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List of works by Robert Lafyatis

A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists

scientific article published on 01 March 2007

Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis

scientific article published on 26 June 2012

Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion

scientific article published on 01 January 1991

Alternative splicing of the 5' region of cathepsin B pre-messenger RNA in rheumatoid synovial tissue

scientific article published on 01 August 1997

An integrated cell atlas of the lung in health and disease

Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome.

scientific article

Antibodies in rheumatoid synovial fluids bind to a restricted series of protein antigens in rheumatoid synovial tissue

scientific article published on 01 September 1992

Antimalarial agents: closing the gate on Toll-like receptors?

scientific article published on 01 October 2006

Application of Biomarkers to Clinical Trials in Systemic Sclerosis ⬇️

scientific article published on February 1, 2012

Assessment of strategies for identifying diagnosed cases of systemic lupus erythematosus through self-report.

scientific article published on January 2003

B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis

scientific article published on February 2009

B cell infiltration in systemic sclerosis-associated interstitial lung disease

scientific article published on 01 September 2007

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma? ⬇️

scientific article published on June 1, 2011

Capillary regeneration in scleroderma: stem cell therapy reverses phenotype?

scientific article

Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor beta

scientific article published on 13 April 2008

Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats.

scientific article

Connective tissue disease: SSc-fibrosis takes flight with Wingless inhibition.

scientific article published on 3 July 2012

Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis

scientific article published on 24 May 2010

Elevated expression of cav-1 in a subset of SSc fibroblasts contributes to constitutive Alk1/Smad1 activation.

scientific article

Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis.

scientific article published on November 2006

Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis

scientific article published on 01 September 2020

Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions

scientific article published on January 2007

Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering

scientific article published on 01 December 2004

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

scientific article published on October 2010

Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis

scientific journal article

Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension

scientific article

Increased expression of type I collagen induced by microfibril-associated glycoprotein 2: novel mechanistic insights into the molecular basis of dermal fibrosis in scleroderma.

scientific article published on June 2005

Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression

scientific article

Innate immunity and inflammation in systemic sclerosis

scientific article

Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension.

scientific article

Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site

scientific article published on 01 July 1990

Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets

scientific article

Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies.

scientific article published on 9 February 2012

Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury

scientific article

Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3.

scientific article published in May 2002

Myofibroblast transcriptome indicates SFRP2<sup>hi</sup> fibroblast progenitors in systemic sclerosis skin

scientific article published on 19 July 2021

Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis

scientific article

New insights into the mechanisms of innate immune receptor signalling in fibrosis.

scientific article

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation

scientific article published on 04 October 2007

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

scientific article published on 22 August 2019

Regulation of the transforming growth factor-beta 1 and -beta 3 promoters by transcription factor Sp1.

scientific article published in July 1993

Retracted: HLA-B35 and dsRNA Induce Endothelin-1 via Activation of ATF4 in Human Microvascular Endothelial Cells

retracted article

Rituximab: a potential therapeutic advance in scleroderma: what is the evidence?

scientific article published on 23 December 2009

Role for Toll-like receptor 3 in muscle regeneration after cardiotoxin injury

scientific article published on 01 April 2011

Role of aggrecanase 1 in Lyme arthritis.

scientific article

Single-Cell Lymphocyte Heterogeneity in Advanced Cutaneous T-cell Lymphoma Skin Tumors

scientific article published on 22 April 2019

Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis

scientific article published on 10 August 2010

Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1

scientific article published on 01 June 1993

Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors

scientific article

The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts

scientific article

The cytokine language of monocytes and macrophages in systemic sclerosis.

scientific article published on 29 October 2010

The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes

scientific article

The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator.

scientific article published on June 1994

Tofacitinib blocks interferon-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial

scientific article published in 2022

Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma

scientific article published on 7 November 2012

Toll-like receptors and innate immune responses in systemic lupus erythematosus.

scientific article published in January 2007

Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation

scientific article published on 01 November 2002

Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system ⬇️

scientific article published on January 1, 1991

Type I interferons inhibition of inflammatory T helper cell responses in systemic lupus erythematosus.

scientific article published on June 2007

Xerostomia in systemic sclerosis: systematic evaluation by salivary scintigraphy and lip biopsy in thirty-four patients

scientific article published on 01 March 1994

dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts.

scientific article published on 10 November 2010

p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis.

scientific article published on 10 January 2013

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