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List of works by George Koob

'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration

scientific article published on 13 January 2007

5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking

scientific article

A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats

scientific article

A Combination of Buprenorphine and Naltrexone Blocks Compulsive Cocaine Intake in Rodents Without Producing Dependence ⬇️

scientific article published on August 8, 2012

A Light in the Darkness: Repetitive Transcranial Magnetic Stimulation (rTMS) to Treat the Hedonic Dysregulation of Addiction

scientific article published on 12 November 2019

A Phase 2, Double-Blind, Placebo-Controlled Randomized Trial Assessing the Efficacy of ABT-436, a Novel V1b Receptor Antagonist, for Alcohol Dependence

scientific article published on 23 September 2016

A catechol-O-methyltransferase that is essential for auditory function in mice and humans

scientific article

A critical evaluation of a nicotine vaccine within a self-administration behavioral model

scientific article published in April 2010

A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats ⬇️

scientific article published on September 25, 2012

A key role for corticotropin-releasing factor in alcohol dependence

scientific article published on 16 July 2007

A molecular link between the active component of marijuana and Alzheimer's disease pathology

scientific article

A new nomenclature for classifying psychotropic drugs

scientific article

A role for GABA in alcohol dependence

scientific article published on 01 January 2006

A role for GABA mechanisms in the motivational effects of alcohol

scientific article published in October 2004

A role for brain stress systems in addiction

scientific article

A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions

scientific article published on April 2009

A vaccine strategy that induces protective immunity against heroin

scientific article

AAVrh.10-Mediated Expression of an Anti-Cocaine Antibody Mediates Persistent Passive Immunization That Suppresses Cocaine-Induced Behavior ⬇️

scientific article published on May 1, 2012

Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats

scientific article

Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis

scientific article

Acutely administered ethanol participates in testosterone synthesis and increases testosterone in rat brain

scientific article published in January 2003

Addiction and stress: An allostatic view

scientific article published on 15 September 2018

Addiction and the brain antireward system

scientific article published on January 2008

Addiction as a stress surfeit disorder.

scientific article published on 06 June 2013

Addiction is a Reward Deficit and Stress Surfeit Disorder ⬇️

scientific article published on January 1, 2013

Addictions NeuroImaging Assessment (ANIA): towards an integrative framework for alcohol use disorder

scientific article published on 13 April 2020

Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders

scientific article

Addictions Neuroclinical Assessment: A reverse translational approach

scientific article

Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter.

scientific article published on 10 May 2013

Advances in the pharmacotherapy of alcoholism: challenging misconceptions

scientific article published in February 2006

Age, Alcohol Use, and Brain Function: Yoda Says, "With Age and Alcohol, Confused Is the Force"

scientific article published on 01 May 2018

Alcohol dependence as a chronic pain disorder ⬇️

scientific article published on September 11, 2012

Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state

scientific article published on October 2008

Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework

scientific article published on 24 June 2019

Alcohol use disorders: tracts, twins, and trajectories

scientific article

Alcohol-related genes: contributions from studies with genetically engineered mice

scientific article published on September 2006

Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis

scientific article published on January 2008

Alcoholism: allostasis and beyond

scientific article

Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems

scientific article published on 12 November 2011

Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism

scientific article

Allostatic view of motivation: implications for psychopathology.

scientific article published on January 2004

Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access

scientific article published on 24 October 2007

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley ⬇️

scientific article published on 07 December 2012

An Examination of Child and Adolescent Neurodevelopment Through National Institutes of Health Studies

scientific article published on 22 January 2020

Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou

scientific article published on 22 February 2018

Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology

scientific article

Animal models of psychiatric disorders

scientific article published on January 2012

Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence

scientific article

Anti-Cocaine Vaccine Based on Coupling a Cocaine Analog to a Disrupted Adenovirus ⬇️

scientific article published on December 1, 2011

Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol

scientific article published on 3 March 2007

Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats.

scientific article

Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction

scientific article published on 3 January 2017

Anxiolytic-Like Effects of Antisauvagine-30 in Mice Are Not Mediated by CRF2 Receptors ⬇️

scientific article published on August 28, 2013

Application of experimental stressors in laboratory rodents

scientific article published on February 2006

Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.

scientific article published on 4 December 2017

BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice.

scientific article published on 30 December 2013

Basic science: Bedrock of progress

scientific article published on March 2016

Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell

scientific article published on March 2013

Being partial to psychostimulant addiction therapy

scientific article

Biomarkers in substance use disorders

scientific article published on 18 March 2015

Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice

scientific article published on 13 February 2020

Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects

scientific article published on 17 January 2018

Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement ⬇️

scientific article published on January 25, 2002

Brain disease model of addiction: why is it so controversial?

scientific article

Brain pathways to recovery from alcohol dependence

scientific article published on 14 May 2015

Brain stress systems in the amygdala and addiction

scientific article published on 28 March 2009

Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats

scientific article

CRF system recruitment mediates dark side of compulsive eating

scientific article

CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats

scientific article

CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

scholarly article

Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats.

scientific article published in October 2004

Cellular and behavioral interactions of gabapentin with alcohol dependence

scientific article published on May 2008

Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake.

scientific article

Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia

scientific article

Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens

scientific article

Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking

scientific article

Chronic opioid exposure produces increased heroin self-administration in rats

scientific article

Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs

scientific article

Cocaine's long run.

scientific article published in April 2004

Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents

article

Compulsive-Like Sufentanil Vapor Self-Administration in Rats.

scientific article published on 16 August 2017

Compulsive-like responding for opioid analgesics in rats with extended access

scientific article published on 25 July 2014

Conditioned facilitation of brain reward function after repeated cocaine administration ⬇️

scientific article published on October 1, 2003

Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle

scientific article published in August 2002

Conditioned withdrawal drives heroin consumption and decreases reward sensitivity.

scientific article published in May 2006

Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons

scientific article published on 30 June 2006

Control of craving by the prefrontal cortex.

scientific article published on 4 March 2013

Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency

scientific article published on 27 August 2019

Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats

scientific article

Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence.

scientific article

Corticotropin releasing factor: a key role in the neurobiology of addiction

scientific article

Corticotropin-Releasing Factor From Rodents to Primates: Translational Hope Expresses Itself, Pun Intended

scientific article published in September 2016

Corticotropin-releasing factor (CRF) and α2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats ⬇️

scientific article published on April 16, 2013

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats

scientific article

Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation.

scientific article published on 5 August 2004

Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats.

scientific article published in November 2006

Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism

scholarly article

Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats

scientific article published on April 2009

Craving, context and the cortex.

scientific article published on April 2011

Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval

scientific article published on 04 October 2006

Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol

scientific article published on November 2005

Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout

scientific article

Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding

scientific article published on 25 March 2019

Developing a Vaccine Against Multiple Psychoactive Targets: A Case Study of Heroin ⬇️

scientific article published on December 1, 2011

Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by CRF1 receptor antagonism ⬇️

scientific article published on November 23, 2011

Development of pharmacotherapies for drug addiction: a Rosetta stone approach

scientific article published on June 2009

Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction

scientific article published on 6 April 2006

Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity.

scientific article published on 21 December 2012

Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal.

scientific article

Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats.

scientific article published on 18 October 2006

Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats

scientific article

Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome

scientific article

Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats

scientific article published on 14 September 2007

Drug addiction: pathways to the disease and pathophysiological perspectives

scientific article published on 12 December 2006

Drug specificity in extended access cocaine and heroin self-administration.

scientific article

Dynamic vaccine blocks relapse to compulsive intake of heroin ⬇️

scientific article published on May 6, 2013

Dynorphin, Dysphoria, and Dependence: the Stress of Addiction

scientific article

Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking

scientific article

ERK regulation in chronic ethanol exposure and withdrawal

scientific article published in September 2002

Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration

scientific article published on 28 February 2007

Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats

scientific article published on 10 July 2008

Effects of Naltrexone Alone and In Combination With Acamprosate on the Alcohol Deprivation Effect in Rats ⬇️

scientific article published on April 9, 2003

Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.

scientific article

Effects of dose and session duration on cocaine self-administration in rats

scientific article published on 3 January 2007

Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats

scientific article published on February 2008

Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat.

scientific article published in March 2006

Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats.

scientific article

Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats.

scientific article

Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects

scientific article published on 4 December 2012

Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure

scientific article published in November 2004

Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats

scientific article published on 5 March 2018

Epilepsy, CNS viral injury and dynorphin

scientific article published on February 2004

Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels.

scientific article

Escalation of drug self-administration as a hallmark of persistent addiction liability

scientific article published on September 2013

Escalation of methamphetamine self-administration in rats: a dose-effect function

scientific article published on 17 March 2006

Escalation patterns of varying periods of heroin access.

scientific article

Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence

scientific article published on 26 June 2018

Ethanol, endocannabinoids, and the cannabinoidergic signaling system

scientific article published in April 2002

Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats

scientific article published in January 2004

Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism

scientific article published on 15 February 2018

Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol‐dependent rats ⬇️

scientific article published on February 11, 2011

Existing and Future Drugs for the Treatment of the Dark Side of Addiction

scientific article

Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, an Overview ⬇️

scientific article published on January 1, 2012

Exposure to chronic intermittent nicotine vapor induces nicotine dependence

scientific article

Extended access cocaine self‐administration differentially activates dorsal raphe and amygdala corticotropin‐releasing factor systems in rats ⬇️

scientific article published on July 18, 2011

Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus

scientific article

Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments.

scientific article

Extended access to nicotine leads to a CRF1receptor dependent increase in anxiety-like behavior and hyperalgesia in rats ⬇️

scientific article published on July 22, 2013

Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats

scientific article published on 18 October 2006

Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine

scientific article

First Congress of "Alcoholism and stress: a framework for future treatment strategies": Introduction to the proceeding

scientific article published in November 2009

Focus on: Neuroscience and treatment: the potential of neuroscience to inform treatment ⬇️

scientific article published on January 1, 2010

Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats.

scientific article

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction

scientific article

Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

scientific article

Genetic studies of alcohol dependence in the context of the addiction cycle

scientific article published on 21 January 2017

Genetical genomic determinants of alcohol consumption in rats and humans

scientific article

Ghrelin receptor deletion reduces binge-like alcohol drinking in rats

scientific article published on 16 January 2019

Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals

scientific article

Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior

scientific article

Heroin addiction engages negative emotional learning brain circuits in rats

scientific article published on 26 March 2019

Heterogeneity of alcohol use disorder: understanding mechanisms to advance personalized treatment

scientific article published on 01 April 2015

High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats

scientific article

Hippocampal neurogenesis protects against cocaine‐primed relapse ⬇️

scientific article published on December 24, 2012

Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity

scientific article

Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat.

scientific article published in April 2003

Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide

scientific article (publication date: 5 July 2002)

Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats

scientific article

Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats

scientific article

Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor

scientific article published on January 2013

Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence

scientific article

Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

scientific article published on 2 February 2015

Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats

scientific article

Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection

scientific article published in January 2004

Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor

scientific article published in August 2005

Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency

scientific article published on 25 June 2019

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats

scientific article published on 18 March 2019

Inaugural issue of the journal of addiction medicine

scientific article published in March 2007

Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation

scientific article published on June 2004

Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor

scientific article published in October 2002

Individual differences in prefrontal cortex function and the transition from drug use to drug dependence

scientific article

Individual differences in the neuropsychopathology of addiction

scientific article published in September 2017

Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents.

scientific article published on 3 May 2018

Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats.

scientific article published on 15 July 2002

Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine

scientific article published on 30 May 2009

Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST)

scientific article

Investigations using immunization to attenuate the psychoactive effects of nicotine

scientific article

Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains

scientific article published on 24 June 2014

It is time to take a stand for medical research and against terrorism targeting medical scientists

scientific article

Kappa opioid control of seizures produced by a virus in an animal model

scientific article published on 6 January 2006

Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala

scientific article published on 21 October 2013

Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction

scientific article published on 14 June 2013

Key role for enkephalinergic tone in cortico-striatal-thalamic function

scientific article published on November 2002

Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats

scientific article

Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice.

scientific article published in June 2002

Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice

scientific journal article

Larry Parsons: Researcher, mentor, and friend

scientific article published on 01 November 2018

Larry Stein: pioneer neuropsychopharmacology researcher, mentor, and friend

scientific article published on 09 September 2019

Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat.

scientific article

Levels of Neural Progenitors in the Hippocampus Predict Memory Impairment and Relapse to Drug Seeking as a Function of Excessive Methamphetamine Self-Administration ⬇️

scientific article published on December 28, 2011

Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist

scientific article published on August 2003

Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake

scientific article published on December 2013

Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats

scientific article published in January 2003

MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist

scientific article published on 23 October 2007

Male and female mice develop escalation of heroin intake and dependence following extended access

scientific article published on 14 March 2019

Measuring meals: structure of prandial food and water intake of rats

scientific article published on 6 January 2005

Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake

scientific article

Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats

scientific article published on 16 December 2004

Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis.

scientific article published on October 2007

Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior.

scientific article published in January 2002

Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats

scientific article published in December 2006

Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats

scientific article

Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion

scientific article published on 23 July 2007

Negative reinforcement in drug addiction: the darkness within ⬇️

scientific article published on April 27, 2013

Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction.

scientific article published on 13 June 2014

Neural mechanisms of pain and alcohol dependence

scientific article

Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization

scientific article published in December 2002

Neuroactive steroids: new biomarkers of cognitive aging

scientific article

Neuroadaptive mechanisms of addiction: studies on the extended amygdala

scientific article published on December 2003

Neurobiologic Advances from the Brain Disease Model of Addiction

scientific article

Neurobiological evidence for hedonic allostasis associated with escalating cocaine use.

scientific article

Neurobiological mechanisms in the transition from drug use to drug dependence.

scientific article published on January 2004

Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor.

scientific article

Neurobiological substrates for the dark side of compulsivity in addiction

scientific article published on 07 August 2008

Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement

scientific article published on 12 June 2019

Neurobiology of addiction: a neurocircuitry analysis

scientific article

Neurobiology of alcohol dependence: focus on motivational mechanisms.

scientific article published on January 2008

Neurobiology of dysregulated motivational systems in drug addiction

scientific article

Neurocircuitry of Addiction

Neurocircuitry of addiction

scientific article

Neurocircuitry of alcohol addiction: synthesis from animal models

scientific article

Neuroclinical Framework for the Role of Stress in Addiction

scientific article published on 01 February 2017

Neuroethics for the National Institutes of Health BRAIN Initiative

article

Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder

scientific article published on 04 January 2019

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

scientific article

Neuropeptide S: a novel activating anxiolytic?

scientific article published in August 2004

Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking

scientific article published on 16 April 2008

Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence

scientific article

Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats.

scientific article published on 03 May 2013

Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus

scientific article

Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action

scientific article

Neuroscience of Compulsive Eating Behavior

scientific article published on 24 August 2017

Neurosteroids in learning and memory processes

article

New developments in addiction treatment.

scientific article published on November 2006

New dimensions in human laboratory models of addiction

scientific article

Nibbling at CRF receptor control of feeding and gastrocolonic motility

scientific article

Nicotine withdrawal in adolescent and adult rats

scientific article published in June 2004

Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects

scientific article

Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats

scientific article published on 09 September 2009

Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST).

scientific article published on 6 October 2017

Opioid use disorder

scientific article published on 09 January 2020

Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain

scientific article

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

article

PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease

scientific article published on 20 November 2019

Pathological Overeating: Emerging Evidence for a Compulsivity Construct

scientific article published on 6 December 2016

Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology

scientific article published on 04 April 2019

Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence

scientific article published on 06 June 2009

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

scientific article

Pharmacology, Biochemistry and Behavior: the 2015 transition

scientific article published on 4 February 2015

Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats

scientific article

Plasticity of reward neurocircuitry and the 'dark side' of drug addiction

scientific article

Potential neuroprotective effects of acamprosate

scientific article published in April 2002

Preclinical studies of alcohol binge drinking ⬇️

scientific article published on January 1, 2011

Preclinical validation of a novel cocaine exposure therapy for relapse prevention

scientific article

Preface (New Research Frontiers and Advances in Drug Addiction)

Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder?

scientific article published on 01 January 2019

Probing Active Cocaine Vaccination Performance through Catalytic and Noncatalytic Hapten Design ⬇️

scientific article published on April 29, 2013

Probing the Effects of Hapten Stability on Cocaine Vaccine Immunogenicity ⬇️

scientific article published on 04 October 2013

Probing the protective effects of a conformationally constrained nicotine vaccine ⬇️

scientific article published on September 7, 2012

Progress in corticotropin-releasing factor-1 antagonist development

scientific article

Promoting Wellness in Older Adults with Mental Illnesses and Substance Use Disorders: Call to Action to All Stakeholders

scientific article published on 26 April 2018

Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis

scientific article

Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence.

scientific article published on September 2016

Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking

scientific article

Reduction of anxiety after restricted feeding in the rat: implication for eating disorders

scientific article published in June 2004

Refractory dependence on opioid analgesics

scientific article published on 01 December 2019

Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake".

scientific article published in July 2008

Remembering the forgotten non-communicable diseases

scientific article published on 22 October 2014

Reply to Brewer: Liver-targeted ALDH2 inhibition may reduce alcohol-seeking behaviors with limited side effects

scientific article published on 03 March 2020

Reply to Cohen and Murnion

scientific article published on 01 July 2020

Reply to: Neuroclinical Assessment of Addiction Needs to Incorporate Decision-Making Measures and Ecological Validity

scientific article published on 30 August 2016

Review. Neurobiological mechanisms for opponent motivational processes in addiction

scientific article published on October 2008

Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence.

scientific article

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

scholarly article

Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention

scientific article

Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question

scientific article published in August 2005

Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist

scientific article published on 14 May 2009

Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons

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Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease

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Sex Differences in Animal Models: Focus on Addiction.

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Sex, strain, and estrous cycle influences on alcohol drinking in rats

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Straight talk with...George Koob. Interview by Elie Dolgin

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Stress enhancement of craving during sobriety: a risk for relapse

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Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder

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Stress, dysregulation of drug reward pathways, and the transition to drug dependence

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Structural and compositional determinants of cortistatin activity

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Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use

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Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex.

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Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats

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Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking

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The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection

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The NIH Blueprint for Neuroscience Research Seeks Community Input on Future Neuroscience Investments

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The NK1 receptor antagonist L822429 reduces heroin reinforcement

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The Neurobiology of Addiction: Where We Have Been and Where We Are Going

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The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery ⬇️

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The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration

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The conception of the ABCD study: From substance use to a broad NIH collaboration

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The corticotropin-releasing factor/urocortin system and alcohol

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The dark side of emotion: the addiction perspective

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The dark side of food addiction ⬇️

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The darkness within: individual differences in stress

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The development and maintenance of drug addiction

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The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access

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The future is now: A 2020 view of alcoholism research.

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The future of translational research on alcohol use disorder

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The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats

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The neurobiology of addiction: a neuroadaptational view relevant for diagnosis

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The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse

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The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption

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The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking

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The therapeutic potential of CRF1 antagonists for anxiety

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The transition from controlled to compulsive drug use is associated with a loss of sensitization.

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Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit Disorder ⬇️

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Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol

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Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.

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Treatment of alcohol dependence with drug antagonists of the stress response

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Unlimited access to heroin self-administration: independent motivational markers of opiate dependence

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Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors

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Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior

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VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation.

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Vapor inhalation of alcohol in rats

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Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration

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Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis

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Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats.

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Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization

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What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications

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alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol

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κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake

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