List of works - Lee B Meakin

Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes

scientific article

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice

scientific article published on 25 January 2020

Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition

scientific article

Colored Indicator Undergloves Increase the Detection of Glove Perforations by Surgeons During Small Animal Orthopedic Surgery: A Randomized Controlled Trial.

scientific article published on 14 July 2016

Deletion of P58(IPK), the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice

scientific article

Disuse rescues the age-impaired adaptive response to external loading in mice

scientific article

Electrosurgery reduces blood loss and immediate postoperative inflammation compared to cold instruments for midline celiotomy in dogs: A randomized controlled trial.

scientific article published on 17 March 2017

Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.

scientific article published on 29 January 2013

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.

scientific article published on February 2013

Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice.

scientific article

Indicator gloves not better than double standard gloves

scientific article published on 01 February 2017

Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight

scientific article published on 26 January 2013

Mechanical properties of 6 finger-trap suture techniques.

scientific article published on 8 April 2017

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

scientific article published on 16 January 2020

Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results

scientific article published on 23 October 2019

Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle.

scientific article

Outcomes of dogs treated for extrahepatic congenital portosystemic shunts with thin film banding or ameroid ring constrictor

scientific article published on 04 July 2019

Parathyroid hormone's enhancement of bones' osteogenic response to loading is affected by ageing in a dose- and time-dependent manner

scientific article

Planar cell polarity aligns osteoblast division in response to substrate strain

scientific article

Prevalence, outcome and risk factors for postoperative pyothorax in 232 dogs undergoing thoracic surgery.

scientific article published on 15 April 2013

Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.

scientific article

Quantification of Alterations in Cortical Bone Geometry Using Site Specificity Software in Mouse models of Aging and the Responses to Ovariectomy and Altered Loading

scientific article

Reliability of CT measurement of induced radioulnar step in dogs using a circle superimposition technique

scientific article

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice

scientific article

Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading

scientific article published on June 2011

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

scientific article

Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis

scientific article

The Contribution of Experimental in vivo Models to Understanding the Mechanisms of Adaptation to Mechanical Loading in Bone

scientific article

The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice

scientific article published on 14 February 2012

Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone.

scientific article published on 9 October 2015

List of works by Lee B Meakin

Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice

Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition

Colored Indicator Undergloves Increase the Detection of Glove Perforations by Surgeons During Small Animal Orthopedic Surgery: A Randomized Controlled Trial.

Deletion of P58(IPK), the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice

Disuse rescues the age-impaired adaptive response to external loading in mice

Electrosurgery reduces blood loss and immediate postoperative inflammation compared to cold instruments for midline celiotomy in dogs: A randomized controlled trial.

Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.

Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice.

Indicator gloves not better than double standard gloves

Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight

Mechanical properties of 6 finger-trap suture techniques.

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results

Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle.

Outcomes of dogs treated for extrahepatic congenital portosystemic shunts with thin film banding or ameroid ring constrictor

Parathyroid hormone's enhancement of bones' osteogenic response to loading is affected by ageing in a dose- and time-dependent manner

Planar cell polarity aligns osteoblast division in response to substrate strain

Prevalence, outcome and risk factors for postoperative pyothorax in 232 dogs undergoing thoracic surgery.

Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.

Quantification of Alterations in Cortical Bone Geometry Using Site Specificity Software in Mouse models of Aging and the Responses to Ovariectomy and Altered Loading

Reliability of CT measurement of induced radioulnar step in dogs using a circle superimposition technique

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice

Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis

The Contribution of Experimental in vivo Models to Understanding the Mechanisms of Adaptation to Mechanical Loading in Bone

The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice

Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone.