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List of works by Uwe Schlattner

A 9-wk docosahexaenoic acid-enriched supplementation improves endurance exercise capacity and skeletal muscle mitochondrial function in adult rats.

scientific article published on 8 December 2015

A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance

scientific article (publication date: February 2000)

A two-dimensional screen for AMPK substrates identifies tumor suppressor fumarate hydratase as a preferential AMPKα2 substrate ⬇️

scientific article published on April 3, 2012

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.

scientific article published on 14 July 2006

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes

scientific article

Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA

scientific article published in 2024

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

scientific article published on 9 January 2006

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

scientific article

Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply

scientific article

Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin

scientific article published on 21 June 2006

An automated home-built low-cost fermenter suitable for large-scale bacterial expression of proteins in Escherichia coli

scientific article published on 01 August 2008

Binding of adenylate kinase to RNA

scientific article published on 01 December 1995

Bypassing AMPK Phosphorylation

scientific article published on 01 May 2014

Calcium and energy transfer

scientific article published on 01 June 2005

Cardiac phosphoproteome reveals cell signaling events involved in doxorubicin cardiotoxicity.

scientific article

Cardiac system bioenergetics: metabolic basis of the Frank-Starling law.

scientific article

Cardiolipin Clusters and Membrane Domain Formation Induced by Mitochondrial Proteins

scientific article published on 13 October 2006

Cell-Free Protein Synthesis Enhancement from Real-Time NMR Metabolite Kinetics: Redirecting Energy Fluxes in Hybrid RRL Systems.

scientific article

Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites.

scientific article published on 18 June 2016

Characterization and production of protein complexes by co-expression in Escherichia coli

scientific article published on January 2015

Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis

scientific article published on 08 May 2019

Conserved regulatory elements in AMPK ⬇️

scientific article published on June 13, 2013

Creatine and neurotrophin-4/5 promote survival of nitric oxide synthase-expressing interneurons in striatal cultures.

scientific article published on 28 November 2005

Creatine kinase and creatine transporter in normal, wounded, and diseased skin

scientific article (publication date: March 2002)

Creatine kinase in human erythrocytes: A genetic anomaly reveals presence of soluble brain-type isoform

scientific article published on 18 March 2017

Creatine kinase: an enzyme with a central role in cellular energy metabolism

scientific article published on 01 September 1998

Creatine kinases: a cornerstone for structural research in the phosphagen kinase family.

scientific article published in January 2010

Creatine promotes the GABAergic phenotype in human fetal spinal cord cultures.

scientific article

Creatine transporters: a reappraisal.

scientific article published on January 2004

Creatine treatment promotes differentiation of GABA-ergic neuronal precursors in cultured fetal rat spinal cord.

scientific article published in July 2007

Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues

scientific article (publication date: 10 January 2003)

Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase

scientific article published on 30 August 2006

Divergent Enzyme Kinetics and Structural Properties of the Two Human Mitochondrial Creatine Kinase Isoenzymes

scientific article published on 01 November 2000

Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch

journal article published in 2013

Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes.

scientific article published on 6 January 2010

Ecdysteroid receptors and their applications in agriculture and medicine.

scientific article

Effects of creatine supplementation in cystic fibrosis: results of a pilot study.

scientific article published in December 2003

Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue.

scientific article published in January 2005

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells.

scientific article published on 7 March 2005

Expressing creatine kinase in transgenic tobacco--a first step towards introducing an energy buffering system in plants

scientific article published in February 2002

Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues.

scientific article published on 14 November 2013

Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation

scientific journal article

Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach

scientific article published on 01 July 1998

Functional expression of arginine kinase improves recovery from pH stress of Escherichia coli.

scientific article published in July 2003

Functional expression of phosphagen kinase systems confers resistance to transient stresses in Saccharomyces cerevisiae by buffering the ATP pool.

scientific article published on 29 May 2002

Functions and effects of creatine in the central nervous system.

scientific article published on 24 March 2008

Genetically Encoded Fluorescent Biosensors to Explore AMPK Signaling and Energy Metabolism.

scientific article published on January 2016

Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro

scientific journal article

Higher respiratory rates and improved creatine stimulation in brain mitochondria isolated with anti-oxidants.

scientific article published in June 2004

Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis.

scientific article

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.

scientific article published on 03 August 2009

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

scientific article published on 21 May 2003

Impact of myocardial inflammation on cytosolic and mitochondrial creatine kinase activity and expression.

scientific article published on 3 February 2009

Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy

scientific article published on 27 February 2019

Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress.

scientific article

Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation

scientific article published on 30 July 2018

Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation.

scientific article published on 5 March 2003

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

scientific article

Interaction of NDPK-D with cardiolipin-containing membranes: Structural basis and implications for mitochondrial physiology.

scientific article published on 28 February 2009

Inverse metabolic engineering with phosphagen kinase systems improves the cellular energy state

scientific article published in July 2004

Isoenzyme-directed selection and characterization of anti-creatine kinase single chain Fv antibodies from a human phage display library.

scientific article

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

scientific journal article

Ligand control of interaction in vivo between ecdysteroid receptor and ultraspiracle ligand-binding domain.

scientific article published on March 2004

Macro Ck2 Accumulation in Tenofovir-Treated HIV Patients is Facilitated by Ck Oligomer Stabilization but is Not Predictive for Pathology ⬇️

scientific article published on August 16, 2012

Macroenzyme creatine kinase (CK) type 2 in HIV-infected patients is significantly associated with TDF and consists of ubiquitous mitochondrial CK

scientific article published on 01 January 2006

Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling

scientific article

Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling.

scientific article published on 18 September 2014

Mitochondrial NM23-H4/NDPk-D is multifunctional: fueling mitochondrial GTPase OPA1 and triggering mitophagy

abstract published in 2015

Mitochondrial Proteolipid Complexes of Creatine Kinase.

scientific article published in January 2018

Mitochondrial cardiolipin/phospholipid trafficking: the role of membrane contact site complexes and lipid transfer proteins

scientific article published on 26 December 2013

Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium

scientific article (publication date: 21 December 2001)

Mitochondrial kinases and their molecular interaction with cardiolipin.

scientific article published on 04 May 2009

Modelling in vivo creatine/phosphocreatine in vitro reveals divergent adaptations in human muscle mitochondrial respiratory control by ADP after acute and chronic exercise

scientific article published on 3 December 2015

Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation.

scientific article

Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands

scientific article published on 28 September 2006

Monocarboxylate transporters and mitochondrial creatine kinase protein content in McArdle disease.

scientific article published on 19 January 2013

Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

scientific article published on 21 September 2017

Mutation of conserved active-site threonine residues in creatine kinase affects autophosphorylation and enzyme kinetics

scientific article published on May 2002

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

journal article published in 2016

NME4/nucleoside diphosphate kinase D in cardiolipin signaling and mitophagy

scientific article published on 16 October 2017

New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinases.

scientific article

New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics.

scientific article published on August 2006

Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes

scientific article

Octamer-dimer Transitions of Mitochondrial Creatine Kinase in Heart Disease

scientific article published on 01 April 1999

Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: implications for cellular function and mitochondrial structure.

scientific article published in July 1998

Oxidative phosphorylation and its coupling to mitochondrial creatine and adenylate kinases in human gastric mucosa

scientific article published on 01 June 2006

Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects

scientific article

Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma.

scientific article published on 13 May 2008

Proteolipid domains form in biomimetic and cardiac mitochondrial vesicles and are regulated by cardiolipin concentration but not monolyso-cardiolipin

scientific article published on 29 August 2018

Regulation of brain-type creatine kinase by AMP-activated protein kinase: interaction, phosphorylation and ER localization

scientific article published on 12 April 2014

Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome ⬇️

scientific article published on 04 January 2012

Restrictions in ATP diffusion within sarcomeres can provoke ATP-depleted zones impairing exercise capacity in chronic obstructive pulmonary disease.

scientific article published on 26 April 2016

Resveratrol inhibits lipogenesis of 3T3-L1 and SGBS cells by inhibition of insulin signaling and mitochondrial mass increase

scientific article published on 08 March 2016

Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice

scientific article published on 18 October 2021

Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells.

scientific article published on 17 November 2016

Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology.

scientific article

Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins.

scientific article published on 2 November 2005

Structural Properties of AMP-activated Protein Kinase

scientific article published in Journal of Biological Chemistry

Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism

scientific article published on 04 March 2019

The NDPK/NME superfamily: state of the art.

scientific article published in February 2018

The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation

article

The advantage of channeling nucleotides for very processive functions

scientific article

The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches.

scientific article published on January 2007

The creatine kinase system and pleiotropic effects of creatine ⬇️

scientific article published on March 30, 2011

The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage

scientific article published on 29 April 2016

The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis.

scientific article published on 28 February 2018

The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

scientific article published on 21 October 2021

The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration.

scientific article

Vacuolar morphology and cell cycle distribution are modified by leucine limitation in auxotrophic Saccharomyces cerevisiae

scientific article published on 01 December 2000

Where Have the Fluxes Gone? ⬇️

scientific article published on December 24, 2010

Yeast two-hybrid, a powerful tool for systems biology

scientific article

Yeast-based production and purification of HIS-tagged human ATAD3A, A specific target of S100B

scientific article published on 21 April 2012

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