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List of works by David M. Mutch

A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects

scientific article published on 26 October 2011

A distinct fatty acid profile underlies the reduced inflammatory state of metabolically healthy obese individuals

scientific article

A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health.

scientific article published on 31 May 2016

Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.

scientific article

Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake

scientific article published on 25 August 2010

An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet

scientific article published on 24 January 2005

Association between circulating ascorbic acid, α-tocopherol, 25-hydroxyvitamin D, and plasma cytokine concentrations in young adults: a cross-sectional study

scientific article

Both linoleic and α-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats

scientific article

Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain

scientific article

Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations.

scientific article published on 28 June 2008

Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes

scientific article

Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a randomized control trial

scientific article published on 01 October 2019

Comprehensive profiling of plasma fatty acid concentrations in young healthy Canadian adults

scientific article

Development of a Dietary Management Care Map for Metabolic Syndrome

scientific article published on September 2014

Dietary n-6/n-3 Ratio Influences Brain Fatty Acid Composition in Adult Rats

scientific article published on 21 June 2020

EPA and DHA have divergent effects on serum triglycerides and lipogenesis, but similar effects on lipoprotein lipase activity: a randomized controlled trial

scientific article published on 01 December 2019

Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation.

scientific article published on 13 December 2011

Ethnic- and sex-specific associations between plasma fatty acids and markers of insulin resistance in healthy young adults.

scientific article published on 17 June 2013

Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study

scientific article published on 21 April 2015

Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention

scientific article published on 06 March 2017

Exercise training increases the expression and nuclear localization of mRNA destabilizing proteins in skeletal muscle

scientific article published on 31 July 2013

FADS2 genotype influences whole-body resting fat oxidation in young adult men.

scientific article published on 16 March 2016

Fatty acid-gene interactions, adipokines and obesity.

scientific article published on 12 January 2011

Fish oil regulates blood fatty acid composition and oxylipin levels in healthy humans: A comparison of young and older men.

scientific article published on 17 December 2015

Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men

scientific article published on 21 March 2013

Fructose:glucose ratios--a study of sugar self-administration and associated neural and physiological responses in the rat.

scientific article published on 22 May 2015

Genetics of human obesity

article

Genomics: food and nutrition.

scientific article

Harnessing Metabolomics for Nutrition Research ⬇️

scientific article published on July 1, 2011

Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity.

scientific article

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

scientific article published on 2 February 2006

Identifying regulatory hubs in obesity with nutrigenomics

Impact of commensal microbiota on murine gastrointestinal tract gene ontologies

scientific article published on 29 June 2004

Individual saturated and monounsaturated fatty acids trigger distinct transcriptional networks in differentiated 3T3-L1 preadipocytes

scientific article published on 6 February 2013

Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis.

scientific article

LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition.

scientific article published on 13 January 2016

Lack of effects of fish oil supplementation for 12 weeks on resting metabolic rate and substrate oxidation in healthy young men: A randomized controlled trial

scientific article published on 17 February 2017

Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery

scientific article

Metabolomics Reveals Metabolically Healthy and Unhealthy Obese Individuals Differ in their Response to a Caloric Challenge

scientific article published on 14 August 2015

Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice

scientific article published on January 2007

Molecular insights into the role of white adipose tissue in metabolically unhealthy normal weight and metabolically healthy obese individuals

scientific article

Multi-omics Integrative Investigation of Fatty Acid Metabolism in Obese and Lean Subcutaneous Tissue

scientific article published on 15 June 2017

Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles

scientific article published on 3 December 2008

Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets.

scientific article published on 15 September 2017

North American ginseng influences adipocyte-macrophage crosstalk regulation of inflammatory gene expression

scientific article published on 18 July 2015

Nutrigenomics and nutrigenetics: the emerging faces of nutrition

scientific article

PEMT, Δ6 desaturase, and palmitoyldocosahexaenoyl phosphatidylcholine are increased in rats during pregnancy

scientific article published on 22 November 2017

Plasma concentration of cis9trans11 CLA in males and females is influenced by SCD1 genetic variations and hormonal contraceptives: a cross-sectional study.

scientific article published on 18 July 2013

Plasma levels of 14:0, 16:0, 16:1n-7, and 20:3n-6 are positively associated, but 18:0 and 18:2n-6 are inversely associated with markers of inflammation in young healthy adults

scientific article published on 15 December 2013

Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults

article

Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function

scientific article published on 6 March 2015

Proceedings from the 2013 Canadian Nutrition Society Conference on Advances in Dietary Fats and Nutrition

article

Putting the 'Ome' in lipid metabolism

scientific article

Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue

scientific article published on 29 June 2016

Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes.

scientific article

Regional variations in ABC transporter expression along the mouse intestinal tract

scientific article published on 12 March 2004

Rosiglitazone is superior to resveratrol in inducing the expression of glyceroneogenic genes in adipose tissue from obese participants

scientific article published on 16 November 2017

SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition

scientific article published on 28 April 2015

SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: Effects on cellular stress, inflammatory markers and fatty acid elongation

scientific article published on 25 September 2015

Safflower (n-6) and flaxseed (n-3) high-fat diets differentially regulate hypothalamic fatty acid profiles, gene expression, and insulin signalling

scientific article published on 8 December 2017

Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese

scientific article published on 23 June 2014

Sex Differences in Blood HDL-c, the Total Cholesterol/HDL-c Ratio, and Palmitoleic Acid are Not Associated with Variants in Common Candidate Genes

scientific article published on 27 October 2017

Single Nucleotide Polymorphisms in Taste Receptor Genes Are Associated with Snacking Patterns of Preschool-Aged Children in the Guelph Family Health Study: A Pilot Study

scientific article published on 30 January 2018

Stearoyl-CoA desaturase 1, elongase 6 and their fatty acid products and precursors are altered in ovariectomized rats with 17β-estradiol and progesterone treatment

scientific article published on 16 June 2013

Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obese Men and Women both Acutely Suppress Muscle Insulin Signaling

scientific article

The Association between Plasma Omega-6/Omega-3 Ratio and Anthropometric Traits Differs by Racial/Ethnic Groups and Genotypes in Healthy Young Adults

scientific article published on 16 February 2019

The Global Error Assessment (GEA) model for the selection of differentially expressed genes in microarray data

scientific article

The Relationship between Fatty Acids and Different Depression-Related Brain Regions, and Their Potential Role as Biomarkers of Response to Antidepressants

scientific article published on 17 March 2017

The disruption of hepatic cytochrome p450 reductase alters mouse lipid metabolism

scientific article published on 28 August 2007

The limit fold change model: a practical approach for selecting differentially expressed genes from microarray data

scientific article

The role of FADS1/2 polymorphisms on cardiometabolic markers and fatty acid profiles in young adults consuming fish oil supplements

scientific article

Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids

scientific article published on 12 June 2013

Two-way learning with one-way supervision for gene expression data.

scientific article

Unraveling the adipocyte inflammomodulatory pathways activated by North American ginseng ⬇️

scientific article published on April 17, 2012

Unraveling the genetics of human obesity

scientific article

Using gene expression to predict the secretome of differentiating human preadipocytes.

scientific article published on 17 February 2009

Vaccenic acid in serum triglycerides is associated with markers of insulin resistance in men

scientific article published on 21 June 2012

Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults.

scientific article published on 16 July 2013

[Letter to the Editor] Protein phosphorylation status is preserved following dual RNA and protein extraction using the Qiagen RNeasy Mini Kit.

scientific article published on November 2016

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