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List of works by George Aghajanian

Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

scientific article published on October 29, 2011

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

scientific article

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

scientific article published in July 2006

Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies

scientific article published on 28 January 2008

GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine.

scientific article published on 16 September 2016

GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine

scientific article published on 17 May 2013

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

scientific article published on February 3, 2011

Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors

scientific article

Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus

scientific article

Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice

scientific article

Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.

scientific article published in May 2005

Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions.

scientific article

Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses

scientific article

Medial prefrontal D1 dopamine neurons control food intake

scientific article

Modeling "psychosis" in vitro by inducing disordered neuronal network activity in cortical brain slices

scientific article published on 25 February 2009

Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β.

scientific article published on January 2014

Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus

scientific article published in September 2002

Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex

scientific article published in February 2003

Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions.

scientific article

Patricia Goldman-Rakic, 1937–2003

REDD1 is essential for stress-induced synaptic loss and depressive behavior

scientific article

Regulation of RGS proteins by chronic morphine in rat locus coeruleus

scientific article published in March 2003

Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone.

scientific article

Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors.

scientific article published in April 2006

Schizophrenia, hypocretin (orexin), and the thalamocortical activating system

scientific article

Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses.

scientific article

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice

scientific article published in March 2006

Signaling pathways underlying the rapid antidepressant actions of ketamine

scientific article published on September 2, 2011

Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases

scientific article published in February 2005

Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy

scientific article

Synaptic dysfunction in depression: potential therapeutic targets

scientific article

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

scientific article

Torgny Svensson, M.D., Ph.D. (1945-2020)

scientific article published on 22 July 2020

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

scientific article