List of works - Matthew J. Smith

A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues

scientific article published on 22 August 2013

Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase

scientific journal article

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

scientific article published on 18 May 2016

Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel

scientific article published on 14 May 2019

Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans

scientific article (publication date: 23 December 2015)

Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival.

scientific article published on 17 July 2006

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

scientific article

FF domains of CA150 bind transcription and splicing factors through multiple weak interactions

scientific article

Inhibition of RAS function through targeting an allosteric regulatory site.

scientific article published on 7 November 2016

Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.

scientific article published on 19 January 2014

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

scientific journal article

NMR-based functional profiling of RASopathies and oncogenic RAS mutations.

scientific article published on 4 March 2013

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

scientific article published on 4 May 2015

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

scientific article published on 28 June 2012

RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway

scientific article published on 13 October 2020

Real-time NMR monitoring of biological activities in complex physiological environments

scientific article

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

scientific article published on 14 December 2009

Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays

scientific article

Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays

scientific article

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state

scientific article published on 10 July 2020

Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok.

scientific article

The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1

scientific journal article

List of works by Matthew J. Smith

A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues

Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel

Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans

Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival.

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

FF domains of CA150 bind transcription and splicing factors through multiple weak interactions

Inhibition of RAS function through targeting an allosteric regulatory site.

Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

NMR-based functional profiling of RASopathies and oncogenic RAS mutations.

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway

Real-time NMR monitoring of biological activities in complex physiological environments

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays

Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state

Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok.

The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1