List of works - Dominique Leprince

A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP

scientific article

A New Mechanism of Oncogenic Activation: E26 Retroviral v-ets Oncogene Has Inverted the C-Terminal End of the Transcription Factor c-ets-1

scientific article published on 01 June 1993

A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.

scientific article published on 23 May 2013

A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.

scientific article

A residue of the ETS domain mutated in the v-ets oncogene is essential for the DNA-binding and transactivating properties of the ETS-1 and ETS-2 proteins.

scientific article

An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity

scientific article

Arginine 469 is a pivotal residue for the Hsc70-GlcNAc-binding property

scientific article published on 17 September 2010

Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1

scientific article

Chromosome arm 17p13.3: could HIC1 be the one ?

scientific article

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

scientific article published on September 1997

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair

scientific article published on 15 February 2013

Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics

scientific article published on 09 April 2013

Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor ⬇️

scientific article published on January 1, 1992

Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells

scientific article published on 14 June 2010

Evolution of the ets gene family.

scientific article published in January 1993

Evolutionary divergence in the broad complex, tramtrack and bric à brac/poxviruses and zinc finger domain from the candidate tumor suppressor gene hypermethylated in cancer.

scientific article published in May 1999

Function of ets genes is conserved between vertebrates and Drosophila.

scientific article published in September 1996

Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.

scientific article published in March 2011

Generation of two modified mouse alleles of the Hic1 tumor suppressor gene.

scientific article published in March 2011

HIC1 (Hypermethylated in Cancer 1) epigenetic silencing in tumors

scientific article published on 03 August 2008

HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).

scientific article published on 07 December 2016

HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis

scientific article published on May 2015

HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A

scientific article

HIC1 interacts with and modulates the activity of STAT3.

scientific article published on July 2013

Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1.

scientific article published in April 2004

Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53

scientific article (publication date: 2 February 2001)

Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1

scientific article (publication date: 13 May 2004)

Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1).

scientific article published on 22 November 2012

Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response

scientific article

Loss of Hypermethylated in Cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through β-2 adrenergic receptor (ADRB2) misregulation

scientific article published on 22 December 2011

Mapping of amplified c-myb oncogene, sister chromatid exchanges, and karyotypic analysis of the COLO 205 colon carcinoma cell line

article

Modifications épigénétiques et cancer

scientific article published on 01 April 2005

Molecular cloning and characterization of the chicken DNA locus related to the oncogene erbB of avian erythroblastosis virus

scientific article published on January 1982

Molecular dissection of the interaction between HIC1 and SIRT1

scientific article published on 09 April 2012

Multiple domains for the chicken cellular sequences homologous to the v-ets oncogene of the E26 retrovirus.

scientific article published on February 1987

Multiple domains participate in distance-independent LAZ3/BCL6-mediated transcriptional repression.

scientific article

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

scientific article

O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins

scientific article

Phylogeny of the p68c-ets-1 amino-terminal transactivating domain reveals some highly conserved structural features

scientific article published on July 1, 1992

Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation

scientific article published on 09 May 2016

RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex

retracted scientific journal article

Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B

scientific article

Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control

scientific article

Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).

scientific article published on 12 June 2009

The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins.

scientific article published in September 1995

The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.

scientific article

The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1 (Hypermethylated In Cancer 1).

scientific article published on 25 September 2013

The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved

scientific article

The chicken cellular progenitor of the v-ets oncogene, p68c-ets-1, is a nuclear DNA-binding protein not expressed in lymphoid cells of the spleen.

scientific article published on January 1990

The human DNA locus related to the oncogene myb of avian myeloblastosis virus (AMV): molecular cloning and structural characterization.

scientific article

The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif

scientific article

The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).

scientific article published on 19 December 2011

The transcription factor encyclopedia

scientific article (publication date: 2012)

The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated

scientific article published in October 2004

The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties

scientific article

The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1.

scientific article

The two functionally distinct amino termini of chicken c-ets-1 products arise from alternative promoter usage.

scientific article

[Preparation and characterization of antisera specific to various polypeptide domains corresponding to the v-ets oncogene of the avian leukemia virus E26]

scientific article published on 01 January 1986

c-ets-1 DNA binding to the PEA3 motif is differentially inhibited by all the mutations found in v-ets

scientific article published on January 1, 1992

p54c-ets-1 and p68c-ets-1, the two transcription factors encoded by the c-ets-1 locus, are differentially expressed during the development of the chick embryo.

scientific article published on September 1993

List of works by Dominique Leprince

A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP

A New Mechanism of Oncogenic Activation: E26 Retroviral v-ets Oncogene Has Inverted the C-Terminal End of the Transcription Factor c-ets-1

A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.

A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.

A residue of the ETS domain mutated in the v-ets oncogene is essential for the DNA-binding and transactivating properties of the ETS-1 and ETS-2 proteins.

An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity

Arginine 469 is a pivotal residue for the Hsc70-GlcNAc-binding property

Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1

Chromosome arm 17p13.3: could HIC1 be the one ?

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair

Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics

Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor ⬇️

Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells

Evolution of the ets gene family.

Evolutionary divergence in the broad complex, tramtrack and bric à brac/poxviruses and zinc finger domain from the candidate tumor suppressor gene hypermethylated in cancer.

Function of ets genes is conserved between vertebrates and Drosophila.

Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.

Generation of two modified mouse alleles of the Hic1 tumor suppressor gene.

HIC1 (Hypermethylated in Cancer 1) epigenetic silencing in tumors

HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).

HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis

HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A

HIC1 interacts with and modulates the activity of STAT3.

Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1.

Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53

Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1

Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1).

Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response

Loss of Hypermethylated in Cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through β-2 adrenergic receptor (ADRB2) misregulation

Mapping of amplified c-myb oncogene, sister chromatid exchanges, and karyotypic analysis of the COLO 205 colon carcinoma cell line

Modifications épigénétiques et cancer

Molecular cloning and characterization of the chicken DNA locus related to the oncogene erbB of avian erythroblastosis virus

Molecular dissection of the interaction between HIC1 and SIRT1

Multiple domains for the chicken cellular sequences homologous to the v-ets oncogene of the E26 retrovirus.

Multiple domains participate in distance-independent LAZ3/BCL6-mediated transcriptional repression.

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins

Phylogeny of the p68c-ets-1 amino-terminal transactivating domain reveals some highly conserved structural features

Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation

RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex

Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B

Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control

Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).

The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins.

The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.

The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1 (Hypermethylated In Cancer 1).

The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved

The chicken cellular progenitor of the v-ets oncogene, p68c-ets-1, is a nuclear DNA-binding protein not expressed in lymphoid cells of the spleen.

The human DNA locus related to the oncogene myb of avian myeloblastosis virus (AMV): molecular cloning and structural characterization.

The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif

The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).

The transcription factor encyclopedia

The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated

The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties

The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1.

The two functionally distinct amino termini of chicken c-ets-1 products arise from alternative promoter usage.

[Preparation and characterization of antisera specific to various polypeptide domains corresponding to the v-ets oncogene of the avian leukemia virus E26]

c-ets-1 DNA binding to the PEA3 motif is differentially inhibited by all the mutations found in v-ets

p54c-ets-1 and p68c-ets-1, the two transcription factors encoded by the c-ets-1 locus, are differentially expressed during the development of the chick embryo.