structural Biology

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

LSD1: oxidative chemistry for multifaceted functions in chromatin regulation

Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

Multiple pathways guide oxygen diffusion into flavoenzyme active sites

New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin

Persistence of Anti-SARS-CoV-2 Antibodies in Non-Hospitalized COVID-19 Convalescent Health Care Workers

Phasing protein structures using the group-subgroup relation

Polymorphism analyses and protein modelling inform on functional specialization of Piwi clade genes in the arboviral vector Aedes albopictus

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase

Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

Structural characterization of the third scavenger receptor cysteine-rich domain of murine neurotrypsin

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

Structures of C3b in complex with factors B and D give insight into complement convertase formation

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

The Crystal Structure of Burkholderia cenocepacia DfsA Provides Insights into Substrate Recognition and Quorum Sensing Fatty Acid Biosynthesis

The modular serine proteases of the complement cascade

The three-dimensional structure of "Lonely Guy" from Claviceps purpurea provides insights into the phosphoribohydrolase function of Rossmann fold-containing lysine decarboxylase-like proteins

ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding

Versatile medium-throughput strategies for recombinant expression screening in structural biology