List of works - Sergio D Catz

Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency

scientific article

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

scientific article published on April 2016

Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.

scientific article published on August 2005

Biochemical and morphological changes in the developing kidney.

scientific article published in January 1995

Bradykinin stimulates phosphoinositide turnover and phospholipase C but not phospholipase D and NADPH oxidase in human neutrophils

scientific article published on 01 April 1996

Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells.

scientific article

Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1.

scientific article

Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency

scientific article published on 05 April 2019

Cross-talk between IRAK-4 and the NADPH oxidase.

scientific article published on May 2007

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

scientific article published on 2 May 2017

Decreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome. Comparison with endotoxin and cytokine effects on normal cells

scientific article published on 01 April 1994

Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion

scientific article published on 02 January 2013

Editorial: The secrets of secretion

scientific article published in July 2017

Evaluation of the blood components considered as risk predictors in coronary heart disease

scientific article published on 01 January 1993

Gene transfer and expression in human neutrophils. The phox homology domain of p47phox translocates to the plasma membrane but not to the membrane of mature phagosomes

scientific article

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.

scientific article

Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis

scientific article

Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.

scientific article published on 11 December 2017

Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.

scientific article

JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells

scientific article

JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.

scientific article

Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils

scientific article published on 01 March 1994

MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane

scientific article

Modulation of p47 PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase ⬇️

scientific article published on April 18, 2003

Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.

scientific article

Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.

scientific article

Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses

scientific article

Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils

scientific article

Neutrophils: New insights and open questions

scientific article published on 07 December 2018

Nitric oxide synthase inhibitors decrease human polymorphonuclear leukocyte luminol-dependent chemiluminescence

scientific article published on 01 December 1995

Oxidative stress in rodent closed duodenal loop pancreatitis

scientific article published on 01 February 1996

Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes

scientific article published on March 2007

Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis.

scientific article published on 12 October 2016

Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors

scientific article

Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TR

scientific article published on 14 November 2008

The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells.

scientific article

The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.

scientific article published on 30 October 2008

The role of Rab27a in the regulation of neutrophil function.

scientific article published on 04 August 2014

Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis

scientific article

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.

scientific article

List of works by Sergio D Catz

Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.

Biochemical and morphological changes in the developing kidney.

Bradykinin stimulates phosphoinositide turnover and phospholipase C but not phospholipase D and NADPH oxidase in human neutrophils

Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells.

Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1.

Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency

Cross-talk between IRAK-4 and the NADPH oxidase.

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

Decreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome. Comparison with endotoxin and cytokine effects on normal cells

Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion

Editorial: The secrets of secretion

Evaluation of the blood components considered as risk predictors in coronary heart disease

Gene transfer and expression in human neutrophils. The phox homology domain of p47phox translocates to the plasma membrane but not to the membrane of mature phagosomes

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.

Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis

Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.

Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.

JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells

JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.

Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils

MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane

Modulation of p47 PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase ⬇️

Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.

Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.

Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses

Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils

Neutrophils: New insights and open questions

Nitric oxide synthase inhibitors decrease human polymorphonuclear leukocyte luminol-dependent chemiluminescence

Oxidative stress in rodent closed duodenal loop pancreatitis

Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes

Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis.

Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors

Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TR

The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells.

The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.

The role of Rab27a in the regulation of neutrophil function.

Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.