List of works - Kevin Duffy

A highly efficient, asymmetric synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

scientific article published in November 2005

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

scientific article published on 27 January 2003

Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis

scientific article published on 4 October 2008

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

scientific article published on August 2010

Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K

scientific article published on 01 July 1999

Design of amidobenzimidazole STING receptor agonists with systemic activity

scientific article published in Nature

Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.

scientific article

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295.

scientific article published on 19 January 2010

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.

scientific article

Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.

scientific article published on August 2002

Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist

scientific article

Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury ⬇️

scientific article published on January 18, 2012

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

scientific article

Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase

scientific article

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.

scientific article published on 27 May 2009

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

scientific article

List of works by Kevin Duffy

A highly efficient, asymmetric synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K

Design of amidobenzimidazole STING receptor agonists with systemic activity

Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295.

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.

Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.

Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist

Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury ⬇️

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.