List of works - Alan L Parker

(LYS)(16)-based reducible polycations provide stable polyplexes with anionic fusogenic peptides and efficient gene delivery to post mitotic cells.

scientific article

12th annual congress of the European Society of Gene Therapy.

scientific article

8th international conference on oncolytic virus therapeutics.

scientific article published in December 2014

A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes

scientific article published on 17 August 2011

A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications

scientific article published in 2024

Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors

scientific article published on 27 May 2020

Ad5-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies

scientific article published on 24 May 2018

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery

scientific article

Adenovirus serotype 5 hexon mediates liver gene transfer

scientific article published in February 2008

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile

scientific article published on 9 August 2013

Author Correction: Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

scientific article published on 02 March 2020

Bacteriophage biopanning in human tumour biopsies to identify cancer-specific targeting ligands

scientific article

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

scientific article

COP35, a cholangiocarcinoma-binding oligopeptide, interacts with the clathrin heavy chain accompanied by GRP78.

scientific article

Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells

scientific article published on 02 March 2020

Capsid modification strategies for detargeting adenoviral vectors

scientific article published on January 2014

ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

scientific article published on 01 December 2021

Designer Oncolytic Adenovirus: Coming of Age.

scientific article

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

scientific article published in Nature Communications

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

scientific article published on 22 October 2008

Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector

scientific article

Enhanced gene transfer activity of peptide-targeted gene-delivery vectors

scientific article

Evaluation of CD46 re-targeted adenoviral vectors for clinical ovarian cancer intraperitoneal therapy

scientific article published on 27 May 2016

Evidence for contribution of CD4+ CD25+ regulatory T cells in maintaining immune tolerance to human factor IX following perinatal adenovirus vector delivery

scientific article published on 31 January 2015

Exploration of peptide motifs for potent non-viral gene delivery highly selective for dividing cells

scientific article

Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease.

scientific article

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

scientific article published on 20 January 2020

Histone deacetylase inhibitor trichostatin A sensitises cisplatin-resistant ovarian cancer cells to oncolytic adenovirus.

scientific article published on 29 May 2018

Hitting the Target but Missing the Point: Recent Progress towards Adenovirus-Based Precision Virotherapies

scientific article published on 11 November 2020

Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor

scientific article published on 04 September 2019

Identification of FGF receptor-binding peptides for cancer gene therapy

scientific article

Identification of an oligopeptide binding to hepatocellular carcinoma

scientific article

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

scientific article published on 08 May 2009

Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications

scientific article published on 06 January 2020

Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach

scientific article

Identification of oligopeptide binding to colon cancer cells separated from patients using laser capture microdissection

scientific article published on 01 June 2008

Identification of oligopeptides binding to peritoneal tumors of gastric cancer

scientific article

Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies

scientific article published on May 2015

Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors

scientific article

Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

scientific article published on 24 January 2007

Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications.

scientific article published on October 2008

Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors

scientific article published in January 2002

Manipulation of Adenovirus Interactions with Host Factors for Gene Therapy Applications ⬇️

scientific article published on February 1, 2012

Methodologies for monitoring nanoparticle formation by self-assembly of DNA with poly(l-lysine).

scientific article published in March 2002

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

scientific article published on 20 June 2006

Nonviral gene delivery: techniques and implications for molecular medicine.

scientific article published on 3 September 2003

Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications

scientific article

Precision virotherapies: Coming soon

article published in 2018

Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies.

scientific article published on April 2016

Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction.

scientific article published on 5 September 2013

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

scientific article

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

scientific article published on 16 May 2016

Retargeting adenovirus serotype 48 fiber knob domain by peptide incorporation

scientific article published on 11 April 2014

Safe management of surgical smoke in the age of COVID-19

scientific article published on 03 May 2020

Self-assembly of peptides into spherical nanoparticles for delivery of hydrophilic moieties to the cytosol

scientific article published on May 2010

Superlensing microscope objective lens.

scientific article

Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer ⬇️

scientific article published on 06 September 2019

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

scientific article

The Fiber Knob Protein of Human Adenovirus Type 49 Mediates Highly Efficient and Promiscuous Infection of Cancer Cell Lines Using a Novel Cell Entry Mechanism

scientific article published on 02 December 2020

The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells.

scientific article published on 24 January 2018

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

scientific article

Use of a phage display library to identify oligopeptides binding to the lumenal surface of polarized endothelium by ex vivo perfusion of human umbilical veins

List of works by Alan L Parker

(LYS)(16)-based reducible polycations provide stable polyplexes with anionic fusogenic peptides and efficient gene delivery to post mitotic cells.

12th annual congress of the European Society of Gene Therapy.

8th international conference on oncolytic virus therapeutics.

A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes

A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications

Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors

Ad5-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery

Adenovirus serotype 5 hexon mediates liver gene transfer

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile

Author Correction: Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Bacteriophage biopanning in human tumour biopsies to identify cancer-specific targeting ligands

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

COP35, a cholangiocarcinoma-binding oligopeptide, interacts with the clathrin heavy chain accompanied by GRP78.

Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells

Capsid modification strategies for detargeting adenoviral vectors

ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

Designer Oncolytic Adenovirus: Coming of Age.

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector

Enhanced gene transfer activity of peptide-targeted gene-delivery vectors

Evaluation of CD46 re-targeted adenoviral vectors for clinical ovarian cancer intraperitoneal therapy

Evidence for contribution of CD4+ CD25+ regulatory T cells in maintaining immune tolerance to human factor IX following perinatal adenovirus vector delivery

Exploration of peptide motifs for potent non-viral gene delivery highly selective for dividing cells

Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease.

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Histone deacetylase inhibitor trichostatin A sensitises cisplatin-resistant ovarian cancer cells to oncolytic adenovirus.

Hitting the Target but Missing the Point: Recent Progress towards Adenovirus-Based Precision Virotherapies

Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor

Identification of FGF receptor-binding peptides for cancer gene therapy

Identification of an oligopeptide binding to hepatocellular carcinoma

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications

Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach

Identification of oligopeptide binding to colon cancer cells separated from patients using laser capture microdissection

Identification of oligopeptides binding to peritoneal tumors of gastric cancer

Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies

Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors

Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications.

Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors

Manipulation of Adenovirus Interactions with Host Factors for Gene Therapy Applications ⬇️

Methodologies for monitoring nanoparticle formation by self-assembly of DNA with poly(l-lysine).

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

Nonviral gene delivery: techniques and implications for molecular medicine.

Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications

Precision virotherapies: Coming soon

Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies.

Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction.

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

Retargeting adenovirus serotype 48 fiber knob domain by peptide incorporation

Safe management of surgical smoke in the age of COVID-19

Self-assembly of peptides into spherical nanoparticles for delivery of hydrophilic moieties to the cytosol

Superlensing microscope objective lens.

Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer ⬇️

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

The Fiber Knob Protein of Human Adenovirus Type 49 Mediates Highly Efficient and Promiscuous Infection of Cancer Cell Lines Using a Novel Cell Entry Mechanism

The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells.

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

Use of a phage display library to identify oligopeptides binding to the lumenal surface of polarized endothelium by ex vivo perfusion of human umbilical veins