List of works - Marco van de Weert

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

scientific article (publication date: May 2007)

Analysis of protein physical stability in lipid based delivery systems--the challenges of lipid drug delivery systems.

scientific article published in August 2009

Binding mode of Thioflavin T in insulin amyloid fibrils

scientific article published on 21 June 2007

Characterisation and physical stability of PEGylated glucagon

scientific article

Characterisation of salmon calcitonin in spray-dried powder for inhalation. Effect of chitosan

scientific article published on 27 October 2006

Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate.

scientific article published in November 2001

Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

scientific article published on 13 September 2006

Competitive adsorption of monoclonal antibodies and nonionic surfactants at solid hydrophobic surfaces

scientific article published on 01 December 2014

Complex coacervates of hyaluronic acid and lysozyme: effect on protein structure and physical stability.

scientific article

Complex coacervation of lysozyme and heparin: complex characterization and protein stability.

scientific article

Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

scientific article published on 15 May 2012

Determination of dissociation constants between polyelectrolytes and proteins by affinity capillary electrophoresis.

scientific article published on 11 February 2009

Drying methods for protein pharmaceuticals

scientific article published on 01 January 2008

Effect of ethanol as a co-solvent on the aerosol performance and stability of spray-dried lysozyme.

scientific article published on 9 September 2016

Effects of sucrose on rFVIIa aggregation and methionine oxidation.

scientific article published in April 2004

Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach

scientific article published on 06 May 2015

Fluorescence quenching to study protein-ligand binding: common errors.

scientific article published on 9 December 2009

Forced degradation of therapeutic proteins.

scientific article

Formation of dielectric layers and charge regulation in protein adsorption at biomimetic interfaces

scientific article published on 09 January 2012

Fourier transform infrared spectrometric analysis of protein conformation: effect of sampling method and stress factors

scientific article published on 01 October 2001

Fuzzy Logic-based expert system for evaluating cake quality of freeze-dried formulations

scientific article

Identification of oxidized methionine in peptides

scientific article published on 01 January 1996

Ionic strength-dependent denaturation of Thermomyces lanuginosus lipase induced by SDS

scientific article published on 17 November 2010

Kapp SJ, Larsson I, Van De Weert M, Ćardenas M, Jorgensen L. 2015. Competitive Adsorption of Monoclonal Antibodies and Nonionic Surfactants at Solid Hydrophobic Surfaces. 2015. J Pharm Sci 104:593-601

scientific article published on 18 June 2015

Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer

scientific article published on 01 March 2006

Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques

scientific article

Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation.

scientific article published on 21 June 2016

Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR

scientific article published on 11 May 2011

Preferential Interactions and the Effect of Protein PEGylation.

scientific article published on 31 July 2015

Preparing and evaluating delivery systems for proteins.

scientific article published on 25 May 2006

Probing insulin’s secondary structure after entrapment into alginate/chitosan nanoparticles

scientific article published on 24 September 2006

Probing structural changes of proteins incorporated into water-in-oil emulsions.

scientific article

Protein Adsorption at Charged Surfaces: The Role of Electrostatic Interactions and Interfacial Charge Regulation

scientific article published on 15 February 2011

Protein pharmaceuticals

scientific article published on 01 January 2008

Quality by design - Spray drying of insulin intended for inhalation

scientific article

Reversible aggregation of lysozyme in a biodegradable amphiphilic multiblock copolymer

scientific article published on 01 July 2002

Secondary nucleation and accessible surface in insulin amyloid fibril formation.

scientific article published in March 2008

Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering.

scientific article published on 26 July 2011

Serial coupling of ion-exchange and size-exclusion chromatography to determine aggregation levels in mAbs in the presence of a proteinaceous excipient, recombinant human serum albumin

scientific article published in December 2014

Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(ε)ω-carboxyheptadecanoyl) des(B30).

scientific article

Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems.

scientific article published in November 2002

Studies on human insulin adsorption kinetics at an organic–aqueous interface determined using a label-free electroanalytical approach

scientific article published on 23 December 2007

Study on the binding of Thioflavin T to β-sheet-rich and non-β-sheet cavities

scientific article published on 31 December 2006

The chaperone-like protein alpha-crystallin dissociates insulin dimers and hexamers

scientific article published on 01 October 2009

The effect of a water/organic solvent interface on the structural stability of lysozyme

scientific article published on 01 September 2000

The effect of protein PEGylation on physical stability in liquid formulation

scientific article published on 19 August 2014

Thermal dissociation and unfolding of insulin

scientific article published on 01 August 2005

Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection

scientific article published in November 2008

Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - prediction of viscosity through protein-protein interaction measurements.

scientific article published on 26 April 2013

List of works by Marco van de Weert

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

Analysis of protein physical stability in lipid based delivery systems--the challenges of lipid drug delivery systems.

Binding mode of Thioflavin T in insulin amyloid fibrils

Characterisation and physical stability of PEGylated glucagon

Characterisation of salmon calcitonin in spray-dried powder for inhalation. Effect of chitosan

Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate.

Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

Competitive adsorption of monoclonal antibodies and nonionic surfactants at solid hydrophobic surfaces

Complex coacervates of hyaluronic acid and lysozyme: effect on protein structure and physical stability.

Complex coacervation of lysozyme and heparin: complex characterization and protein stability.

Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

Determination of dissociation constants between polyelectrolytes and proteins by affinity capillary electrophoresis.

Drying methods for protein pharmaceuticals

Effect of ethanol as a co-solvent on the aerosol performance and stability of spray-dried lysozyme.

Effects of sucrose on rFVIIa aggregation and methionine oxidation.

Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach

Fluorescence quenching to study protein-ligand binding: common errors.

Forced degradation of therapeutic proteins.

Formation of dielectric layers and charge regulation in protein adsorption at biomimetic interfaces

Fourier transform infrared spectrometric analysis of protein conformation: effect of sampling method and stress factors

Fuzzy Logic-based expert system for evaluating cake quality of freeze-dried formulations

Identification of oxidized methionine in peptides

Ionic strength-dependent denaturation of Thermomyces lanuginosus lipase induced by SDS

Kapp SJ, Larsson I, Van De Weert M, Ćardenas M, Jorgensen L. 2015. Competitive Adsorption of Monoclonal Antibodies and Nonionic Surfactants at Solid Hydrophobic Surfaces. 2015. J Pharm Sci 104:593-601

Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer

Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques

Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation.

Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR

Preferential Interactions and the Effect of Protein PEGylation.

Preparing and evaluating delivery systems for proteins.

Probing insulin’s secondary structure after entrapment into alginate/chitosan nanoparticles

Probing structural changes of proteins incorporated into water-in-oil emulsions.

Protein Adsorption at Charged Surfaces: The Role of Electrostatic Interactions and Interfacial Charge Regulation

Protein pharmaceuticals

Quality by design - Spray drying of insulin intended for inhalation

Reversible aggregation of lysozyme in a biodegradable amphiphilic multiblock copolymer

Secondary nucleation and accessible surface in insulin amyloid fibril formation.

Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering.

Serial coupling of ion-exchange and size-exclusion chromatography to determine aggregation levels in mAbs in the presence of a proteinaceous excipient, recombinant human serum albumin

Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(ε)ω-carboxyheptadecanoyl) des(B30).

Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems.

Studies on human insulin adsorption kinetics at an organic–aqueous interface determined using a label-free electroanalytical approach

Study on the binding of Thioflavin T to β-sheet-rich and non-β-sheet cavities

The chaperone-like protein alpha-crystallin dissociates insulin dimers and hexamers

The effect of a water/organic solvent interface on the structural stability of lysozyme

The effect of protein PEGylation on physical stability in liquid formulation

Thermal dissociation and unfolding of insulin

Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection

Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - prediction of viscosity through protein-protein interaction measurements.