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List of works by Antonín Holý

(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication

scientific article

(S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity ⬇️

scientific article (publication date: 5 May 1978)

(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA]: a purine analogue with trypanocidal activity in vitro and in vivo.

scientific article published on April 1996

1-(3,5-O-Alkylidene-2-deoxy-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)uracils

2',3'-Dideoxy- and 3'-Azido-2',3'-dideoxynucleosides of 5-Phenyl-2(1H)-pyrimidinone. Preparation of 2',3'-Dideoxypentofuranoses

2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells

scientific article published on May 1990

5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production

scientific article published on 09 May 2014

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity

scientific article published on November 2003

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity

scientific article

6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity

scientific article published in October 2004

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs

scientific article published on January 2011

9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo

scientific article published on December 1989

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

scientific article

9-(S)-(2,3-Dihydroxypropyl)adenine inhibits the transformation of chick embryo fibroblasts infected with Rous sarcoma virus: Evidence for inhibition of enzymatic activity of isolated cellular protein kinases by the drug

scientific article published on November 1979

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo

scientific article

A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity

scientific article (publication date: 2013)

A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists

scientific article

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

scientific article published on 23 May 2011

A novel selective broad-spectrum anti-DNA virus agent

scientific article published on October 1986

Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria

scientific article published in July 2005

Activation by 9-(R)-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1alpha) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1beta) production

scientific article

Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft cultures

scientific article published on December 2005

Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models ⬇️

scientific article

Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice

scientific article

Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems

scientific article published on February 1996

Acyclic nucleoside bisphosphonates: synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines

scientific article

Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3

article

Acyclic nucleoside phosphonates as potential antineoplastic agents

scientific article

Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position

scientific article

Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity

scientific article published on 22 June 2011

Acyclic nucleoside phosphonates: a key class of antiviral drugs

scientific article

Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro

scientific article

Affinity electrophoresis: new simple and general methods of preparation of affinity gels

scientific article published on 01 September 1982

Aliphatic analogues of nucleotides: synthesis and affinity towards nucleases

scientific article published on January 1974

Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents

scientific article published on March 1985

Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells

scientific article published on 22 October 2007

An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli.

scientific article

Antiadenovirus activities of several classes of nucleoside and nucleotide analogues

scientific article published on March 2005

Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA).

scientific article published on January 1993

Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates

scientific article published on July 2002

Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP.

scientific article published on March 1997

Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma

scientific article published in July 2001

Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures

scientific article published on November 2002

Antiviral Acyclic Nucleoside Phosphonate Analogues as Inhibitors of Purine Nucleoside Phosphorylase ⬇️

scientific article published on January 1, 1998

Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus

scientific article published on January 1995

Antiviral activity of aliphatic nucleoside analogues: structure-function relationship

scientific article (publication date: May 1979)

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

scientific article

Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.

scientific article published on December 1995

Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants ⬇️

scientific article published on August 26, 2011

Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds

scientific article published on 14 February 2007

Antiviral acyclic nucleoside phosphonates structure activity studies

scientific article published on 30 June 2006

Antiviral effect of HPMPC (Cidofovir®), entrapped in cationic liposomes: In vitro study on MDBK cell and BHV-1 virus ⬇️

scientific article published on February 2, 2012

Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines

scientific article published on January 2005

Arrest of Trypanosoma brucei rhodesiense and T. brucei brucei in the S-phase of the cell cycle by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine ((S)-HPMPA) ⬇️

scientific article published on May 15, 1998

Capillary electrophoresis separation of the new anti-AIDS agents 9-(2-phosphonylmethoxyethyl)adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine in mixtures with some monoribonucleotides or the most common deoxynucleotides

scientific article

Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice

scientific article

Charge density study of hydrogen [(2,4-diaminopyrimidin-1-io)methyl]phosphonate monohydrate

scientific article published on 29 May 2002

Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector.

scientific article published in June 2009

Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening

scientific article published on 28 August 2012

Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes ⬇️

scientific article published on November 1, 2003

Czech bibliometric system fosters mediocre research

scientific article published in Nature

Degradation of 6-methyl-2'-deoxyuridine in the in vivo and in vitro systems of Escherichia coli

scientific article published on May 1974

Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase

scientific article

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

scientific article published on 29 April 2010

Determination of acid-base dissociation constants of amino- and guanidinopurine nucleotide analogs and related compounds by capillary zone electrophoresis

scientific article published in March 2006

Determination of the antioxidative activity of substituted 5-aminopyrimidines

scientific article

Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases alpha, delta and epsilon

scientific article

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

scientific article

Differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages

scientific article published on 21 December 2011

Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase

scientific article published on 27 October 2007

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.

scientific article published on 22 June 2010

Drug-induced hypomethylation of a posttranscriptionally silenced transgene locus of tobacco leads to partial release of silencing

scientific article

Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice

scientific article

Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo

scientific article

Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus

scientific article published in February 1998

Embryotoxicity of 9‐(s)‐(2,3‐dihydroxypropyl)adenine ⬇️

scientific article published on December 1, 1981

Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.

scientific article

Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity

scientific article published on 19 October 2007

Evaluation of the impact of S‐adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome ⬇️

scientific article published on March 15, 1998

Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3

scientific article published in December 2006

Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)

scientific article published on 01 September 2012

Facile preparation of purine and pyrimidine 2-deoxy-beta-D-ribonucleosides by biotransformation on encapsulated cells.

scientific article

Fluorescent analogs of acyclic S-adenosyl-L-homocysteinase inhibitors

scientific article published on January 1987

Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9.

scientific article published in May 2001

Genotoxicity of purine acyclic nucleotide analogs

scientific article published on January 1, 1997

Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, and 2,6-diaminopurines

scientific article published in August 2003

Immunomodulatory properties of antiviral acyclic nucleotide analogues: Cytokine stimulatory and nitric oxide costimulatory effects ⬇️

scientific article published on September 1, 1997

In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes

scientific article published on 14 January 2006

In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.

scientific article published on 11 October 2007

Inducible and constitutive nucleoside-binding sites in Escherichia coli: differential inhibition by nucleoside analogues

scientific article published on April 1974

Influence of Acyclic Nucleoside Phosphonate Antivirals on Gene Expression of Chemokine Receptors CCR5 and CXCR4.

scientific article

Inhibition of SAH-hydrolase activity during seed germination leads to deregulation of flowering genes and altered flower morphology in tobacco

scientific article published on 28 January 2011

Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues

scientific article

Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues

scientific article published in May 1990

Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir

scientific article published in January 2006

Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates

scientific article published in September 2005

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

scientific article

Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine ⬇️

scientific article published on October 15, 1997

Inhibition of nucleoside-binding sites by nucleoside analogues in Escherichia coli

scientific article published on March 1974

Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates

scientific article published on June 1999

Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines

scientific article published in May 2005

Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains

scientific article published on 9 April 2007

Inhibitory effects of 9-(2,3-dihydroxypropyl)adenine and 3-(adenin-9-yl)-2-hydroxypropanoic acid 2-methylpropylester on potato virus X replication

scientific article published on August 1988

Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication

scientific article published on May 1998

Interaction between Dehydrogenases and a New NAD⊕-Isomer ⬇️

scientific article published on November 1, 1975

Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes

scientific article

Interactions of calf spleen purine nucleoside phosphorylase with antiviral acyclic nucleoside phosphonate inhibitors: kinetics and emission studies

scientific article published on 01 April 1999

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

scientific article published on 19 August 2008

Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis

scientific article published on October 1987

Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine

scientific article published in December 2004

Intramolecular stacking interactions in ternary copper(II) complexes formed with 2,2'-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9.

scientific article published in March 2001

Investigation of the acid-base and electromigration properties of 5-azacytosine derivatives using capillary electrophoresis and density functional theory calculations.

scientific article

Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates

scientific article published on February 1, 2012

Involvement of adenosine A1 receptors in upregulation of nitric oxide by acyclic nucleotide analogues

scientific article published in October 2004

Kinetics of binding of multisubstrate analogue inhibitor (2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine) with trimeric purine nucleoside phosphorylase

scientific article published in January 2007

Macrophage activation by antiviral acyclic nucleoside phosphonates in dependence on priming immune stimuli

scientific article published in December 2000

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

scientific article

Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs

scientific article published on 8 October 2008

Metabolic phosphorylation and excretion of some nucleoside analogues in insects

scientific article published in April 1985

Metabolism of 9-(S)-(2,3-dihydroxypropyl)adenine, an antiviral agent, in mice

scientific article published on 01 August 1981

Metabolism of pyrimidine L-nucleosides ⬇️

scientific article published on August 1, 1976

Metal ion-binding properties of 1-methyl-4-aminobenzimidazole (=9-methyl-1,3-dideazaadenine) and 1,4-dimethylbenzimidazole (=6,9-dimethyl-1,3-dideazapurine). quantification of the steric effect of the 6-amino group on metal ion binding at the N7 sit

scientific article

Methylation of dinucleoside phosphates with diazomethane

scientific article published in April 1967

Methylation of inosine and uridylyl-(3'-5')inosine with dimethylsulfate

scientific article published on 01 December 1967

Microscopic-anatomical changes in the chick embryo after administration of 9-(RS)-(2,3-dihydroxypropyl) adenine

scientific article published in June 1987

Modulation of cell cycle progression and of antibody production in mouse hybridomas by a nucleotide analogue

scientific article published on November 1998

N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates

scientific article published on 28 February 2006

New carbocyclic nucleoside analogues built on a bicyclo[2.2.2]octane-2,2-dimethanol template

article published in 2009

New in vitro method for evaluating antiviral activity of acyclic nucleoside phosphonates against plant viruses

scientific article published on 7 October 2010

New prodrugs of Adefovir and Cidofovir

scientific article published on 22 April 2011

Nitric oxide production in mouse and rat macrophages: a rapid and efficient assay for screening of drugs immunostimulatory effects in human cells.

scientific article published on 4 July 2007

Norbornane as the novel pseudoglycone moiety in nucleosides

Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities

scientific article published on March 2005

Nucleoside conformations VI. Optical properties of 1,3-diribofuranosyl-6-methyl-uracil

scientific article published on 01 February 1972

Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.

scientific article

O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity

scientific article published in December 2001

Oligonucleotide Conformations. Optical Studies on GpU Analogues with Modified-Uridine Residues ⬇️

scientific article published on November 21, 1972

Oligonucleotide conformations. 4. Temperature and solvent effects on different uridylyl-uridines

scientific article published on August 1974

On the methylation of dinucleoside phosphates with diazomethane

scientific article published on 01 August 1966

On the prevention of thromboembolism (author's transl)

scientific article published on July 28, 1978

On the specificity of pancreatic ribonuclease towards 2',3'-cyclic phosphates derived from alpha-lyxofuranosyl derivatives of thymine

scientific article

P39. NO-upregulating and cytokine-stimulating activity of antiviral nucleotide analogues

PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.

scientific article published on November 2003

Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species

scientific article published on 15 July 2008

Phosphonate analogues of dinucleotides as substrates for DNA-dependent RNA polymerase from Escherichia coli in primed abortive initiation reaction.

scientific article

Phosphonomethoxyalkyl Analogs of Nucleotides ⬇️

scientific article published on January 1, 2003

Phosphonylmethoxyalkylpurines and -pyrimidines as inhibitors of African swine fever virus replication in vitro

scientific article

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

scientific article

Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase.

scientific article published in May 1990

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy

scientific article published in June 2010

Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.

scientific article published on 14 April 2011

Preparation of 5-Benzyluracil and 5-Benzylcytosine Nucleosides as Potential Inhibitors of Uridine Phosphorylase

Preparation of Chloro and Sulfanyl Derivatives of 1-(2-Deoxy-4-C-hydroxymethyl-α-L-threo-Pentofuranosyl)uracil

Preparation of Thymidine-4'-C-carboxylic Acid and Its Derivatives

Pretreatment of the host cell with 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is sufficient for its antiviral effect

scientific article

Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant

scientific article published in August 1990

Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.

scientific article published on 20 December 2005

Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase

scientific article

Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonom

scientific article published on 20 October 2004

Recognition of synonym codons by purified yeast tRNA-val fractions and fragments from tRNA1-val

scientific article published in January 1967

Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells

scientific article published on July 1, 2010

Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates

scientific article published on 21 July 2007

Some aspects of accident surgery problems (author's transl)

scientific article published on August 6, 1976

Stereospecific syntheses of 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA).

scientific article published on January 1987

Structure of 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine; an antiviral agent ⬇️

scientific article published on October 15, 1991

Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base

scientific article

Studies on the effect of 9-(R, S)-(2,3-dihydroxypropyl)adenine on tick-borne encephalitis virus

scientific article published on December 1, 1982

Studies on the reaction mechanism of a ribonuclease II from Aspergillus oryzae (author's transl)

scientific article published on February 1, 1975

Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy

scientific article published on 12 June 2008

Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase

scientific article published on 8 January 2008

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma

scientific article published on January 2007

Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines

Synthesis and Antiviral Activity of Various N4-Acyl Derivatives of Cidofovir and its 5-Azacytosine Counterpart, 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine

scientific article published in 2008

Synthesis and Biological Evaluation of Acyclic Nucleotide Analogues of Bicyclic Pyrimidine Bases

scientific article published in 2009

Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds

scientific article published on June 2004

Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds

scientific article published on June 2004

Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines

scientific article published on 4 March 2011

Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base

Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives

scientific article

Synthesis and structure–activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production

Synthesis of 1-(3-azido-2,3-dideoxy-β- d -allofuranosyl)thymine, 1-(2,3-dideoxy-β- d -allofuranosyl)thymine, and 1-(2,3-dideoxy-β- d - erythro -hex-2-enofuranosyl)thymine ⬇️

scientific article published on September 2, 1991

Synthesis of 1-(3-deoxy-beta-D-psicofuranosyl)uracil and related compounds

scientific article published on February 1974

Synthesis of 2'-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents

scientific article published on August 1996

Synthesis of 5-Phenyl-2(1H)-pyrimidinone Nucleosides

Synthesis of 5-Phenylcytosine Nucleoside Derivatives

Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases

scientific article published in April 2001

Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages

scientific article published in April 2005

Synthesis of Carba Analogues of 2'-Deoxy-4'-C-(hydroxymethyl)nucleosides

Synthesis of Carba Analogues of Deoxy-4-C-(hydroxymethyl)hexopyranoses, Intermediates in the Synthesis of Carbocyclic Nucleosides

Synthesis of Carba Analogues of Deoxy-4-C-(hydroxymethyl)pentofuranoses, Intermediates in the Synthesis of Carbocyclic Nucleosides

Synthesis of Carbocyclic 4'-C-Hydroxymethyl Analogues of Azidodeoxythymidine, Deoxythymidine, Deoxydidehydrothymidine and Thymidine Carba Analogue with Fused Oxetane Ring

Synthesis of Novel Carbocyclic Nucleoside Analogues Containing Bicyclo[2.2.1]hept-2-ene-2-methanol

Synthesis of Novel Carbocyclic Nucleoside Analogues Derived from 2-(Hydroxymethyl)bicyclo[2.2.1]heptane

Synthesis of Novel Carbocyclic Nucleosides and Pro-Tides Derived from 4-Oxatricyclo[4.2.1.03,7]nonane-9-methanol

Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 3-(Hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol

Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 5,5- and 6,6-Bis(hydroxymethyl)bicyclo[2.2.1]heptan-2-ol

Synthesis of Novel Racemic Conformationally Locked Carbocyclic Nucleosides Derived from 7-Substituted Bicyclo[2.2.1]hept-5-ene-2,2-dimethanols

Synthesis of Purine Nucleoside Analogues Derived from Carbocyclic 5-C-(Hydroxymethyl)hexopyranoses

article published in 2004

Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Nucleoside Analogues

Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Pyrimidine C-Nucleoside Analogues

Synthesis of Racemic 9-(6- and 2,6-Substituted 9H-Purin-9-yl)-5-oxatricyclo[4.2.1.03,7]nonane-3-methanols, Novel Conformationally Locked Carbocyclic Nucleosides

Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids

scientific article

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

scientific article published on 25 July 2009

Synthesis of guanidino analogues of PMPDAP and their immunobiological activity

scientific article published on 9 October 2007

Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol

Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against Coxsackie viruses

Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

scientific article published on 30 December 2011

Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*

scientific journal article

Ternary Copper(II) Complexes in Solution Formed With 8-Aza Derivatives of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)Ethyl]Adenine (PMEA).

scientific article published on January 2000

The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization

scientific article

The binding site for the 3′-terminus of aminoacyl-tRNA in the molecule of elongation factor TufromEscherichia coli ⬇️

scientific article published on February 15, 1979

The effect of some triribonucleoside diphosphates containing inosine on the binding of [14C]aminoacyl-tRNA to ribosomes.

scientific article

The inhibition of peptidyl transferase activity by aminoacyl derivatives of some nucleoside aliphatic analogues

scientific article published on October 1974

The metabolism of isocytidine in Escherichia coli

scientific article published on October 1974

The mutagenicity of azido derivatives of monosaccharides and alcohols and of N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines in Arabidopsis thaliana and in Salmonella typhimurium

scientific article published in January 1991

The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon

scientific article published in January 2004

Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine

scientific article published in September 2006

Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated ⬇️

scientific article published on January 1, 1995

Transport of nucleosides in Bacillus subtilis: the effect of purine nucleosides on the cytidine-uptake

scientific article published on April 1974

Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, interferon, and bropirimine ⬇️

scientific article published on September 1, 1992

Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity

scientific article published in 2006

Virus Inhibitory Activity of some Pyrimidine Derivatives and Trimethinium Salts in Tissue Culture ⬇️

scientific article published on January 1, 1974

Virus inhibitory effect of combination of 9-(S)-(2,3-dihydroxypropyl) adenine and 6-azauridine

scientific article published on January 1980

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