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List of works by Robert L. Mauck

"Looping In" Mechanics: Mechanobiologic Regulation of the Nucleus and the Epigenome

scientific article published on 14 April 2020

2020, A weird year!

scientific article published on 28 December 2020

A Chemomechanical Model of Matrix and Nuclear Rigidity Regulation of Focal Adhesion Size

scientific article

A common language for evaluating disc degeneration and regeneration: A JOR Spine/ORS Spine Section initiative

scientific article published on 31 May 2019

A high throughput mechanical screening device for cartilage tissue engineering

scientific article

A high-throughput model of post-traumatic osteoarthritis using engineered cartilage tissue analogs

scientific article

A large animal model that recapitulates the spectrum of human intervertebral disc degeneration.

scientific article published on 26 August 2016

A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs.

scientific article published in January 2005

A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading.

scientific article published on January 2004

A radiopaque electrospun scaffold for engineering fibrous musculoskeletal tissues: Scaffold characterization and in vivo applications.

scientific article

Acellular biomaterials: an evolving alternative to cell-based therapies.

scientific article published on March 2013

Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus

scientific article published on 5 April 2016

Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model

article

An anisotropic nanofiber/microsphere composite with controlled release of biomolecules for fibrous tissue engineering.

scientific article

Anatomic Mesenchymal Stem Cell-Based Engineered Cartilage Constructs for Biologic Total Joint Replacement.

scientific article published on February 2016

Anatomically shaped osteochondral constructs for articular cartilage repair.

scientific article published in December 2003

Autologous tendon-derived cell-seeded nanofibrous scaffolds improve rotator cuff repair in an age-dependent fashion

scientific article

Biaxial mechanics and inter‐lamellar shearing of stem‐cell seeded electrospun angle‐ply laminates for annulus fibrosus tissue engineering ⬇️

scientific article published on January 17, 2013

Biodegradable fibrous scaffolds with diverse properties by electrospinning candidates from a combinatorial macromer library

scientific article

Biomaterial-mediated delivery of degradative enzymes to improve meniscus integration and repair

scientific article published on 29 January 2013

Biomaterials in the repair of sports injuries

scientific article published on 24 July 2012

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

scientific article

Biphasic Finite Element Modeling Reconciles Mechanical Properties of Tissue-Engineered Cartilage Constructs Across Testing Platforms

scientific article published on 14 April 2017

Cartilage Matrix Formation by Bovine Mesenchymal Stem Cells in Three-dimensional Culture Is Age-dependent ⬇️

scientific article published on October 1, 2011

Cartilage interstitial fluid load support in unconfined compression following enzymatic digestion.

scientific article published on December 2004

Cartilage mechanical response under dynamic compression at physiological stress levels following collagenase digestion.

scientific article published on 12 January 2008

Cartilage repair and subchondral bone remodeling in response to focal lesions in a mini-pig model: implications for tissue engineering.

scientific article

Cationic gadolinium chelate for magnetic resonance imaging of cartilaginous defects

scientific article published on 08 February 2016

Cell migration: implications for repair and regeneration in joint disease

scientific article published on 01 March 2019

Cell therapy for the degenerating intervertebral disc

scientific article published on 28 November 2016

Chondrocyte translocation response to direct current electric fields.

scientific article published on June 2000

Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture.

scientific article published on 27 October 2005

Coculture of Human Mesenchymal Stem Cells and Articular Chondrocytes Reduces Hypertrophy and Enhances Functional Properties of Engineered Cartilage ⬇️

scientific article published on January 8, 2011

Correlations between quantitative T2 and T1ρ MRI, mechanical properties and biochemical composition in a rabbit lumbar intervertebral disc degeneration model.

scientific article

Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells.

scientific article published on 8 December 2016

Cross-Linking Chemistry of Tyramine-Modified Hyaluronan Hydrogels Alters Mesenchymal Stem Cell Early Attachment and Behavior

scientific article published in February 2017

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells.

scientific article published on June 2015

Development of a Large Animal Model of Osteochondritis Dissecans of the Knee: A Pilot Study.

scientific article

Differential behavior of auricular and articular chondrocytes in hyaluronic acid hydrogels.

scientific article published in July 2008

Differential maturation and structure-function relationships in mesenchymal stem cell- and chondrocyte-seeded hydrogels

scientific article

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

scientific article

Difficult times!

scientific article published on 23 June 2020

Dose and Timing of N-Cadherin Mimetic Peptides Regulate MSC Chondrogenesis within Hydrogels.

scientific article

Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage

scientific article

Dynamic Compressive Loading Enhances Cartilage Matrix Synthesis and Distribution and Suppresses Hypertrophy in hMSC-Laden Hyaluronic Acid Hydrogels ⬇️

scientific article published on December 2, 2011

Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds.

scientific article published on 20 August 2010

Dynamic deformational loading results in selective application of mechanical stimulation in a layered, tissue-engineered cartilage construct.

scientific article published in January 2006

Editorial. The mechanical behaviour of cells, tissues and biomaterials

scientific article published on 01 October 2014

Effect of overuse-induced tendinopathy on tendon healing in a rat supraspinatus repair model.

scientific article published on 27 July 2015

Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model

scientific article published on 28 December 2015

Electrospinning of photocrosslinked and degradable fibrous scaffolds

scientific article

Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation.

scientific article

Engineered disc-like angle-ply structures for intervertebral disc replacement.

scientific article

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

scientific article published on 26 February 2015

Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration.

scientific article

Enhanced MSC chondrogenesis following delivery of TGF-β3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo ⬇️

scientific article published on June 8, 2011

Enhanced nutrient transport improves the depth-dependent properties of tri-layered engineered cartilage constructs with zonal co-culture of chondrocytes and MSCs

scientific article published on 16 June 2017

Evaluation of the complex transcriptional topography of mesenchymal stem cell chondrogenesis for cartilage tissue engineering.

scientific article

Expansion of mesenchymal stem cells on electrospun scaffolds maintains stemness, mechano-responsivity, and differentiation potential

scientific article published on 13 October 2017

Fabrication and evaluation of biomimetic-synthetic nanofibrous composites for soft tissue regeneration

article

Fabrication and maturation of integrated biphasic anatomic MSC-laden composite scaffolds for osteochondral repair and joint resurfacing

scientific article published on 24 December 2020

Fabrication and modeling of dynamic multipolymer nanofibrous scaffolds

scientific article

Fiber Stretch and Reorientation Modulates Mesenchymal Stem Cell Morphology and Fibrous Gene Expression on Oriented Nanofibrous Microenvironments ⬇️

scientific article published on July 29, 2011

Fiber angle and aspect ratio influence the shear mechanics of oriented electrospun nanofibrous scaffolds

scientific article published on 23 March 2011

Fibrous Scaffolds with Varied Fiber Chemistry and Growth Factor Delivery Promote Repair in a Porcine Cartilage Defect Model.

scientific article

From repair to regeneration: biomaterials to reprogram the meniscus wound microenvironment.

scientific article

Functional consequences of glucose and oxygen deprivation on engineered mesenchymal stem cell-based cartilage constructs.

scientific article

Functional properties of bone marrow-derived MSC-based engineered cartilage are unstable with very long-term in vitro culture.

scientific article published on 22 October 2013

Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels

scientific article published on 01 June 2000

Functional tissue engineering of chondral and osteochondral constructs

scientific article published in January 2004

Future of spine research: "The Asian perspectives"

scientific article published on 27 June 2018

Growth factor supplementation improves native and engineered meniscus repair in vitro

scientific article

High fidelity visualization of cell-to-cell variation and temporal dynamics in nascent extracellular matrix formation.

scientific article

High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties.

scientific article

High-throughput screening for modulators of mesenchymal stem cell chondrogenesis

scientific article

High-throughput screening of a small molecule library for promoters and inhibitors of mesenchymal stem cell osteogenic differentiation.

scientific article

Homologous structure-function relationships between native fibrocartilage and tissue engineered from MSC-seeded nanofibrous scaffolds

scientific article published on 28 September 2010

Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid.

scientific article

Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long-term agarose culture

scientific article published on 8 March 2015

IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro ⬇️

scientific article published on August 3, 2012

Impact of guidance documents on translational large animal studies of cartilage repair.

scientific article

Improved cartilage repair via in vitro pre-maturation of MSC-seeded hyaluronic acid hydrogels.

scientific article

In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty.

scientific article published on 17 November 2017

In memory of Peter Roughly and John Mort: Time for a "biochemical" reflection

scientific article published on 19 August 2019

In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus.

scientific article

In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model.

scientific article

In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation.

scientific article published on 21 November 2014

Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels

scientific article published on 01 September 2002

Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model.

scientific article published on 31 August 2017

Intervertebral disc development and disease-related genetic polymorphisms

scientific article published on 23 April 2016

JOR Spine: A (first) year in review

scientific article published on 17 December 2018

Large Animal Models of Meniscus Repair and Regeneration: A Systematic Review of the State of the Field

scientific article published on 16 June 2017

Localized delivery of ibuprofen via a bilayer delivery system (BiLDS) for supraspinatus tendon healing in a rat model

scientific article published on 25 March 2020

Low-serum media and dynamic deformational loading in tissue engineering of articular cartilage.

scientific article published on 26 February 2008

Macro- to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific

scientific article

Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels.

scientific article published on 15 July 2009

Magneto-Driven Gradients of Diamagnetic Objects for Engineering Complex Tissues

scientific article published on 19 October 2020

Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds.

scientific article

Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues.

scientific article published on 19 February 2018

Maturation state-dependent alterations in meniscus integration: implications for scaffold design and tissue engineering

scientific article

Maximizing cartilage formation and integration via a trajectory-based tissue engineering approach.

scientific article published on 04 December 2013

Mechanical function near defects in an aligned nanofiber composite is preserved by inclusion of disorganized layers: Insight into meniscus structure and function

scientific article published on 31 January 2017

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells.

scientific article

Mechano-topographic modulation of stem cell nuclear shape on nanofibrous scaffolds

scientific article

Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix.

scientific article published on 24 February 2017

Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage

scientific article published on 4 January 2016

Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization

scientific article published on 01 January 2000

Modeling interlamellar interactions in angle-ply biologic laminates for annulus fibrosus tissue engineering

scientific article

Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering.

scientific article

Multi-scale structural and tensile mechanical response of annulus fibrosus to osmotic loading

scientific article

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells.

scientific article published on 15 August 2016

Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs.

scientific article published on 11 April 2017

New year, new initiatives!

scientific article published on 08 March 2019

On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis.

scientific article published on 27 October 2017

Organized nanofibrous scaffolds that mimic the macroscopic and microscopic architecture of the knee meniscus.

scientific article

Osteocyte viability and regulation of osteoblast function in a 3D trabecular bone explant under dynamic hydrostatic pressure.

scientific article published in June 2004

Pathogenesis and prevention of posttraumatic osteoarthritis after intra-articular fracture

scientific article

Pediatric laryngotracheal reconstruction with tissue-engineered cartilage in a rabbit model.

scientific article

Phenotypic stability, matrix elaboration and functional maturation of nucleus pulposus cells encapsulated in photocrosslinkable hyaluronic acid hydrogels.

scientific article

Porosity and cell preseeding influence electrospun scaffold maturation and meniscus integration in vitro.

scientific article published on 30 November 2012

Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair.

scientific article published on 24 November 2017

Promise, progress, and problems in whole disc tissue engineering

scientific article published on 23 May 2018

Protocols, new ARB members, and Awards!

scientific article published on 29 September 2020

Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair.

scientific article published in January 2007

Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading.

scientific article published on 12 May 2006

Repair of dense connective tissues via biomaterial-mediated matrix reprogramming of the wound interface

scientific article

Restoration of physiologic loading modulates engineered intervertebral disc structure and function in an in vivo model

scientific article published on 13 May 2020

Role of cell-associated matrix in the development of free-swelling and dynamically loaded chondrocyte-seeded agarose gels

scientific article published in January 2004

Role of dexamethasone in the long-term functional maturation of MSC-laden hyaluronic acid hydrogels for cartilage tissue engineering.

scientific article published on 27 November 2017

Sacrificial nanofibrous composites provide instruction without impediment and enable functional tissue formation ⬇️

scientific article published on August 7, 2012

Single Cell Imaging to Probe Mesenchymal Stem Cell N-Cadherin Mediated Signaling within Hydrogels.

scientific article published on 22 April 2016

Single-cell differences in matrix gene expression do not predict matrix deposition.

scientific article published on 3 March 2016

Spatial distribution of type II collagen gene expression in the mouse intervertebral disc

scientific article published on 19 December 2019

Starting with form, emerging with function: nanofibrous scaffolds for tissue engineering of orthopedic tissues

scientific article published on 01 April 2013

Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

scientific article

Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering.

scientific article published in August 2003

T1rho Magnetic Resonance Imaging at 3T Detects Knee Cartilage Changes After Viscosupplementation.

scientific article published on July 2015

The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction

scientific article published on 3 December 2016

The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3.

scientific article published on 10 May 2007

The detrimental effects of systemic Ibuprofen delivery on tendon healing are time-dependent

scientific article

The effect of applied compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3.

scientific article published in January 2006

The effect of nanofiber alignment on the maturation of engineered meniscus constructs.

scientific article published on 23 January 2007

The influence of an aligned nanofibrous topography on human mesenchymal stem cell fibrochondrogenesis.

scientific article

The influence of fibrous elastomer structure and porosity on matrix organization

scientific article

The influence of hyaluronic acid hydrogel crosslinking density and macromolecular diffusivity on human MSC chondrogenesis and hypertrophy ⬇️

scientific article published on October 22, 2012

The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers.

scientific article published on 3 March 2008

The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading.

scientific article published in December 2003

Time-dependent aggrecan gene expression of articular chondrocytes in response to hyperosmotic loading

scientific article published on 01 November 2001

Time-dependent functional maturation of scaffold-free cartilage tissue analogs.

scientific article published on 22 October 2013

Tissue engineering and regenerative medicine: recent innovations and the transition to translation.

scientific article published on February 2013

To Serve and Protect: Hydrogels to Improve Stem Cell-Based Therapies

scientific article published in January 2016

Towards the Scale up of Tissue Engineered Intervertebral Discs for Clinical Application.

scientific article published on 7 February 2018

Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner.

scientific article

Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage

scientific article

Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model.

scientific article

Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model.

scientific article

Welcome to JOR Spine!

scientific article published on 24 March 2018

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