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List of works by Trevor Sharp

5-HT and depression: is the glass half-full? ⬇️

scientific article published on February 2011

5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis.

scientific article published on February 1989

A Model of Post-Infection Fatigue Is Associated with Increased TNF and 5-HT2A Receptor Expression in Mice

scientific article (publication date: 2015)

A combined in vivo neurochemical and electrophysiological analysis of the effect of high-frequency stimulation of the subthalamic nucleus on 5-HT transmission

scientific article published on 8 September 2011

A manually-operated brain tissue slicer suitable for neurotransmitter release studies

scientific article published on 01 February 1983

A review of central 5-HT receptors and their function

scientific article (publication date: August 1999)

A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control

scientific article published in June 2005

A safe lithium mimetic for bipolar disorder

scientific article

Activation of 5-HT(6) receptors facilitates attentional set shifting

scientific article published on 10 November 2009

Affinity of (+/-)-pindolol, (-)-penbutolol, and (-)-tertatolol for pre- and postsynaptic serotonin 5-HT(1A) receptors in human and rat brain

scientific article published on 01 August 2000

An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat ⬇️

scientific article published on November 1, 1998

An investigation of the origin of extracellular GABA in rat nucleus accumbens measured in vivo by microdialysis

scientific article published on 01 January 1994

Analeptic effects of centrally injected TRH and analogues of TRH in the pentobarbitone-anaesthetized rat.

scientific article published on March 1984

Antidepressant drug treatment induces Arc gene expression in the rat brain.

scientific article published in January 2003

Application of brain microdialysis to study the pharmacology of the 5-HT1A autoreceptor.

scientific article published on September 1990

Attenuation of some subjective effects of amphetamine following tyrosine depletion.

scientific article published in January 1999

Behavioural and neuroendocrine responses to D-fenfluramine in rats treated with neurotoxic amphetamines

article

Biochemical evidence for the regulation of central noradrenergic activity by 5-HT1A and 5-HT2 receptors: microdialysis studies in the awake and anaesthetized rat.

scientific article

Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: a combined qPCR, in situ hybridisation and immunocytochemistry study

scientific article published on 22 July 2012

Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and resilient rats

scientific article published on 24 July 2010

Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex

scientific journal article

Changes in monoamine metabolites measured by simultaneous in vivo differential pulse voltammetry and intracerebral dialysis

scientific article published in August 1984

Clonidine but not nifedipine prevents the release of noradrenaline during naloxone-precipitated opiate withdrawal: an in vivo microdialysis study in the rat.

scientific article

Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making.

scientific article

Comparison of the effect of buspirone and 1-(2-pyrimidinyl)-piperazine on cerebral glucose utilization in the rat.

scientific article published in January 1993

Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission.

scientific article published on 13 January 2017

Corrigendum to "Systemic inflammation alters central 5-HT function as determined by pharmacological MRI" [Neuroimage 75 (2013) 177-186].

scientific article published on 18 March 2014

Critical issues in the antisense inhibition of brain gene expression in vivo: experiences targetting the 5-HT1A receptor.

scientific article published on September 1997

D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine

scientific article

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice

scientific article

Deep brain stimulation of the nucleus accumbens shell increases impulsive behavior and tissue levels of dopamine and serotonin

scientific article published on 11 July 2010

Determination of dopamine and its metabolites in small volumes of rat brain dialysates using small-bore liquid chromatography with electrochemical detection

scientific article published on 01 October 1986

Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors.

scientific article

Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1.

scientific article published on 13 November 2010

Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort.

scientific article published on 10 December 2004

Differential pulse voltammetry in vivo--evidence that uric acid contributes to the indole oxidation peak

scientific article published in December 1983

Differential pulse voltammetry: simultaneous in vivo measurement of ascorbic acid, catechols and 5-hydroxyindoles in the rat striatum.

scientific article published in November 1984

Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?

scientific article

Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine

scientific article published on 01 October 2000

Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release.

scientific article published in January 1999

Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo

scientific article published on 01 October 1993

Effect of acute tyrosine depletion in using a branched chain amino-acid mixture on dopamine neurotransmission in the rat brain

scientific article published on February 2006

Effect of antidepressant drugs on dopamine D1 and D2 receptor expression and dopamine release in the nucleus accumbens of the rat.

scientific article

Effect of dopamine D-1 and D-2 receptor selective drugs on dopamine release and metabolism in rat striatum in vivo

scientific article

Effect of naloxone-precipitated morphine withdrawal on noradrenaline release in rat hippocampus in vivo

scientific article published on May 14, 1992

Effect of neuroleptic drugs on striatal dopamine release and metabolism in the awake rat studied by intracerebral dialysis ⬇️

scientific article published on October 30, 1984

Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.

scientific article

Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study

scientific article published on May 1999

Effects of co-administration of a monoamine oxidase inhibitor and a 5-HT1A receptor antagonist on 5-hydroxytryptamine cell firing and release

scientific article published on 01 February 1997

Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels

scientific article published on 8 April 2010

Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat.

scientific article published in January 1992

Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing

scientific article published on 02 June 2016

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

scientific article

Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanism

scientific article published in April 2002

Electroconvulsive shock increases dopamine D1 and D2 receptor mRNA in the nucleus accumbens of the rat

scientific article published on 01 August 1995

Electrophysiological evidence for convergence of inputs from the medial prefrontal cortex and lateral habenula on single neurons in the dorsal raphe nucleus.

scientific article published in January 2003

Enhancement of dopamine-mediated behaviour by the NMDA antagonists MK-801 and CPP: similarities with repeated electroconvulsive shock ⬇️

scientific article published on September 1, 1997

Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain.

scientific article published in June 2004

Evidence for a repetitive (burst) firing pattern in a sub-population of 5-hydroxytryptamine neurons in the dorsal and median raphe nuclei of the rat.

scientific article published in November 1995

Evidence for a role of GABA interneurones in the cortical modulation of midbrain 5-hydroxytryptamine neurones ⬇️

scientific article published on January 1, 2001

Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment

scientific article published on 30 June 2005

Evidence for the differential co-localization of neurokinin-1 receptors with 5-HT receptor subtypes in rat forebrain

scientific article published on 05 November 2011

Evidence that 5-HT2 receptor activation decreases noradrenaline release in rat hippocampus in vivo

scientific article published on September 1992

Evidence that central 5-HT and 5-HT receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat

scientific article published on 3 September 2003

Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat.

scientific article

Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function

scientific article

Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependent functional magnetic resonance imaging responses in the rat brain

scientific article published in January 2009

Evidence that the enhancement of dopamine function by repeated electroconvulsive shock requires concomitant activation of D1-like and D2-like dopamine receptors.

scientific article published in September 1997

Evidence that the large neutral amino acid L-valine decreases electrically-evoked release of 5-HT in rat hippocampus in vivo

scientific article published in January 1992

Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock

scientific article published on 01 December 1999

Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studies

scientific article published in December 2003

Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus

scientific article published on 24 November 2015

Fos expression in the brains of rats performing an attentional set-shifting task.

scientific article published on 16 September 2010

Fos immunocytochemical studies on the neuroanatomical sites of action of acute tyrosine depletion in the rat brain

scientific article published on 30 September 2003

Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378.

scientific article

Further pharmacological characterization of 5-HT(2C) receptor agonist-induced inhibition of 5-HT neuronal activity in the dorsal raphe nucleus in vivo

scientific article published on 20 October 2009

GABA and mood disorders.

scientific article published in April 2003

GABA transmission in the ventral pallidum is not involved in the control of latent inhibition in the rat.

scientific article published in January 2003

Genetic mouse models relevant to schizophrenia: Taking stock and looking forward

scientific article published on 16 August 2011

Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT₄ receptor levels

scientific article published on 16 August 2011

Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

scientific article published on 08 July 2016

GluN1 hypomorph mice exhibit wide-ranging behavioral alterations

scientific article

Glutamate receptor activation is involved in 5-HT2 agonist-induced Arc gene expression in the rat cortex.

scientific article published in March 2004

High frequency stimulation of the subthalamic nucleus increases c-fos immunoreactivity in the dorsal raphe nucleus and afferent brain regions

scientific article published on 08 June 2011

High-frequency stimulation of the substantia nigra induces serotonin-dependent depression-like behavior in animal models

scientific article published on 31 August 2012

High-frequency stimulation of the subthalamic nucleus inhibits the firing of juxtacellular labelled 5-HT-containing neurones

scientific article

High-frequency stimulation of the subthalamic nucleus modulates neuronal activity in the lateral habenula nucleus

scientific article

Important messages in the 'post': recent discoveries in 5-HT neurone feedback control

scientific article published on 9 November 2007

In vitro evidence that 5-hydroxytryptamine increases efflux of glial glutamate via 5-HT(2A) receptor activation.

scientific article published on February 2002

In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism

scientific journal article

In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain-raphe nuclei: role of 5-HT1A receptors

scientific article

In vivo measurement of dopamine and its metabolites by intracerebral dialysis: changes after d-amphetamine.

scientific article published in December 1983

In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis

scientific article published in January 1986

Increase of 5-HT7 (serotonin-7) and 5-HT1A (serotonin-1A) receptor mRNA expression in rat hippocampus after adrenalectomy.

scientific article

Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala

scientific article

Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo.

scientific article published on 5 July 2014

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats

scientific article published on 18 May 2008

Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission.

scientific article published in August 2006

Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs

scientific article (publication date: 15 February 2003)

Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms.

scientific article

Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus

scholarly article

Inhibition of median and dorsal raphe neurones following administration of the selective serotonin reuptake inhibitor paroxetine

scientific article published on 01 June 1995

Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT

scientific article published on July 1995

Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies

scientific article

Intracellular recordings from burst-firing presumed serotonergic neurones in the rat dorsal raphe nucleus in vivo.

scientific article published in October 1996

Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis

scientific article published on 23 January 2006

Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism

scientific article published in September 2003

Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine.

scientific article published on 16 June 2008

Mixed agonist/antagonist properties of NAN-190 at 5-HT1A receptors: behavioural and in vivo brain microdialysis studies.

scientific article published in January 1990

Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition

scientific journal article

Molecular adaptation to chronic antidepressant treatment: evidence for a more rapid response to the novel α₂-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, compared to the SNRI, venlafaxine

scientific article published on 17 May 2011

Molecular and Cellular Mechanisms of Antidepressant Action ⬇️

scientific article published on January 1, 2013

Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry

scientific article published in January 2000

Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo.

scientific article published in January 2003

Neurochemical identification of stereotypic burst-firing neurons in the rat dorsal raphe nucleus using juxtacellular labelling methods.

scientific article

Neuroscience. A new molecule to brighten the mood

scientific article published in January 2006

Neurovascular and neuroimaging effects of the hallucinogenic serotonin receptor agonist psilocin in the rat brain

scientific article published on 17 July 2015

Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals

scientific article

Olanzapine activates the rat locus coeruleus: in vivo electrophysiology and c-Fos immunoreactivity

scientific article

Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice

scientific article

Parkinson's disease, DBS and suicide: a role for serotonin?

scientific article published on 24 June 2009

Partial postsynaptic 5-HT1A agonist properties of the novel stereoselective 8-OH-DPAT analogue (+)cis-8-hydroxy-1-methyl-2-(di-n-propylamino)tetralin, (+)ALK-3

scientific article published on 01 November 1989

Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo

scientific article published on 10 April 2015

Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis

scientific article published on November 1989

Pharmacological evidence that 5-HT2C receptor blockade selectively improves decision making when rewards are paired with audiovisual cues in a rat gambling task.

scientific article

Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata.

scientific article

Pindolol occupancy of 5-HT(1A) receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635

scientific article published on 01 June 2000

Rapid postmortem increase in extracellular dopamine in the rat brain as assessed by brain microdialysis

scientific article published on 01 September 1988

Reduced sensitivity to both positive and negative reinforcement in mice over-expressing the 5-hydroxytryptamine transporter

scientific article

Region-specific effects of a tyrosine-free amino acid mixture on amphetamine-induced changes in BOLD fMRI signal in the rat brain

scientific article published on 01 November 2007

Regulation of markers of synaptic function in mouse models of depression: chronic mild stress and decreased expression of VGLUT1.

scientific article published on 10 June 2010

Release of 5-hydroxytryptamine (5-HT) from medullary and mesencephalic raphé neurones after grafting to the rat hippocampus: Evidence for regulation by 5-HT1A autoreceptors ⬇️

scientific article published on November 11, 1991

Release of cerebral 5-hydroxytryptamine evoked by electrical stimulation of the dorsal and median raphe nuclei: effect of a neurotoxic amphetamine

scientific article published on 01 October 1995

Release of endogenous 5-hydroxytryptamine in rat ventral hippocampus evoked by electrical stimulation of the dorsal raphe nucleus as detected by microdialysis: sensitivity to tetrodotoxin, calcium and calcium antagonists.

scientific article published in January 1990

Repeated ECS enhances dopamine D-1 but not D-2 agonist-induced behavioural responses in rats

scientific article published on 01 January 1990

Repeated administration of fluoxetine, desipramine and tranylcypromine increases dopamine D2-like but not D1-like receptor function in the rat

scientific article published on 01 January 1998

Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat.

scientific article published on April 1999

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

scientific article

S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization

scientific article

S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole

scientific article published on 20 February 2004

SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice.

scientific article

Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao(-/-)) mice.

scientific article published on February 2016

Selective 5-HT1A and 5-HT2 receptor-mediated adrenocorticotropin release in the rat: effect of repeated antidepressant treatments

scientific article published in October 1992

Serotonin, Amygdala and Fear: Assembling the Puzzle

scientific article published on 5 April 2016

Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?

scientific article published on 18 January 2011

Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions

scientific article

Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression.

scientific article published on 28 October 2010

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.

scientific article

Spike-timing relationship of neurochemically-identified dorsal raphe neurons during cortical slow oscillations

scientific article published on 10 September 2011

Stereoselective and region-specific induction of immediate early gene expression in rat parietal cortex by blockade of neurokinin 1 receptors

scientific article published on 4 October 2005

Striato-nigral dynorphin and substance P pathways in the rat. II. Functional analysis

scientific article

Structural and functional analysis of raphe neurone implants into denervated rat spinal cord

scientific article published on 01 January 1989

Studies on the role of 5-HT1A autoreceptors and alpha 1-adrenoceptors in the inhibition of 5-HT release--I. BMY7378 and prazosin

scientific article published on 01 June 1995

Studies on the role of calcium in the 5-HT-stimulated release of glutamate from C6 glioma cells

scientific article

Systemic inflammation alters central 5-HT function as determined by pharmacological MRI

scientific article

The novel 5-HT1A receptor antagonist, SDZ 216-525, decreases 5-HT release in rat hippocampus in vivo

scientific article published on July 1993

The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortex

scientific article published in April 2004

The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortex

scientific article

The putative 5-HT1A antagonist BMY 7378 blocks 8-OH-DPAT-induced changes in local cerebral glucose utilization in the conscious rat.

scientific article published on June 1992

The role of calcium in the pharmacology of mania

scholarly article by Timothy G. Dinan et al published June 1989 in Human Psychopharmacology

Tyrosine-free amino acid mixture attenuates amphetamine-induced displacement of [11C]raclopride in striatum in vivo: a rat PET study

scientific article published on February 2004

Tyrosine-free amino acid mixtures reduce physiologically-evoked release of dopamine in a selective and activity-dependent manner

scientific article published on 9 October 2013

Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration

scientific article

Variation in serotonin transporter expression modulates fear-evoked hemodynamic responses and theta-frequency neuronal oscillations in the amygdala

scientific article

Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain

scientific article published on 01 November 2000

beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy

scientific article published on September 2000

cis-(+)-8-OH-1-CH3-DPAT, (+)ALK-3, a novel stereoselective pharmacological probe for characterizing 5-HT release-controlling 5-HT1A autoreceptors. An in vivo brain microdialysis study

scientific article

d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption

scientific article published on 27 March 2015

p-Chloroamphetamine (PCA), 3,4-methylenedioxy-methamphetamine (MDMA) and d-fenfluramine pretreatment attenuates d-fenfluramine-evoked release of 5-HT in vivo.

scientific article published on December 1994

p-Chloroamphetamine releases both serotonin and dopamine into rat brain dialysates in vivo

scientific article published in December 1986

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