List of works - Jonas T. Treebak

5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice

scientific article published on 22 February 2012

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

scientific article

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

scientific article published on 01 August 2018

A randomized placebo-controlled trial of nicotinamide riboside+pterostilbene supplementation in experimental muscle injury in elderly subjects

scientific article published in 2022

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

scientific article published on 5 August 2009

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

scientific article published on 09 January 2019

AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD

scientific article

AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle

scientific journal article

AMPK and insulin action--responses to ageing and high fat diet

scientific article

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

scientific article published on 20 March 2014

AMPK in skeletal muscle function and metabolism.

scientific article published on 14 December 2017

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

scientific article published on 01 July 2006

ARDD 2020: from aging mechanisms to interventions

scientific article published on 30 December 2020

AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans

scientific article

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle

scientific article published on 18 November 2013

Acute exercise remodels promoter methylation in human skeletal muscle.

scientific article

Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle

scientific article published on 01 July 2019

Age-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat.

scientific article published on 18 October 2017

Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS

scientific article published on 01 September 2019

Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p

scientific article

Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo

scientific article published on 12 June 2013

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

scientific article published on 11 October 2019

Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways, and transcription factors

scientific article

Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

scientific article

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

scientific article published on 08 September 2020

Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity

scientific article published on 01 November 2019

Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.

scientific article

Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals

article

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

scientific article published on 26 October 2016

Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity

scientific article published in April 2005

Fasting- and ghrelin-induced food intake is regulated by NAMPT in the hypothalamus

scientific article published on 14 January 2020

Fiber type-specific effects of acute exercise on insulin-stimulated AS160 phosphorylation in insulin-resistant rat skeletal muscle

scientific article published on 01 October 2019

GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

scientific article published on 8 March 2012

Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free mice

article

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

scientific journal article

Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice.

scientific article published on 4 August 2009

Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet

scientific article published on 29 May 2015

Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice

scientific article published in February 2018

Hepatocyte-specific perturbation of NAD<sup>+</sup> biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes

scientific article published on 08 November 2021

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle

scientific article

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.

scientific article

Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

scientific article published on 31 October 2007

Impairments in site-specific AS160 phosphorylation and effects of exercise training.

scientific article published on 25 June 2013

Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle.

scientific article published on 25 October 2011

Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD<sup>+</sup> without impacting respiratory capacity or insulin sensitivity

scientific article published on 02 February 2022

Lack of AMPKα2 enhances pyruvate dehydrogenase activity during exercise

scientific article published on 21 August 2007

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

scientific article published in 2021

Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3RORγtIL-17 Tregs and improve metabolism

Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity

scientific article published on 18 July 2019

Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle

scientific article published on 31 January 2011

NAMPT-mediated NAD+ biosynthesis is indispensable for adipose tissue plasticity and development of obesity.

scientific article

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men

scientific article published on 26 December 2019

Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model.

scientific article published on 28 December 2017

Perturbations of NAD salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

scientific article

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

scientific article published on 28 February 2009

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

scientific article

ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

scientific article published on 07 December 2023

Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation.

scientific article published on 15 January 2016

Role of 5'AMP-activated protein kinase in skeletal muscle.

scientific article published on September 2008

Role of AMP-Activated Protein Kinase for Regulating Post-exercise Insulin Sensitivity.

scientific article published on January 2016

Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle

scientific article

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle

scientific article published on 25 September 2008

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling

scientific article

Sevoflurane Impairs Insulin Secretion and Tissue-Specific Glucose Uptake In Vivo

scientific article published on 24 August 2018

Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status

scientific article published on 28 August 2018

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity.

scientific article published on 24 February 2018

Sucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in mice

scientific article

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.

scientific article

Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise.

scientific article published on 29 May 2014

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

scientific article published on 05 November 2018

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

scientific article published on 18 April 2019

Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle.

scientific article published on 18 March 2014

Underpowered or negative? A crucial distinction

scientific article published on 25 March 2019

Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action

scientific article published on 07 February 2019

List of works by Jonas T. Treebak

5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

A randomized placebo-controlled trial of nicotinamide riboside+pterostilbene supplementation in experimental muscle injury in elderly subjects

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD

AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle

AMPK and insulin action--responses to ageing and high fat diet

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

AMPK in skeletal muscle function and metabolism.

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

ARDD 2020: from aging mechanisms to interventions

AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle

Acute exercise remodels promoter methylation in human skeletal muscle.

Aerobic and resistance exercise training reverses age-dependent decline in NAD+ salvage capacity in human skeletal muscle

Age-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat.

Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS

Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p

Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways, and transcription factors

Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity

Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.

Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity

Fasting- and ghrelin-induced food intake is regulated by NAMPT in the hypothalamus

Fiber type-specific effects of acute exercise on insulin-stimulated AS160 phosphorylation in insulin-resistant rat skeletal muscle

GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free mice

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice.

Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet

Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice

Hepatocyte-specific perturbation of NAD<sup>+</sup> biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.

Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Impairments in site-specific AS160 phosphorylation and effects of exercise training.

Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle.

Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD<sup>+</sup> without impacting respiratory capacity or insulin sensitivity

Lack of AMPKα2 enhances pyruvate dehydrogenase activity during exercise

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3RORγtIL-17 Tregs and improve metabolism

Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity

Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle

NAMPT-mediated NAD+ biosynthesis is indispensable for adipose tissue plasticity and development of obesity.

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men

Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model.

Perturbations of NAD salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation.

Role of 5'AMP-activated protein kinase in skeletal muscle.

Role of AMP-Activated Protein Kinase for Regulating Post-exercise Insulin Sensitivity.

Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling

Sevoflurane Impairs Insulin Secretion and Tissue-Specific Glucose Uptake In Vivo

Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity.

Sucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in mice

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.

Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise.

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle.

Underpowered or negative? A crucial distinction

Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action