List of works - Scott R Burrows

A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism

scientific article

A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition

scientific article

A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

scientific article published on 01 May 2001

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

scientific article

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

scientific article

A case report: immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy.

scientific article published in March 1997

A comparison of Epstein-Barr virus-specific T-cell immunity in malaria-endemic and -nonendemic regions of Papua New Guinea.

scientific article published in June 1983

A mechanism for the HLA-A*01-associated risk for EBV+ Hodgkin lymphoma and infectious mononucleosis

scientific article published on 01 September 2008

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

scientific article

A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule

scientific article

A structural voyage toward an understanding of the MHC‐I‐restricted immune response: lessons learned and much to be learned ⬇️

scientific article published on November 1, 2012

Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease.

scientific article published on August 1999

Allelic polymorphism in the T cell receptor and its impact on immune responses

scientific article

Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry

scientific article published on 8 September 2006

An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3) ⬇️

scientific article published on January 1, 1990

An HLA-A2-restricted T-cell epitope mapped to the BNLF2a immune evasion protein of Epstein-Barr virus that inhibits TAP.

scientific article published on 07 January 2009

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

scientific article

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

scientific article published on 21 May 2009

Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection

scientific article published on 15 December 2010

BLT esterase activity as an alternative to chromium release in cytotoxic T cell assays

scientific article published on December 1991

Bystander apoptosis induced by CD8+ cytotoxic T cell (CTL) clones: implications for CTL lytic mechanisms.

scientific article published on September 1993

CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines.

scientific article published in December 2012

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria

scientific article published on 22 May 2014

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

scientific article published on 27 September 2016

Calcium concentration defines two stages in transformation of lymphocytes by Epstein-Barr virus.

scientific article published in May 1984

Coinfection with Human Cytomegalovirus Genetic Variants in Transplant Recipients and Its Impact on Antiviral T Cell Immune Reconstitution

scientific article published on 8 June 2016

Cross-reactive recognition of viral and self-peptides by a "public" T cell receptor expressed by cytotoxic T lymphocytes expanded in multiple unrelated individuals.

scientific article

Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognition.

scientific article

Cytotoxic T lymphocyte discrimination between type A Epstein-Barr virus transformants is mapped to an immunodominant epitope in EBNA 3.

scientific article published in February 1991

Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis.

scientific article

Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis

scientific article published on 20 January 2017

Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis.

scientific article

Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.

scientific article

Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells

scientific article published on 31 August 2012

Endoplasmic reticulum signal sequence facilitated transport of peptide epitopes restores immunogenicity of an antigen processing defective tumour cell line.

scientific article published on April 1994

Engineered T cell receptors and their potential in molecular medicine

scientific article published on January 2006

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

scientific article published on 15 June 2016

Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation

scientific article published on 19 October 2011

Epstein-Barr virus specific T-cell response in nasopharyngeal carcinoma patients.

scientific article published in September 1983

Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis

scientific article published on 3 February 2014

Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3.

scientific article published on September 1994

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

scientific article

HLA peptide length preferences control CD8+ T cell responses

scientific article

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.

scientific article published in May 1998

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

scientific article

Have we cut ourselves too short in mapping CTL epitopes?

scientific article published on 16 November 2005

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance

scientific article

Highly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I Molecule

scientific article

Human immunology: a case for the ascent of non‐furry immunology ⬇️

scientific article published on 01 March 2011

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling

scientific article published on January 2013

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

scientific article published on 5 February 2016

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

scientific article

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection

scientific article

Inhibition of HLA B8-restricted recognition by unrelated peptides: evidence for allosteric inhibition

article

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

scientific article published in August 1996

Interleukin-2 receptors in infectious mononucleosis

scientific article published on 01 December 1989

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

scientific article published on 26 February 2010

Molecular Imprint of Exposure to Naturally Occurring Genetic Variants of Human Cytomegalovirus on the T cell Repertoire

scientific article published on 10 February 2014

Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood

scientific article published on 05 February 2014

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

scientific article

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

scientific article

Oligopeptide Induction of a Secondary Cytotoxic T-cell Response to Epstein-Barr Virus In Vitro ⬇️

scientific article published on April 1, 1991

Patterns of reactivity of Epstein-Barr virus-specific T cells in A-type donor cultures after reactivation with autologous A- or B-type transformants

scientific article published in April 1990

Peptide length determines the outcome of TCR/peptide-MHCI engagement

scientific article

Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis

scientific article

Presentation of endogenous viral peptide epitopes by anti-CD40 stimulated human B cells following recombinant vaccinia infection.

scientific article published in August 1993

Strains of Epstein-Barr virus infecting multiple sclerosis patients.

scientific article

Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells

scientific article published on 23 July 2020

T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells

scientific article

T cell allorecognition and MHC restriction--A case of Jekyll and Hyde?

scientific article published on 14 September 2007

T cell allorecognition via molecular mimicry

scientific article

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

scientific article published on 25 September 2005

T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen

scientific article

T-cell allorecognition: a case of mistaken identity or déjà vu?

scientific article

T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years

scientific article

T-cell receptor bias and immunity

scientific article published on 18 January 2008

T-cells behaving badly: structural insights into alloreactivity and autoimmunity

scientific article published on 12 August 2008

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.

scientific article published on 17 October 2016

Targeting of EBNA1 for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+ T cell recognition.

scientific article

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

article

The Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I Molecule

scientific article

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

scientific article

The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma

scientific article

The impact of a large and frequent deletion in the human TCR β locus on antiviral immunity

scientific article

The influence of antiviral T-cell responses on the alloreactive repertoire.

scientific article

The shaping of T cell receptor recognition by self-tolerance

scientific article

The specificity of recognition of a cytotoxic T lymphocyte epitope

scientific article published on 01 January 1992

Understanding human T‐cell‐mediated immunoregulation through herpesviruses ⬇️

scientific article published on 08 February 2011

Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response

scientific article published in June 2008

List of works by Scott R Burrows

A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism

A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition

A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

A case report: immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy.

A comparison of Epstein-Barr virus-specific T-cell immunity in malaria-endemic and -nonendemic regions of Papua New Guinea.

A mechanism for the HLA-A*01-associated risk for EBV+ Hodgkin lymphoma and infectious mononucleosis

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule

A structural voyage toward an understanding of the MHC‐I‐restricted immune response: lessons learned and much to be learned ⬇️

Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease.

Allelic polymorphism in the T cell receptor and its impact on immune responses

Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry

An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3) ⬇️

An HLA-A2-restricted T-cell epitope mapped to the BNLF2a immune evasion protein of Epstein-Barr virus that inhibits TAP.

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection

BLT esterase activity as an alternative to chromium release in cytotoxic T cell assays

Bystander apoptosis induced by CD8+ cytotoxic T cell (CTL) clones: implications for CTL lytic mechanisms.

CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines.

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

Calcium concentration defines two stages in transformation of lymphocytes by Epstein-Barr virus.

Coinfection with Human Cytomegalovirus Genetic Variants in Transplant Recipients and Its Impact on Antiviral T Cell Immune Reconstitution

Cross-reactive recognition of viral and self-peptides by a "public" T cell receptor expressed by cytotoxic T lymphocytes expanded in multiple unrelated individuals.

Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognition.

Cytotoxic T lymphocyte discrimination between type A Epstein-Barr virus transformants is mapped to an immunodominant epitope in EBNA 3.

Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis.

Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis

Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis.

Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.

Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells

Endoplasmic reticulum signal sequence facilitated transport of peptide epitopes restores immunogenicity of an antigen processing defective tumour cell line.

Engineered T cell receptors and their potential in molecular medicine

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation

Epstein-Barr virus specific T-cell response in nasopharyngeal carcinoma patients.

Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis

Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3.

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

HLA peptide length preferences control CD8+ T cell responses

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Have we cut ourselves too short in mapping CTL epitopes?

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance

Highly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I Molecule

Human immunology: a case for the ascent of non‐furry immunology ⬇️

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection

Inhibition of HLA B8-restricted recognition by unrelated peptides: evidence for allosteric inhibition

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

Interleukin-2 receptors in infectious mononucleosis

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

Molecular Imprint of Exposure to Naturally Occurring Genetic Variants of Human Cytomegalovirus on the T cell Repertoire

Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Oligopeptide Induction of a Secondary Cytotoxic T-cell Response to Epstein-Barr Virus In Vitro ⬇️

Patterns of reactivity of Epstein-Barr virus-specific T cells in A-type donor cultures after reactivation with autologous A- or B-type transformants

Peptide length determines the outcome of TCR/peptide-MHCI engagement

Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis

Presentation of endogenous viral peptide epitopes by anti-CD40 stimulated human B cells following recombinant vaccinia infection.

Strains of Epstein-Barr virus infecting multiple sclerosis patients.

Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells

T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells

T cell allorecognition and MHC restriction--A case of Jekyll and Hyde?

T cell allorecognition via molecular mimicry

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen

T-cell allorecognition: a case of mistaken identity or déjà vu?

T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years

T-cell receptor bias and immunity

T-cells behaving badly: structural insights into alloreactivity and autoimmunity

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.

Targeting of EBNA1 for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+ T cell recognition.