List of works - Babal Kant Jha

A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms

scientific article published on 07 December 2020

A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency

scientific article published on 21 September 2020

A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.

scientific article published on 7 March 2007

A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L

scientific article (publication date: June 2008)

Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology

scientific article published on June 2012

Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes

scientific article published on 24 February 2022

Consequences of mutant TET2 on clonality and subclonal hierarchy

scientific article published on 24 May 2018

Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

scientific article published on 07 September 2020

Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network

scientific article published on 07 August 2020

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

scientific article

Disulfide bond formation through Cys186 facilitates functionally relevant dimerization of trimeric hyaluronan-binding protein 1 (HABP1)/p32/gC1qR.

scientific article published in January 2002

Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L

scientific article

Evidence for inhibitory interaction of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) with Streptococcus pneumoniae hyaluronidase.

scientific article

Hepatitis C virus RNA: Dinucleotide frequencies and cleavage by RNase L

scientific article

Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.

scientific article

Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L.

scientific article published on 21 December 2016

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.

scientific article

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting

scientific article published in 2024

Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene.

scientific article

New insights into the role of RNase L in innate immunity

scientific article

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

scientific article published on 3 August 2011

Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.

scientific article

Role of 2-5A-dependent RNase-L in senescence and longevity.

scientific article published on 20 November 2006

Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells

scientific article published on December 2006

Small-molecule activators of RNase L with broad-spectrum antiviral activity

scientific article

Structural architecture of an RNA that competitively inhibits RNase L.

scientific article published on 23 November 2011

Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death

scientific article published on 23 April 2020

Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death

scientific article published on 01 October 2020

Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy

scientific article published on 04 June 2013

The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells ⬇️

scientific article published on November 5, 2010

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

scientific article

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

scientific article

List of works by Babal Kant Jha

A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms

A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency

A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.

A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L

Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology

Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes

Consequences of mutant TET2 on clonality and subclonal hierarchy

Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

Disulfide bond formation through Cys186 facilitates functionally relevant dimerization of trimeric hyaluronan-binding protein 1 (HABP1)/p32/gC1qR.

Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L

Evidence for inhibitory interaction of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) with Streptococcus pneumoniae hyaluronidase.

Hepatitis C virus RNA: Dinucleotide frequencies and cleavage by RNase L

Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.

Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L.

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting

Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene.

New insights into the role of RNase L in innate immunity

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.

Role of 2-5A-dependent RNase-L in senescence and longevity.

Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells

Small-molecule activators of RNase L with broad-spectrum antiviral activity

Structural architecture of an RNA that competitively inhibits RNase L.

Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death

Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death

Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy

The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells ⬇️

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response