List of works - Volodymyr Tryndyak

Acetaminophen-induced acute liver injury in HCV transgenic mice.

scientific article published on 29 November 2012

Aloin, a Component of the Aloe Vera Plant Leaf, Induces Pathological Changes and Modulates the Composition of Microbiota in the Large Intestine of F344/N Male Rats

scientific article published on 19 May 2017

Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin

scientific article

An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

scientific article

Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells

scientific article published on December 2015

Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells.

scientific article published on 2 January 2018

Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum

scientific article

Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver

scientific article

Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet

scientific article published on 11 October 2010

Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis

scientific article

Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice

scientific journal article

Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats

scientific article published on August 2008

Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice

scientific article

Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan

scientific article

Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet

scientific article

E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells

scientific article

Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis

scientific journal article

Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro

scientific article

Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice

scientific article published on 15 May 2014

Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene

scientific article

Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet.

scientific article published on 30 July 2008

Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats.

scientific article

Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.

scientific article

Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets

scientific article published on 01 March 2007

Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis

scientific article published in March 2007

Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.

scientific article published on 10 November 2017

Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus

scientific article published on 01 October 2005

Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study

scientific article published on 7 July 2016

Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis

scientific article published on 14 July 2007

Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice

scientific article

Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver

scientific article published on 12 August 2014

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet

scientific article published on 03 May 2009

Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma

scientific article published on 16 April 2018

Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells.

scientific article published on 9 June 2006

In vivo expression and characteristics of novel alpha-D-mannose-rich glycoprotein markers of apoptotic cells

scientific article published on 20 October 2005

Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice

scientific article

Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure

scientific article published on 04 February 2007

Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation.

scientific article published on 16 May 2017

Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice ⬇️

scientific article published on June 6, 2012

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice

scientific article

Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism

scientific article published on 19 August 2014

Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism

scientific article

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.

scientific article

Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin

scientific article

Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure

scientific article published on 28 June 2016

Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats

scientific article

Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver

scientific article published on July 2008

Methyl deficiency, alterations in global histone modifications, and carcinogenesis

scientific journal article

MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells

scientific article published on 24 November 2015

MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency

scientific article published on 21 October 2015

MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis

scientific article published in August 2017

MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis

scientific article published on 19 October 2015

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

scientific article

Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents

scientific article published on 12 March 2013

Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.

scientific article

Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet

scientific article

Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach

scientific article published on 26 July 2013

Role of ferritin alterations in human breast cancer cells

scientific article published in February 2011

Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation

scientific article published on 18 June 2008

Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

scientific article

Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury

scientific article published on 25 February 2013

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.

scientific article published on 22 March 2016

The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway

scientific article published on 08 April 2013

The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene

scientific article published on 25 February 2010

The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation

scientific article published on 6 January 2009

Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis

scientific article

List of works by Volodymyr Tryndyak

Acetaminophen-induced acute liver injury in HCV transgenic mice.

Aloin, a Component of the Aloe Vera Plant Leaf, Induces Pathological Changes and Modulates the Composition of Microbiota in the Large Intestine of F344/N Male Rats

Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin

An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells

Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells.

Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum

Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver

Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet

Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis

Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis

Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice

Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats

Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice

Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan

Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet

E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells

Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis

Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro

Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice

Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene

Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet.

Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats.

Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.

Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets

Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis

Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.

Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus

Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study

Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis

Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice

Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet

Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma

Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells.

In vivo expression and characteristics of novel alpha-D-mannose-rich glycoprotein markers of apoptotic cells

Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice

Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure

Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation.

Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice ⬇️

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice

Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism

Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.

Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin

Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure

Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats

Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver

Methyl deficiency, alterations in global histone modifications, and carcinogenesis

MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells

MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency

MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis

MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents

Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.

Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet

Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach

Role of ferritin alterations in human breast cancer cells

Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation

Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice

Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury

Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.

The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway

The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene

The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation

Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis