List of works - Michael A McDonough

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions

scientific article published on 5 July 2017

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

scientific article published on August 2013

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation

scientific article published on 28 October 2020

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor

scientific article

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold

scientific article

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

scientific article

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

scientific article published on 28 October 2019

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases

scientific article published on 20 February 2012

Binding of (5S)-penicilloic acid to penicillin binding protein 3

scientific article

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

scientific article published on 15 September 2020

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6

scientific article published on 30 May 2019

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

scientific article published on 03 December 2018

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal

article published in 2018

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

scientific article

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

scientific article

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase

article

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

scientific article

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

scientific article published on 21 April 2011

Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.

scientific article

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase

scientific article

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

scientific article

Crystallization and preliminary X-ray characterization of a thermostable pectate lyase from Thermotoga maritima

scientific article published on 22 March 2002

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

scientific article published in May 2017

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway

scientific article

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

scientific journal article

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

scientific article

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase

scientific article

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

scientific article

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

scientific article

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

scientific article

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

scientific article

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors ⬇️

scientific article published on 22 December 2017

Inhibition of 2-oxoglutarate dependent oxygenases

scientific article

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

scientific article

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

scientific article

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

scientific article

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

scientific article

MeLAD: an integrated resource for metalloenzyme-ligand associations

scientific article published on 01 February 2020

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

scientific article

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

scientific article published on 14 December 2016

New Structural Insights into the Inhibition of Serine Proteases by Cyclic Peptides from Bacteria ⬇️

scientific article published on October 1, 2003

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

scientific article

Oxygenase-Catalyzed Desymmetrization ofN,N-Dialkyl-piperidine-4-carboxylic Acids

scientific article (publication date: 6 October 2014)

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

scientific article

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

scientific article

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

scientific article

Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4.

scientific article

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

scientific article

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

scientific article

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

scientific article

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

scientific article

Selective inhibition of factor inhibiting hypoxia-inducible factor

scientific article published in June 2005

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

scientific article

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

scientific article

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis

scientific article

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

scientific article

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).

scientific article published on November 2007

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

scientific article

Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate.

scientific article published on 18 April 2017

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor

scientific article

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

scientific article

Structural insights into how 5-hydroxymethylation influences transcription factor binding

scientific article

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

scientific article

Structural studies on human 2-oxoglutarate dependent oxygenases

scientific article

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.

scientific article published on 23 February 2018

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity

scientific article

Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

scientific article

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

scientific article published on 9 December 2005

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases

scientific article

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

scientific article published on 03 December 2019

Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity

scientific article published on 31 August 2020

Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins

scientific article

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors

scientific article published on 01 March 2019

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

scientific article

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor

scientific article

The enzymes of β-lactam biosynthesis

scientific article

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids

scientific article published on 04 October 2005

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

scientific article published on 09 February 2021

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

scientific article

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

scientific article

YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase.

scientific article published on 9 March 2018

List of works by Michael A McDonough

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases

Binding of (5S)-penicilloic acid to penicillin binding protein 3

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Crystallization and preliminary X-ray characterization of a thermostable pectate lyase from Thermotoga maritima

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors ⬇️

Inhibition of 2-oxoglutarate dependent oxygenases

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

MeLAD: an integrated resource for metalloenzyme-ligand associations

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

New Structural Insights into the Inhibition of Serine Proteases by Cyclic Peptides from Bacteria ⬇️

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

Oxygenase-Catalyzed Desymmetrization ofN,N-Dialkyl-piperidine-4-carboxylic Acids

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4.

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

Selective inhibition of factor inhibiting hypoxia-inducible factor

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate.

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

Structural insights into how 5-hydroxymethylation influences transcription factor binding

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

Structural studies on human 2-oxoglutarate dependent oxygenases

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity

Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity

Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteins

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor

The enzymes of β-lactam biosynthesis

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase