List of works - Dina Robaa

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

scientific article published on 2 March 2018

A novel non-phenolic dibenzazecine derivative with nanomolar affinities for dopamine receptors

scientific article published on 01 March 2011

Analysis of the Resistance of Hepatitis C Virus NS5B Polymerase Inhibitors via Docking and Molecular Dynamics Simulation

scientific article

Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position

scientific article

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).

scientific article

Chiral indolo[3,2-f][3]benzazecine-type dopamine receptor antagonists: synthesis and activity of racemic and enantiopure derivatives.

scientific article published on 29 September 2011

Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold

scientific article published on 27 July 2017

Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists.

scientific article

Enantiomerically Pure 2-Methyltetrahydro-3-benzazepin-1-ols Selectively Blocking GluN2B Subunit Containing N-Methyl-D-aspartate Receptors.

scientific article

Epigenetic small molecule modulators of histone and DNA methylation

scientific article published on 24 March 2018

Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.

scientific article

Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases

scientific article

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors

scientific article

Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation

scientific article published on 18 December 2017

Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1.

scientific article

KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases

scientific article

Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives

scientific article published on 27 February 2017

Mind the methyl: methyllysine binding proteins in epigenetic regulation

scientific article published on 21 January 2014

Molecular combination of the dopamine and serotonin scaffolds yield in novel antipsychotic drug candidates - characterization by in vivo experiments.

scientific article published on 5 April 2012

Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features

scientific article

Peptide backbone conformation affects the substrate preference of protein arginine methyltransferase I.

scientific article published on 27 June 2012

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

scientific article published in June 2017

Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)

Residues at the indole-NH of LE300 modulate affinities and selectivities for dopamine receptors

scientific article published on 11 November 2010

Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study ofAspergillus nidulansmethionine sulfoxide reductase A and mutant enzymes

scientific article published on 08 June 2016

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

scientific article published on 30 November 2017

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

scientific article

Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation

scientific article published on 6 December 2017

Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases

scientific article

Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum

scientific article published on 23 December 2016

List of works by Dina Robaa

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

A novel non-phenolic dibenzazecine derivative with nanomolar affinities for dopamine receptors

Analysis of the Resistance of Hepatitis C Virus NS5B Polymerase Inhibitors via Docking and Molecular Dynamics Simulation

Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).

Chiral indolo[3,2-f][3]benzazecine-type dopamine receptor antagonists: synthesis and activity of racemic and enantiopure derivatives.

Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold

Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists.

Enantiomerically Pure 2-Methyltetrahydro-3-benzazepin-1-ols Selectively Blocking GluN2B Subunit Containing N-Methyl-D-aspartate Receptors.

Epigenetic small molecule modulators of histone and DNA methylation

Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.

Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors

Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation

Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1.

KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases

Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives

Mind the methyl: methyllysine binding proteins in epigenetic regulation

Molecular combination of the dopamine and serotonin scaffolds yield in novel antipsychotic drug candidates - characterization by in vivo experiments.

Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features

Peptide backbone conformation affects the substrate preference of protein arginine methyltransferase I.

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)

Residues at the indole-NH of LE300 modulate affinities and selectivities for dopamine receptors

Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study ofAspergillus nidulansmethionine sulfoxide reductase A and mutant enzymes

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation

Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases

Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum