List of works - Matthew E. Poynter

A Comparative Study of Lung Host Defense in Murine Obesity Models. Insights into Neutrophil Function

scientific article

A common pathway to obesity and allergic asthma

scientific article published on April 2015

A computational model of unresolved allergic inflammation in chronic asthma

scientific article

A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults

scientific article published on 13 December 2012

A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation.

scientific article published in June 2003

Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice

scientific article published on 5 July 2013

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice

scientific article published on April 2016

Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice

scientific article published on March 2016

Acrolein exposure suppresses antigen-induced pulmonary inflammation

scientific article published on 16 October 2013

Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophilia

scientific article

Activation of NK1.1+ T cells in vitro and their possible role in age-associated changes in inducible IL-4 production.

scientific article published in July 1997

Active catabolism of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase in vivo is a necessary requirement for natural resistance to infection with Listeria monocytogenes

scientific article published on 01 January 1997

Acute lung injury with endotoxin or NO2 does not enhance development of airway epithelium from bone marrow

scientific article

Age-Associated Alterations in Splenic iNOS Regulation: Influence of Constitutively Expressed IFN-γ and Correction Following Supplementation with PPARα Activators or Vitamin E

scientific article published on 01 August 1999

Airway Epithelial NF- B Activation Modulates Asbestos-Induced Inflammation and Mucin Production In Vivo

scientific article published on 01 February 2007

Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen

scientific article

Airway epithelial NF-κB activation promotes the ability to overcome inhalational antigen tolerance

scientific article published on July 2015

Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure

scientific article

Airway epithelial regulation of allergic sensitization in asthma

scientific article

Aligning mouse models of asthma to human endotypes of disease

scientific article

Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells

scientific article published in January 2014

Antigen-induced mast cell expansion and bronchoconstriction in a mouse model of asthma

scientific article

Aspergillus fumigatus Generates an Enhanced Th2-Biased Immune Response in Mice with Defective Cystic Fibrosis Transmembrane Conductance Regulator

article

Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells

scientific article

Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice

scientific article

Constitutive activation of NF-kappa B in an animal model of aging

article

Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow

scientific article published on January 2009

Debugging Obesity-related Airway Hyperresponsiveness by Modulating the Microbiome

scientific article published on 01 December 2019

Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma

scientific article

Dietary saturated fat and monounsaturated fat have reversible effects on brain function and the secretion of pro-inflammatory cytokines in young women

scientific article published on 9 August 2016

Dissecting the inflammatory twitch in allergically inflamed mice

scientific article published on 04 March 2016

Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injury

scientific article published on 9 November 2009

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

scientific article published on December 2016

Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease

scientific article published on 06 May 2016

Effects of acute and chronic low density lipoprotein exposure on neutrophil function.

scientific article published on 17 October 2012

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation

scientific article

Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis

scientific article published on 24 December 2013

Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent manner

scientific article published on 11 August 2003

Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling

scientific article

Epithelial, dendritic, and CD4(+) T cell regulation of and by reactive oxygen and nitrogen species in allergic sensitization.

scientific article published on 21 March 2011

Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation

scientific article published on 15 July 2016

Flagellar motility is a key determinant of the magnitude of the inflammasome response to Pseudomonas aeruginosa

scientific article published on 25 March 2013

Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection

scientific article

H(1)R expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis

scientific article

Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility

scientific article published on 22 July 2013

Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system

scientific article published on 5 December 2011

Hyperleptinemia is associated with impaired pulmonary host defense.

scientific article published on June 2016

IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.

scientific article

Immunological characteristics and management considerations in obese patients with asthma

scientific article

Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.

scientific article

Inflammasome Activity in Non-Microbial Lung Inflammation

scientific article

Inhalation of the reactive aldehyde acrolein promotes antigen sensitization to ovalbumin and enhances neutrophilic inflammation

scientific article

Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration

scientific article

Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease

scientific article published on May 2013

Interleukin-6 as a biomarker for asthma: hype or is there something else?

scientific article published on October 2016

Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity

scientific article published on 07 October 2020

Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes

scientific article

Mechanisms of Asthma in Obesity. Pleiotropic Aspects of Obesity Produce Distinct Asthma Phenotypes

scientific article published on 17 February 2016

Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status

scientific article published on 29 January 2013

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome

scientific article

Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung

scientific article

Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo

scientific article

NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness

scientific article

NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization

scientific journal article

Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse

scientific article published on 05 August 2005

Nitrogen dioxide promotes allergic sensitization to inhaled antigen

scientific article

Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control

scientific article published on May 2009

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness

scientific article published on 8 February 2008

Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury

scientific article

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

scientific article published in Journal of Biological Chemistry

Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

scientific article (publication date: 22 September 2016)

Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis

scientific article published on 26 December 2008

Pregnant serum induces neuroinflammation and seizure activity via TNFα.

scientific article published on 16 January 2012

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness

scientific article

Pulmonary Stromal-Derived Factor-1 Expression and Effect on Neutrophil Recruitment during Acute Lung Injury

scientific article published on 01 June 2007

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

scientific article

Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium

scientific article

Reactive nitrogen species-induced cell death requires Fas-dependent activation of c-Jun N-terminal kinase

scientific article published on August 2004

Relationship between synovial fluid ARGS-aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross-sectional study

scientific article

Reply: What About Neutrophils in Obese Asthma?

scientific article

Serum Amyloid A3 is required for normal lung development and survival following influenza infection

scientific article published in Scientific Reports

Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice

scientific article

Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells

scientific article published on 05 September 2013

Serum amyloid A3 is required for normal weight and immunometabolic function in mice

scientific article published in February 2018

Slam haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT cell number and function

scientific article published on 7 June 2010

Soy biodiesel and petrodiesel emissions differ in size, chemical composition and stimulation of inflammatory responses in cells and animals

scientific article

Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation

scientific article

Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci

scientific article published in November 2003

Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products

scientific article published on March 2009

The Duffy antigen receptor for chemokines regulates asthma pathophysiology

scientific article published on 4 May 2017

The Temporal Evolution of Airways Hyperresponsiveness and Inflammation

scientific article published on January 2012

The endogenous Th17 response in NO2-promoted allergic airway disease is dispensable for airway hyperresponsiveness and distinct from Th17 adoptive transfer

scientific article published on 19 September 2013

The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins

scientific article

The inflammatory twitch as a general strategy for controlling the host response

scientific article

The role of CD1d-restricted NKT cells in the clearance of Pseudomonas aeruginosa from the lung is dependent on the host genetic background

scientific article published on 13 April 2015

The role of iNKT cells on the phenotypes of allergic airways in a mouse model

The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury.

scientific article published on February 2014

The tick salivary protein, Salp15, inhibits the development of experimental asthma

scientific article

Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotype

scientific article

Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism

scientific article published on 27 July 2016

Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma

scientific article published on 11 April 2016

List of works by Matthew E. Poynter

A Comparative Study of Lung Host Defense in Murine Obesity Models. Insights into Neutrophil Function

A common pathway to obesity and allergic asthma

A computational model of unresolved allergic inflammation in chronic asthma

A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults

A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation.

Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice

Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice

Acrolein exposure suppresses antigen-induced pulmonary inflammation

Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophilia

Activation of NK1.1+ T cells in vitro and their possible role in age-associated changes in inducible IL-4 production.

Active catabolism of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase in vivo is a necessary requirement for natural resistance to infection with Listeria monocytogenes

Acute lung injury with endotoxin or NO2 does not enhance development of airway epithelium from bone marrow

Age-Associated Alterations in Splenic iNOS Regulation: Influence of Constitutively Expressed IFN-γ and Correction Following Supplementation with PPARα Activators or Vitamin E

Airway Epithelial NF- B Activation Modulates Asbestos-Induced Inflammation and Mucin Production In Vivo

Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen

Airway epithelial NF-κB activation promotes the ability to overcome inhalational antigen tolerance

Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure

Airway epithelial regulation of allergic sensitization in asthma

Aligning mouse models of asthma to human endotypes of disease

Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells

Antigen-induced mast cell expansion and bronchoconstriction in a mouse model of asthma

Aspergillus fumigatus Generates an Enhanced Th2-Biased Immune Response in Mice with Defective Cystic Fibrosis Transmembrane Conductance Regulator

Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells

Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice

Constitutive activation of NF-kappa B in an animal model of aging

Crosstalk between CXCR4/stromal derived factor-1 and VLA-4/VCAM-1 pathways regulates neutrophil retention in the bone marrow

Debugging Obesity-related Airway Hyperresponsiveness by Modulating the Microbiome

Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma

Dietary saturated fat and monounsaturated fat have reversible effects on brain function and the secretion of pro-inflammatory cytokines in young women

Dissecting the inflammatory twitch in allergically inflamed mice

Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injury

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease

Effects of acute and chronic low density lipoprotein exposure on neutrophil function.

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation

Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis

Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent manner

Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling

Epithelial, dendritic, and CD4(+) T cell regulation of and by reactive oxygen and nitrogen species in allergic sensitization.

Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation

Flagellar motility is a key determinant of the magnitude of the inflammasome response to Pseudomonas aeruginosa

Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection

H(1)R expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis

Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility

Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system

Hyperleptinemia is associated with impaired pulmonary host defense.

IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.

Immunological characteristics and management considerations in obese patients with asthma

Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.

Inflammasome Activity in Non-Microbial Lung Inflammation

Inhalation of the reactive aldehyde acrolein promotes antigen sensitization to ovalbumin and enhances neutrophilic inflammation

Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration

Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease

Interleukin-6 as a biomarker for asthma: hype or is there something else?

Kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in COVID-19 patients as a function of age, biological sex and disease severity

Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes

Mechanisms of Asthma in Obesity. Pleiotropic Aspects of Obesity Produce Distinct Asthma Phenotypes

Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome

Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung

Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo

NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness

NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization

Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse

Nitrogen dioxide promotes allergic sensitization to inhaled antigen

Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness

Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis

Pregnant serum induces neuroinflammation and seizure activity via TNFα.

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness

Pulmonary Stromal-Derived Factor-1 Expression and Effect on Neutrophil Recruitment during Acute Lung Injury

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium

Reactive nitrogen species-induced cell death requires Fas-dependent activation of c-Jun N-terminal kinase

Relationship between synovial fluid ARGS-aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross-sectional study