List of works by Adam S. Butterworth

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design.

scientific article published on 03 May 2017

A cross-platform approach identifies genetic regulators of human metabolism and health

scientific article published on 07 January 2021

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

scientific article published on June 2016

ACE inhibition and cardiometabolic risk factors, lung <i>ACE2</i> and <i>TMPRSS2</i> gene expression, and plasma ACE2 levels: a Mendelian randomization study

scientific article published on 18 November 2020

Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.

scientific article

An atlas of genetic scores to predict multi-omic traits

scientific article published on 29 March 2023

Array CGH in patients with learning disability (mental retardation) and congenital anomalies: updated systematic review and meta-analysis of 19 studies and 13,926 subjects

scientific article published on March 2009

Assessing the causal association of glycine with risk of cardio-metabolic diseases

scientific article published on 05 March 2019

Association analyses based on false discovery rate implicate new loci for coronary artery disease ⬇️

scientific article published on 17 July 2017

Association of Cardiometabolic Multimorbidity With Mortality

scientific article

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk

scientific article

Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study

scientific article published on 09 February 2016

Association of menopausal characteristics and risk of coronary heart disease: a pan-European case–cohort analysis

scientific article published on 01 August 2019

Association of the 9p21.3 locus with risk of first-ever myocardial infarction in Pakistanis: case-control study in South Asia and updated meta-analysis of Europeans

scientific article published on 15 April 2010

Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

scientific article published in Nature Communications

Author Correction: Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

scientific article published in Nature Communications

Author Correction: Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

scientific article published on 20 February 2020

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 01 June 2019

Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors

scientific article published on 17 August 2015

C-reactive protein, fibrinogen, and cardiovascular disease prediction

scientific article published on October 2012

Clinical utility of genetic variants for cardiovascular risk prediction: a futile exercise or insufficient data?

scientific article published in August 2012

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

scientific article published on 2 March 2016

Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study

scientific article published on 11 July 2017

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

scientific article published in Nature Communications

Comparative validity of vitamin C and carotenoids as indicators of fruit and vegetable intake: a systematic review and meta-analysis of randomised controlled trials

scientific article published on 09 September 2015

Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

scientific article

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

scientific article published on 26 September 2016

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

scientific article published on 22 May 2017

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases

scientific article

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm

scientific article

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic determinants of major blood lipids in Pakistanis compared with Europeans.

scientific article published on 22 June 2010

Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

scientific article

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

scientific article published on 16 December 2019

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

scientific article published on 11 September 2019

Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases

scientific article

Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

scientific article published in Nature Communications

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

scientific article published on 16 October 2020

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

scientific article published on 20 December 2019

Glycated hemoglobin measurement and prediction of cardiovascular disease

scientific article

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

scientific article published on 4 September 2017

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

scientific article

Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis

scientific article

Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour

scientific article

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

scientific article published on 14 March 2012

Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study

scientific article published on 10 February 2022

Large genome-wide association study identifies three novel risk variants for restless legs syndrome

scientific article published on 25 November 2020

Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis

scientific article

Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis

scientific article

Linkage analysis of rheumatoid arthritis in US and UK families reveals interactions between HLA–DRB1 and loci on chromosomes 6q and 16p

article

Lipid-related markers and cardiovascular disease prediction

scientific article

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition

scientific article published on 20 December 2019

Mendelian randomization analysis with multiple genetic variants using summarized data

scientific article

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

scientific article published on 07 January 2019

Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis

scientific article

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

scientific article

Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

scientific article published on 10 February 2020

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

scientific article published in October 2017

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 25 February 2019

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

scholarly article published 12 June 2018

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study

scientific article published on 4 July 2016

PhenoScanner: a database of human genotype-phenotype associations.

scientific article published on 17 June 2016

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

scientific article published on 07 September 2020

Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations

scientific article published on 17 November 2020

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

scientific article

Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting

scientific article published on 21 February 2017

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

scientific article published on 29 June 2017

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

scientific journal article

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

scientific article published on 9 April 2018

Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis

scientific article

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.

scientific article

Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis

scientific article published on 14 August 2017

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis

scientific article published on 15 October 2008

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

scientific article published on February 2017

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

scientific article published on 02 October 2019

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

scientific article

The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design

scientific article published in May 2015

The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis

scientific article published on 16 October 2020

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

scientific article

Turning the Pump Handle: Evolving Methods for Integrating the Evidence on Gene-Disease Association

article

Use of Mendelian randomisation to assess potential benefit of clinical intervention

scientific article

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

scientific article published on 23 May 2017

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