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List of works by Guenther Hochhaus

A Systematic Analysis of the Sensitivity of Plasma Pharmacokinetics to Detect Differences in the Pulmonary Performance of Inhaled Fluticasone Propionate Products Using a Model-Based Simulation Approach

scientific article published on 2 May 2015

A biotin-avidin-based enzyme immunoassay for beta h-endorphin

scientific article

A new fluorogenic assay for tyrosine-containing peptides

scientific article published on 01 January 1991

A new solution-based intranasal triamcinolone acetonide formulation in patients with perennial allergic rhinitis: how does the pharmacokinetic/pharmacodynamic profile for cortisol suppression compare with an aqueous suspension-based formulation?

scientific article published on June 2002

A novel method for polymer coating of plasmid DNA: initial investigations into the use of pulse laser deposition and gene delivery

scientific article published in May 2004

A pharmacokinetic simulation tool for inhaled corticosteroids.

scientific article

A pharmacokinetic/pharmacodynamic approach to predict the cumulative cortisol suppression of inhaled corticosteroids

scientific article published in April 1999

A selective HPLC/RIA for the determination of budesonide

scientific article published on 01 September 1998

A selective LC/RIA for dexamethasone and its prodrug dexamethasone-21-isonicotinate in biological fluids

scientific article published in January 1991

A sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma

scientific article published in February 2000

A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of mometasone furoate in human plasma

scientific article

A sensitivity analysis of the modified chi-square ratio statistic for equivalence testing of aerodynamic particle size distribution.

scientific article published on 24 January 2013

A stability analysis of a modified version of the chi-square ratio statistic: implications for equivalence testing of aerodynamic particle size distribution.

scientific article

Advances in single-entity inhaled corticosteroid therapy.

scientific article published on March 2007

Affinities of glucocorticoids for glucocorticoid receptors in the human lung

scientific article published on 01 January 1986

Age effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats

scientific article published on 03 March 2004

An HPLC/RIA method for dynorphin A1-13 and its main metabolites in human blood

scientific article published on 01 September 1997

An avidin-biotin based enzyme-linked immunosorbent assay for dynorphin A 1-13

scientific article published on 01 January 1990

Analysis of leucine enkephalin by high-performance liquid chromatography using enzymatic derivatization by tyrosinase and electrochemical or fluorescence detection

scientific article published on 01 May 1999

Application of the modified chi-square ratio statistic in a stepwise procedure for cascade impactor equivalence testing.

scientific article published on 17 December 2014

Assessment of complex peptide degradation pathways via structured multicompartmental modeling approaches: the metabolism of dynorphin A1-13 and related fragments in human plasma.

scientific article published in September 1999

Assessment of glucocorticoid lung targeting by ex-vivo receptor binding studies in rats

scientific article published on 01 January 1995

Binding affinities of rimexolone (ORG 6216), flunisolide and their putative metabolites for the glucocorticoid receptor of human synovial tissue

scientific article published in June 1990

Bioequivalence of inhaled drugs: fundamentals, challenges and perspectives.

scientific article published on March 2013

Budesonide and ciclesonide: effect of tissue binding on pulmonary receptor binding.

scientific article

Budesonide in previously untreated autoimmune hepatitis.

scientific article

Characterization of a dextran-budesonide prodrug for inhalation therapy

scientific article published on 04 December 2018

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.

scientific article published on 14 July 2015

Chronic blockade of hindbrain glucocorticoid receptors reduces blood pressure responses to novel stress and attenuates adaptation to repeated stress

scientific article published on 11 March 2009

Comparative pharmacology, bioavailability, pharmacokinetics, and pharmacodynamics of inhaled glucocorticosteroids.

scientific article

Contrary to adult, neonatal rats show pronounced brain uptake of corticosteroids.

scientific article published on 28 February 2006

Current Scientific and Regulatory Approaches for Development of Orally Inhaled and Nasal Drug Products: Overview of the IPAC-RS/University of Florida Orlando Inhalation Conference.

scientific article published on 2 June 2015

Delta opioid receptors in human neuroblastoma cell lines.

scientific article published in September 1986

Dependency of Cortisol Suppression on the Administration Time of Inhaled Corticosteroids

scientific article published on 01 August 1997

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Detection and Quantification of Flunisolide in Tissue Culture Medium

article

Development of a placebo effect model combined with a dropout model for bipolar disorder ⬇️

scientific article published on March 2, 2013

Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids.

scientific article published on March 2006

Do intensive care patients need an individualized dosing regimen for levofloxacin?

scientific article published on 01 June 2006

Drugs used in the treatment of opioid tolerance and physical dependence: a review.

scientific article published on April 2004

Effect of dose and release rate on pulmonary targeting of liposomal triamcinolone acetonide phosphate

scientific article published on 01 March 1998

Effects of lipid formulations on clove extract spray dried powders: comparison of physicochemical properties, storage stability and in vitro intestinal permeation

scientific article published on 19 April 2017

Equivalence considerations for orally inhaled products for local action-ISAM/IPAC-RS European Workshop report

scientific article published on 13 March 2012

Evaluation of the Transwell System for Characterization of Dissolution Behavior of Inhalation Drugs: Effects of Membrane and Surfactant.

scientific article published on 9 July 2015

Evaluation of the administration time effect on the cumulative cortisol suppression and cumulative lymphocytes suppression for once-daily inhaled corticosteroids: a population modeling/simulation approach.

scientific article published in September 2008

Evolution of pharmacokinetics and pharmacokinetic/dynamic correlations during the 20th century

scientific article published on September 2000

HPLC determination of glucocorticoid alcohols, their phosphates and hydrocortisone in aqueous solutions and biological fluids

scientific article published on 01 January 1986

How the lung handles drugs: pharmacokinetics and pharmacodynamics of inhaled corticosteroids.

scientific article

Identification of glucocorticoid receptors in normal and neoplastic adult human lung

scientific article published on 01 January 1983

Identification of stabilized dynorphin derivatives for suppressing tolerance in morphine-dependent rats.

scientific article published in August 2004

In vitro deposition of fluticasone aerosol from a metered-dose inhaler with and without two common valved holding chambers.

scientific article published in February 2002

In vitro performance of two common valved holding chambers with a chlorofluorocarbon-free beclomethasone metered-dose inhaler.

scientific article published in December 2003

Interpretation of absorption rate data for inhaled fluticasone propionate obtained in compartmental pharmacokinetic modeling.

scientific article

Intranasal loteprednol etabonate in healthy male subjects: pharmacokinetics and effects on endogenous cortisol

scientific article published in May 2004

Leucine enkephalin-tyrosinase reaction products--identification and biological activity

scientific article published in May 1994

Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways

scientific article published on 01 May 2000

Lung bioavailability of hydrofluoroalkane fluticasone in young children when delivered by an antistatic chamber/mask.

scientific article published in December 2006

Metabolism of dynorphin A 1-13 in human blood and plasma.

scientific article published on August 1995

Metabolism of dynorphin A1-13 in human CSF.

scientific article published on October 1996

Methods used to assess pulmonary deposition and absorption of drugs

scientific article published on 01 April 2001

New developments in corticosteroids.

scientific article

Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration ⬇️

scientific article published on November 9, 2011

Nonpeptide somatostatin receptor agonists specifically target ocular neovascularization via the somatostatin type 2 receptor.

scientific article

Performance of a corticosteroid inhaler with a spacer fashioned from a plastic cold-drink bottle: effects of changing bottle volume

scientific article

Pharmacodynamics of omalizumab: implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma

scientific article published on January 2003

Pharmacokinetic and pharmacodynamic evaluation of fluticasone propionate after inhaled administration.

scientific article published in February 1998

Pharmacokinetic and pharmacodynamic evaluation of triamcinolone acetonide after intravenous, oral, and inhaled administration

scientific article published on 01 December 1995

Pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs

scientific article published on December 1, 1992

Pharmacokinetic evaluation of visnagin and Ammi visnaga aqueous extract after oral administration in rats

scientific article published on 24 October 2012

Pharmacokinetic/Pharmacodynamic Evaluation of Systemic Effects of Flunisolide after Inhalation

scientific article published on 01 October 1997

Pharmacokinetic/dynamic correlation of pulmonary and cardiac effects of fenoterol in asthmatic patients after different routes of administration

scientific article published in March 1992

Pharmacokinetic/pharmacodynamic aspects of aerosol therapy using glucocorticoids as a model

scientific article published on 01 October 1997

Pharmacokinetic/pharmacodynamic evaluation of inhalation drugs: application to targeted pulmonary delivery systems.

scientific article

Pharmacokinetic/pharmacodynamic profile of mometasone furoate nasal spray: potential effects on clinical safety and efficacy.

scientific article published on January 2008

Pharmacokinetics and pharmacodynamics of dexamethasone sodium-m-sulfobenzoate (DS) after intravenous and intramuscular administration: a comparison with dexamethasone phosphate (DP).

scientific article published in April 2001

Pharmacokinetics and pharmacodynamics of glycopyrrolate following a continuous‐rate infusion in the horse ⬇️

scientific article published on July 31, 2013

Pharmacokinetics and pharmacodynamics of inhaled glucocorticoids.

scientific article published in January 2008

Pharmacokinetics and rectal bioavailability of hydrocortisone acetate after single and multiple administration in healthy subjects and patients

scientific article published in May 2001

Pharmacokinetics of Orally Inhaled Drug Products.

scientific article published on 12 March 2015

Pharmacokinetics of intravenous dynorphin A(1-13) in opioid-naive and opioid-treated human volunteers.

scientific article published in July 1998

Pharmacokinetics of methylprednisolone and prednisolone after single and multiple oral administration

scientific article published on 01 October 1997

Pharmacokinetics of plasmid DNA in the rat.

scientific article

Pharmacokinetics of the dietary supplement creatine.

scientific article

Pharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administration

scientific article published on 01 March 1995

Plasma concentrations of inhaled corticosteroids in relation to airflow obstruction in asthma.

scientific article published in October 2006

Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.

scientific article published on 11 November 2013

Population pharmacokinetics and pharmacodynamics of ciclesonide.

scientific article published in April 2003

Predicting Pulmonary Pharmacokinetics from In Vitro Properties of Dry Powder Inhalers.

scientific article published on 10 August 2017

Pulmonary targeting of liposomal triamcinolone acetonide phosphate

scientific article published on 01 November 1996

Pulmonary targeting of sustained release formulation of budesonide in neonatal rats

scientific article published in December 2006

Quantitative characterization of circadian rhythm of pulmonary function in asthmatic patients treated with inhaled corticosteroids

scientific article

Receptor-based pharmacokinetic-pharmacodynamic analysis of corticosteroids

scientific article published on 01 February 1993

Relative receptor affinity comparisons among inhaled/intranasal corticosteroids: perspectives on clinical relevance.

scientific article

Role of pharmacokinetics in establishing bioequivalence for orally inhaled drug products: workshop summary report.

scientific article published on 31 March 2011

SPE/RIA vs LC/MS for measurement of low levels of budesonide in plasma.

scientific article

Simultaneous determination of glucocorticoid alcohols, their succinates and hydrocortisone in plasma

scientific article published on 01 January 1985

Simultaneous quantification of budesonide and its two metabolites, 6beta-hydroxybudesonide and 16alpha-hydroxyprednisolone, in human plasma by liquid chromatography negative electrospray ionization tandem mass spectrometry.

scientific article

Single- and multiple-dose pharmacokinetics of oral creatine.

scientific article published on January 2003

Single-dose and steady-state pharmacokinetic and pharmacodynamic evaluation of therapeutically clinically equivalent doses of inhaled fluticasone propionate and budesonide, given as Diskus or Turbohaler dry-powder inhalers to healthy subjects

scientific article published in December 2001

Soft drugs--10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etabonate

scientific article

Systemic exposure to fluticasone MDI delivered through antistatic chambers.

scientific article published on 23 July 2011

Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole

scientific article published on 11 August 2009

Validation of a simple liquid chromatography assay for creatine suitable for pharmacokinetic applications, determination of plasma protein binding and verification of percent labeled claim of various creatine products.

scientific article published in August 2003

[Biocytin13]dynorphin A 1-13 amide: a potential probe for the kappa-opioid receptor

scientific article

cAMP accumulation in opioid-sensitive SH-SY5Y neuroblastoma cells is modified by estradiol and progesterone.

scientific article

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