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List of works by Roland Brosch

"A re-evaluation of M. prototuberculosis": continuing the debate

scientific article published in September 2006

13 ESAT-6 and the Mycobacterial ESX Secretion Systems

A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent

scientific article published on 3 August 2014

A new evolutionary scenario for the Mycobacterium tuberculosis complex

scientific article

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

scientific article

A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component

scientific article

A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies

scientific article published on 04 March 2020

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts

scientific article published on 28 April 2016

Activation of the NLRP3 inflammasome byMycobacterium tuberculosisis uncoupled from susceptibility to active tuberculosis

scholarly article by Anca Dorhoi et al published 20 December 2011 in European Journal of Immunology

Analysis of the proteome of Mycobacterium tuberculosis in silico

article

Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis

scientific article published on 19 August 2005

Apports de la génomique des mycobactéries a la définition de nouvelles stratégies thérapeutiques et vaccinales anti-tuberculeuses

Bacillus Calmette-Guérin strain differences have an impact on clinical outcome in bladder cancer immunotherapy

scientific article published on 12 March 2014

Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant

scientific article

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

scientific journal article

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

scientific article

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6.

scientific article published on April 2004

Characterization of Listeria strains isolated from soft cheese

scientific article published on 01 April 1993

Characterization of Mycobacterium orygis

scientific article published in March 2013

Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies

scientific article

Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis.

scientific article published on February 2017

Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans

scientific article

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP

scientific journal article

Cutting-edge science and the future of tuberculosis control

scholarly article by Roland Brosch published 1 May 2007 in Bulletin of the World Health Organization

Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo

scientific article published on 6 February 2015

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

scientific article

Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237.

scientific article

Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis

scientific article published on 07 February 2020

Discovery of the type VII ESX-1 secretion needle?

scientific article published on 16 November 2016

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

scientific article

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence

scientific article

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity

scientific article published on 8 June 2007

ESAT-6 proteins: protective antigens and virulence factors?

scientific article

ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis

scientific journal article

ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo

scientific article published on 25 April 2016

ESX secretion systems: mycobacterial evolution to counter host immunity

scientific article published on 26 September 2016

ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis

scientific article published on 17 January 2017

ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells

scientific article

ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis

scientific article published on 2 August 2013

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

scientific article

ESX/Type VII Secretion Systems-An Important Way Out for Mycobacterial Proteins

scientific article published on 01 July 2019

ESX/type VII secretion systems and their role in host-pathogen interaction

scientific article published on 18 January 2009

ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection

scientific article published on 13 February 2015

Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens

scientific article published on 4 June 2004

Entrapment of intracytosolic bacteria by septin cage-like structures

scientific article

Epidémie de listériose en France en 1992 aspects microbiologiques

article

Evolution of Mycobacterium tuberculosis: New Insights into Pathogenicity and Drug Resistance

scientific article published on October 2016

Evolution of virulence in the Mycobacterium tuberculosis complex

scientific article published on 4 December 2017

Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

scientific article

Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism

scientific article

Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity

scientific article published on 27 July 2005

Genome plasticity of BCG and impact on vaccine efficacy

scientific article

Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications

scientific article published on 17 February 2016

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

scientific article published on 06 January 2013

Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: 'Aethiops vetus'.

scientific article published on 24 June 2016

Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations

scientific article

Genomics of theMycobacterium tuberculosiscomplex andMycobacterium leprae

Genomics ofMycobacterium Tuberculosis and Mycobacterium Leprae

scholarly article

Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain

scientific article

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans ⬇️

scientific article

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling

scientific journal article

High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors

scientific article

Horizontal Transfer of a Virulence Operon to the Ancestor of Mycobacterium tuberculosis

article

Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation

scientific article

Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus

scientific article published on 17 September 2013

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus.

scientific article published on 17 January 2018

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions

scientific article

Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system

scientific article

Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system

scientific article published in March 2005

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

scientific article

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members.

scientific article published on 20 November 2015

Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii

scientific article published on 25 February 2015

Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis

scientific article published on 08 March 2019

Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex?

scientific article published on March 2003

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

scientific article published on 15 August 2016

Leprosy in red squirrels.

scientific article published on November 2016

Les bacilles de la tuberculose bovine

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti

scientific article published in November 2002

Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex

scientific article published in February 2004

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin

scientific article published on August 2005

Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh

scientific article

Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh

scientific article

Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors.

scientific article

Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis

scientific article published on 15 January 2018

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions

scientific article published on 24 January 2017

Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families

scientific article published in 2009

Mycobacterial Pan-Genome Analysis Suggests Important Role of Plasmids in the Radiation of Type VII Secretion Systems

scientific article published on 8 January 2016

Mycobacterial Pathogenomics and Evolution

scientific article published on February 2014

Mycobacterial virulence: impact on immunogenicity and vaccine research

scientific article published on 28 November 2019

Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice

scientific article

Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages

scientific article published on 08 November 2019

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

scientific article published on September 2017

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity.

scientific article

Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development

scientific article

Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection

scientific article (publication date: February 2014)

Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis

scientific article published on 01 June 2009

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach

scientific article published on 27 September 2018

Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus

scientific article

Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants

scientific article published on 5 January 2011

Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

scientific article published on April 2009

Pathogenomics of Mycobacteria

article

Pathogenomics: Insights into Tuberculosis and Related Mycobacterial Diseases

scholarly article published 10 May 2006

Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access

scientific article published on 31 May 2016

Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death

scientific article published on 2 February 2012

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

scientific article

Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells

scientific article

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.

scientific article published on 18 June 2018

Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis

scientific article

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

scientific article published on March 2017

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

scientific article published on 14 April 2003

Release of mycobacterial antigens

scientific article

Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.

scientific article

Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

scientific article

Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics

scientific article published on January 2002

Shared Pathogenomic Patterns Characterize a New Phylotype, Revealing Transition toward Host-Adaptation Long before Speciation of Mycobacterium tuberculosis

scientific article published on 01 August 2019

Single cell measurements of vacuolar rupture caused by intracellular pathogens

scientific article published on 12 June 2013

Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential

scientific article published in April 2012

Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress

scientific article published on 10 May 2005

Subtyping of Listeria monocytogenes serovar 4b by use of low-frequency-cleavage restriction endonucleases and pulsed-field gel electrophoresis.

scientific article published in July 1991

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring

scientific article published on October 2010

Systematic genetic nomenclature for type VII secretion systems.

scientific article

TBCAP; tuberculosis annotation project

scientific article published on 16 January 2013

Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs

scientific article published on January 2014

Taxonomic Diversity of Pseudomonads Revealed by Computer-interpretation of Ribotyping Data

article by Roland Brosch et al published December 1996 in Systematic and Applied Microbiology

TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

scientific article published on 04 February 2020

The BCG Strain Pool: Diversity Matters

scientific article published on February 2016

The Biology and Epidemiology of Mycobacterium canettii

scientific article published in January 2017

The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability

scientific article

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

scientific article published on 23 November 2017

The Mycobacteria: a Postgenomic View

The PE and PPE Protein Families of Mycobacterium tuberculosis

scholarly article published 18 September 2017

Tools for the population genomics of the tubercle bacilli.

scientific article

Tuberculosis: from genome to vaccine

scientific article

Type VII Secretion Systems in Gram-Positive Bacteria

scientific article published on 7 January 2016

Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity

scientific article published on 01 August 2018

Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria

scientific article published on 10 December 2018

Use of pulsed field gel electrophoresis to compare large DNA-restriction fragments of Listeria monocytogenes strains belonging to serogroups 1/2 and 3

scientific article published on 01 December 1991

[The most ancestral mycobacterial ESX-4 secretion system is essential for intracellular growth of Mycobacterium abscessus within environmental and human phagocytes]

scientific article published on 01 October 2018

p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways

scientific article

pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

scientific article published on 27 January 2016

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