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List of works by Keith D. Robertson

A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma.

scientific article

A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding.

scientific article published on 13 October 2009

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome.

scientific article

Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity

scientific article published on 20 March 2019

An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis.

scientific article published on October 2006

Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors.

scientific article published on 8 March 2004

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells.

scientific article

CAME: identification of chromatin accessibility from nucleosome occupancy and methylome sequencing

scientific article

Comparative epigenomics of human and mouse mammary tumors.

scientific article

DNA methylation age is accelerated in alcohol dependence

scientific article published on 05 September 2018

DNA methylation and chromatin - unraveling the tangled web.

scientific article

DNA methylation and human disease

scientific article (publication date: August 2005)

DNA methylation in development and human disease

scientific article published on 20 August 2008

DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

scientific article published on 8 November 2007

DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma.

scientific article

DNA methylation: superior or subordinate in the epigenetic hierarchy?

scientific article

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function.

scientific article

DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer.

scientific article published on September 2009

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

scientific article (publication date: July 2000)

DNMT1 knockout delivers a strong blow to genome stability and cell viability

scientific article published on 01 March 2007

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

scientific article published on 29 May 2009

Dimethyl sulfoxide stimulates the catalytic activity of de novo DNA methyltransferase 3a (Dnmt3a) in vitro.

scientific article

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

scientific article

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues.

scientific article published on 27 March 2018

Doxorubicin inhibits DNMT1, resulting in conditional apoptosis.

scientific article published on 31 August 2004

Dynamic interrelationships between DNA replication, methylation, and repair

scientific article

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma.

scientific article published on 5 December 2015

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq

scientific article published on 29 March 2019

Epigenetic mechanisms and genome stability.

scientific article

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis.

scientific article

Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression.

scientific article

Epigenetics of gastrointestinal diseases: notes from a workshop

scientific article published on 30 July 2018

Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma.

scientific article published on August 2006

Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma

scientific article

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

scientific article

Histone deacetylase inhibitors for cancer therapy.

scientific article published on January 2006

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern

scientific article published on 25 June 2004

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome.

scientific article

In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma

scientific article published on 30 July 2019

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.

scientific article published on 25 February 2006

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer

scientific article published on 6 January 2017

Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis

scientific article published in 2021

Loss of SETD2 induces a metabolic switch in renal cell carcinoma cell lines toward enhanced oxidative phosphorylation

article

Missteps in "tango" for epigenome targeting

scientific article published on 01 September 2009

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants

scientific journal article

Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor

scientific article published on January 2012

Nucleosome positioning changes during human embryonic stem cell differentiation.

scientific article published on 18 April 2016

Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis

scientific article published on 01 October 2018

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer.

scientific article

Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.

scientific article published on 30 January 2002

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application.

scientific article published on 21 December 2017

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery.

scientific article published on 11 October 2010

Roles of cell division and gene transcription in the methylation of CpG islands.

scientific article

SHP2 inhibition enhances Yes-associated protein–mediated liver regeneration in murine partial hepatectomy models

scientific article published in 2022

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

scientific article

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation

scientific journal article

Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma.

scientific article

Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD).

scientific article

Stealth technology: how Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection.

scientific article published on October 2003

Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing

scientific article

Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials

scientific article

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

scientific article

The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas.

scientific article

Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.

scientific article published on November 1995

Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3.

scientific article published on 12 September 2011

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation

scientific article published on 01 November 2018

iTagPlot: an accurate computation and interactive drawing tool for tag density plot.

scientific article published on 19 March 2015

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