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List of works by John P. Moore

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

scientific article published on 30 October 2015

A Plea for Justice for Jailed Medical Workers

scientific article published in Science

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

scientific article

A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses

scientific article

A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120.

scientific article published on 28 November 2006

A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells

scientific article

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

scientific article

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

scientific article

A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells

scientific article published on 20 June 2011

AIDS/HIV. A STEP into darkness or light?

scientific article published on 01 May 2008

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

scientific article published on December 2015

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

scientific article

An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells

scientific article

Animal Models for Microbicide Studies ⬇️

scientific article published on January 1, 2012

Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

scientific article published on 23 June 2020

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

scientific article

Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes

scientific article published on 30 September 2019

Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

scientific article

Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission

scientific article published on January 2008

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

scientific article published on 20 February 2013

Autoantibodies induced by chimeric cytokine-HIV envelope glycoprotein immunogens.

scientific article

Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.

scientific article

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

scientific article

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

scientific article published on 24 April 2014

CD4-induced activation in a soluble HIV-1 Env trimer

scientific article

Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide

scientific article published in Nature Communications

Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands

scientific article

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

scientific article published on 21 October 2013

Clinical adjuvant combinations stimulate potent B-cell responses in vitro by activating dermal dendritic cells

scientific article

Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes

article

Comparative Immunogenicity of Evolved V1V2-Deleted HIV-1 Envelope Glycoprotein Trimers ⬇️

scientific article published on June 26, 2013

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

scientific article

Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

scientific article published on 01 June 2019

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

scientific article published on 28 August 2017

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

scientific article

Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens

scientific article published on 15 February 2019

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

scientific article

Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1

scientific article published in April 1997

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

scientific article

Dominant-negative effect of hetero-oligomerization on the function of the human immunodeficiency virus type 1 envelope glycoprotein complex.

scientific article published on 17 April 2006

Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency viruses

scientific article published in October 2004

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro.

scientific article

Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance ⬇️

scientific article published on April 19, 2012

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

scientific article published on 19 September 2019

Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins

scientific article

Entry Inhibitors SCH-C, RANTES, and T-20 Block HIV Type 1 Replication in Multiple Cell Types ⬇️

scientific article published on March 1, 2003

Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes

scientific article published on 10 April 2007

Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?

scientific article published on 01 April 2020

Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors ⬇️

scientific article published on October 22, 2011

Enzymatic removal of mannose moieties can increase the immune response to HIV-1 gp120 in vivo

scientific article published on 02 May 2009

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

scientific article published on 23 February 2018

Evaluating the immunogenicity of a disulfide-stabilized, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1

scientific article

Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41

scientific article

Evolutionary repair of HIV type 1 gp41 with a kink in the N-terminal helix leads to restoration of the six-helix bundle structure

scientific article published on July 2004

Glycan-dependent immunogenicity of recombinant soluble trimeric hemagglutinin

scientific article

Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines ⬇️

scientific article published on October 1, 2012

HIV's Achilles' Heel

scientific article published on November 2016

HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies

scientific article

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

scientific article

HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors

scientific article

HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

scientific article

HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

article

HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells

scientific article

HIV-1 pathogenesis: the complexities of the CCR5-CCL3L1 complex

scientific article

HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers

scientific article published on 9 August 2017

HIV: A stamp on the envelope

scientific article published on 8 October 2014

High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers

scientific article published on 6 September 2017

How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?

scientific article published on 20 May 2011

Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells

scientific article

IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines

scientific article

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

scientific article

Immunogenicity in rabbits of SOSIP trimers from clades A, B and C, given individually, sequentially or in combinations

scientific article published on 24 January 2018

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

scientific article

Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.

scientific article

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

scientific article

Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities

scientific article published on 20 March 2009

Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

scientific article published on 26 August 2015

Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein

scientific article published on 03 July 2013

Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages

scientific article

Is there enough gp120 in the body fluids of HIV-1-infected individuals to have biologically significant effects?

scientific article published on May 2004

Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function

scientific article published on 21 March 2010

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody ⬇️

scientific article published on June 20, 2011

Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission

scientific article

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

scientific article published on 31 August 2020

Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors.

scientific article published on 15 June 2011

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

scientific article

N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus

scientific article published on 26 November 2007

Native-like Env trimers as a platform for HIV-1 vaccine design

scientific article published on January 2017

Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

scientific article published on 28 February 2020

Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers

scientific article published on 30 September 2020

Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc.

scientific article published on 12 August 2011

Occluding the mannose moieties on human immunodeficiency virus type 1 gp120 with griffithsin improves the antibody responses to both proteins in mice.

scientific article published on 27 July 2011

Oligomeric and conformational properties of a proteolytically mature, disulfide-stabilized human immunodeficiency virus type 1 gp140 envelope glycoprotein

scientific article published on August 2002

Optimizing the production and affinity purification of HIV-1 envelope glycoprotein SOSIP trimers from transiently transfected CHO cells

article

P05-05. Enhanced immunogenicity of HIV-1 envelope glycoprotein trimers fused to CD40 ligand.

scientific article

Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers

scientific article

Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220 ⬇️

scientific article published on October 28, 2012

Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220.

scientific article published on 15 March 2013

Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques ⬇️

scientific article published on October 30, 2012

Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application

scientific article published on 30 December 2013

Potent Induction of Antibody-Secreting B Cells by Human Dermal-Derived CD14+ Dendritic Cells Triggered by Dual TLR Ligation ⬇️

scientific article published on November 16, 2012

Potent induction of antibody-secreting B-cells by human dermal-derived CD14+ dendritic cells triggered by dual toll-like receptor ligation

scientific article published on 13 September 2012

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

scientific article

Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120.

scientific article published on 10 February 2003

Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

scientific article published on 6 November 2005

Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion

scientific article

Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor

scientific article

Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.

scientific article published on June 1996

Rat monoclonal antibodies to nonoverlapping epitopes of human immunodeficiency virus type 1 gp120 block CD4 binding in Vitro ⬇️

scientific article published on November 1, 1991

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies

article

Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664.

scientific article published on 05 January 2017

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

scientific article

Recombinant gp120, antibodies to the V3 region of gp120, and neural progenitor cells

scientific article published on 01 March 2005

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

scientific article

Refocussing Antibody Responses by Chemical Modification of Vaccine Antigens

article

Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41 ⬇️

scientific article published on February 26, 2011

Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.

scholarly article

SARS-CoV-2 vaccines: 'Warp Speed' needs mind melds not warped minds

scientific article published on 26 June 2020

SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses

scientific article (publication date: 2011)

SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers

scientific article published on 12 December 2019

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.

scientific article

Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein

scientific article

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen

article

Specific amino acids in the N-terminus of the gp41 ectodomain contribute to the stabilization of a soluble, cleaved gp140 envelope glycoprotein from human immunodeficiency virus type 1.

scientific article published on 7 November 2006

Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers

article

Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers

scientific article published on 8 December 2017

Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1.

scientific article

Stabilized HIV-1 Envelope Glycoprotein Trimers Lacking the V1V2 Domain, Obtained by Virus Evolution ⬇️

scientific article published on September 8, 2010

Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

scientific article published on 25 April 2014

Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

scientific article published on 16 June 2015

Structural and biological mimicry of protein surface recognition by  / -peptide foldamers

scientific article

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

scientific article published on 11 August 2020

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers

scientific article published on 03 July 2013

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

scientific article

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

scientific article published on 29 May 2019

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

scientific article

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

scientific article published on 04 October 2016

Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques

scientific article

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

scientific article published on 11 May 2020

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

scientific article published on 04 August 2020

Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses

scientific article published on 28 December 2011

Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients

scientific article published on 22 November 2020

The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence

The impact of envelope glycoprotein cleavage on the antigenicity, infectivity, and neutralization sensitivity of Env-pseudotyped human immunodeficiency virus type 1 particles

scientific article published on July 2005

The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.

scientific article

Thermodynamic and kinetic analysis of sCD4 binding to HIV-1 virions and of gp120 dissociation

scientific article published on April 1992

Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.

scientific article published on 26 December 2012

Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

scientific article

Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.

scholarly article

Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry

scientific article

Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.

scientific article published on 6 March 2013

Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.

scientific article

V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc ⬇️

scientific article published on March 16, 2012

V3: HIV's switch-hitter

scientific article

What Do Chaotrope-Based Avidity Assays for Antibodies to HIV-1 Envelope Glycoproteins Measure?

scientific article published on 25 March 2015

Which topical microbicides for blocking HIV-1 transmission will work in the real world?

scientific article published in September 2006

cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate

scientific article

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